Gentamicin nephrotoxicity in extrahepatic cholestasis: Modulation by dietary calcium
Vakil N, Abu‐Alfa A, Mujais S. Gentamicin nephrotoxicity in extrahepatic cholestasis: Modulation by dietary calcium. Hepatology 1989, 9: 519-524. PMID: 2925154, DOI: 10.1002/hep.1840090402.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalciumCholestasis, ExtrahepaticGentamicinsKidney DiseasesMaleRatsRats, Inbred StrainsConceptsDietary calcium supplementationGentamicin nephrotoxicityCalcium supplementationLigation animalsExtrahepatic cholestasisCommon bile duct ligation groupCommon bile duct ligation ratsBile duct ligation groupCommon bile duct obstructionBile duct ligation ratsMale Sprague-Dawley ratsUrinary calcium excretionHigh calcium dietBile duct obstructionBile duct ligationSprague-Dawley ratsCourse of therapyExperimental extrahepatic cholestasisSevere azotemiaCalcium excretionConcurrent administrationDuct obstructionGentamicin administrationSham ratsDietary calcium