2014
A Humanized Mouse Model of Autoimmune Insulitis
Milam A, Maher SE, Gibson JA, Lebastchi J, Wen L, Ruddle NH, Herold KC, Bothwell AL. A Humanized Mouse Model of Autoimmune Insulitis. Diabetes 2014, 63: 1712-1724. PMID: 24478396, PMCID: PMC3994947, DOI: 10.2337/db13-1141.Peer-Reviewed Original ResearchConceptsT cellsDiabetic donorsInsulin stainingMouse modelAntigen-pulsed cellsAutoantigen-derived peptidesNOD mouse modelHumanized mouse modelType 1 diabetesPancreatic β-cellsT cell linesHuman T cellsIslet infiltrationAutoimmune diabetesNOD-SCIDAutoimmune insulitisHuman diabetesDestructive infiltrationMouse isletsMechanism of inductionΒ-cellsDiabetesDiabetes researchDisease modelsInsulitis
2008
Promotion of β-Cell Differentiation in Pancreatic Precursor Cells by Adult Islet Cells
Chen W, Begum S, Opare-Addo L, Garyu J, Gibson TF, Bothwell AL, Papaioannou VE, Herold KC. Promotion of β-Cell Differentiation in Pancreatic Precursor Cells by Adult Islet Cells. Endocrinology 2008, 150: 570-579. PMID: 18845629, PMCID: PMC2646532, DOI: 10.1210/en.2008-1009.Peer-Reviewed Original ResearchConceptsAdult islet cellsAnlage cellsBeta-cell differentiationMusculoaponeurotic fibrosarcoma oncogene homologGlucose transporter 2Mature islet cellsΒ-cell differentiationPrecursor cellsCell-cell contactProduction of proinsulinPancreatic duodenal homeobox-1Pancreatic precursor cellsTranscription factorsDuodenal homeobox 1Islet cellsBeta-cell transcription factorsStromal cell-derived factor-1Differentiation processCell-derived factor-1Beta-cell precursorsMature cellsHomeobox 1Conditions differentiationOncogene homologFactor 1