Curariform Antagonists Bind in Different Orientations to Acetylcholine-binding Protein*
Gao F, Bern N, Little A, Wang HL, Hansen SB, Talley TT, Taylor P, Sine SM. Curariform Antagonists Bind in Different Orientations to Acetylcholine-binding Protein*. Journal Of Biological Chemistry 2003, 278: 23020-23026. PMID: 12682067, PMCID: PMC3191914, DOI: 10.1074/jbc.m301151200.Peer-Reviewed Original ResearchConceptsAcetylcholine-binding proteinDocking orientationTrp-53Site residuesSubunit interfaceLigand bindingProtein flexibilityAChBPNicotinic acetylcholine receptorsSide chainsTyr-89Binding sitesMutagenesisReceptor binding sitesAcetylcholine receptorsProteinSimilar ligandsDynamic structureBindingStructure-activity relationshipsMolecular dynamics simulationsEquivalent nitrogenComputational methodsStructural levelDistinct orientations