2012
Sleep Problems in Children with Sickle Cell Disease
Khatwa U, Bazzy-Asaad A, Kothare S. Sleep Problems in Children with Sickle Cell Disease. Respiratory Medicine 2012, 323-336. DOI: 10.1007/978-1-60761-725-9_24.Peer-Reviewed Original ResearchSleep-disordered breathingSickle cell diseaseSleep problemsCell diseaseUpper airway obstructionGeneral pediatric populationVaso-occlusive crisisCommon sleep problemsNocturnal hypoxemiaAirway obstructionPulmonary hypertensionAdenotonsillar hypertrophySecondary hyperplasiaSplenic infarctionClinical presentationPediatric populationLymphoid tissuePrevalent hemoglobinopathyOxyhemoglobin saturationTreatment strategiesExtramedullary hematopoiesisPulse oximetryHypoxemiaChildrenDisease
2008
Sleep-Disordered Breathing in Children With Metabolic Syndrome: The Role of Leptin and Sympathetic Nervous System Activity and the Effect of Continuous Positive Airway Pressure
Nakra N, Bhargava S, Dzuira J, Caprio S, Bazzy-Asaad A. Sleep-Disordered Breathing in Children With Metabolic Syndrome: The Role of Leptin and Sympathetic Nervous System Activity and the Effect of Continuous Positive Airway Pressure. Pediatrics 2008, 122: e634-e642. PMID: 18762497, PMCID: PMC5117807, DOI: 10.1542/peds.2008-0154.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressureSleep-disordered breathingSympathetic nervous system activityPositive airway pressureNervous system activityWhole-body insulin sensitivityMetabolic syndromeAirway pressureLeptin levelsInsulin sensitivitySystem activityExact testContinuous positive airway pressure (CPAP) treatmentPositive airway pressure treatmentC-reactive protein levelsOral glucose tolerance testGlucose tolerance testRole of leptinBMI z-scoreFisher's exact testOvernight polysomnographyBreathing groupMetabolic derangementsInsulin resistanceSleep Questionnaire