2013
Neuroprotection against neuroblastoma cell death induced by depletion of mitochondrial glutathione
Dukhande VV, Kawikova I, Bothwell AL, Lai JC. Neuroprotection against neuroblastoma cell death induced by depletion of mitochondrial glutathione. Apoptosis 2013, 18: 702-712. PMID: 23494481, PMCID: PMC3645366, DOI: 10.1007/s10495-013-0836-4.Peer-Reviewed Original ResearchMeSH KeywordsApoptosisAzolesBcl-2-Associated X ProteinButhionine SulfoximineCell Line, TumorCell SurvivalCoculture TechniquesCytochromes cCytosolEthacrynic AcidGlioblastomaGlutathioneHumansIsoindolesMitochondriaNeuroblastomaNeuronsOrganoselenium CompoundsProto-Oncogene Proteins c-bcl-2Reactive Oxygen SpeciesConceptsSK-N-SH cellsMitochondrial glutathioneCell deathNeuroblastoma cell deathMitochondrial dysfunctionCellular reactive oxygen speciesMitochondrial glutathione poolPrevention of apoptosisMitochondrial glutathione depletionNeurodegenerative disordersOxidative stressGlutathione depletionReactive oxygen speciesGlutathione poolDistinct inhibitorsApoptotic deathGlutathione metabolismEthacrynic acidROS productionOxygen speciesBCL2 overexpressionGSH depletionApoptosisL-buthionineCells
2010
An Implantable Vascularized Protein Gel Construct That Supports Human Fetal Hepatoblast Survival and Infection by Hepatitis C Virus in Mice
Harding MJ, Lepus CM, Gibson TF, Shepherd BR, Gerber SA, Graham M, Paturzo FX, Rahner C, Madri JA, Bothwell AL, Lindenbach BD, Pober JS. An Implantable Vascularized Protein Gel Construct That Supports Human Fetal Hepatoblast Survival and Infection by Hepatitis C Virus in Mice. PLOS ONE 2010, 5: e9987. PMID: 20376322, PMCID: PMC2848675, DOI: 10.1371/journal.pone.0009987.Peer-Reviewed Original ResearchConceptsHepatitis C virusHuman fetal hepatoblastsSmall animal modelsC virusAnimal modelsAccessible small animal modelsHuh-7.5 hepatoma cellsRobust small animal modelHuman hepatocyte engraftmentHuman albumin levelsBcl-2-transduced human umbilical vein endothelial cellsHuman umbilical vein endothelial cellsHepatocyte growth factorUmbilical vein endothelial cellsHCV infectionVein endothelial cellsAlbumin levelsHepatocyte engraftmentBeige miceImmunodeficient miceHistological appearanceImmunoelectron microscopic analysisMRNA expressionViral adsorptionHepatic epithelial cells
2006
Pivotal roles of CD8+ T cells restricted by MHC class I–like molecules in autoimmune diseases
Das G, Das J, Eynott P, Zhang Y, Bothwell AL, Van Kaer L, Shi Y. Pivotal roles of CD8+ T cells restricted by MHC class I–like molecules in autoimmune diseases. Journal Of Experimental Medicine 2006, 203: 2603-2611. PMID: 17088432, PMCID: PMC2118151, DOI: 10.1084/jem.20060936.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoimmune DiseasesBeta 2-MicroglobulinCD8-Positive T-LymphocytesCell SurvivalFemaleH-2 AntigensHistocompatibility Antigen H-2DHistocompatibility Antigens Class IIInflammatory Bowel DiseasesIslets of LangerhansLymphoproliferative DisordersMaleMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicNuclear ProteinsTrans-ActivatorsConceptsInnate-like lymphocytesInflammatory bowel diseaseMHC class IT cellsAutoimmune diseasesClass IMajor histocompatibility complex class IaLike moleculesClass II moleculesAdoptive transferBowel diseaseAutoimmune disordersLymphoproliferative syndromeImmunoregulatory functionsAdaptive immunityCD8Class IaDiseaseMiceInsulitisAutoimmunityPivotal roleCellsLymphocytesSyndrome