2014
Interplay between DNA repair and inflammation, and the link to cancer
Kidane D, Chae WJ, Czochor J, Eckert KA, Glazer PM, Bothwell AL, Sweasy JB. Interplay between DNA repair and inflammation, and the link to cancer. Critical Reviews In Biochemistry And Molecular Biology 2014, 49: 116-139. PMID: 24410153, PMCID: PMC4300235, DOI: 10.3109/10409238.2013.875514.Peer-Reviewed Original Research
2013
Neuroprotection against neuroblastoma cell death induced by depletion of mitochondrial glutathione
Dukhande VV, Kawikova I, Bothwell AL, Lai JC. Neuroprotection against neuroblastoma cell death induced by depletion of mitochondrial glutathione. Apoptosis 2013, 18: 702-712. PMID: 23494481, PMCID: PMC3645366, DOI: 10.1007/s10495-013-0836-4.Peer-Reviewed Original ResearchMeSH KeywordsApoptosisAzolesBcl-2-Associated X ProteinButhionine SulfoximineCell Line, TumorCell SurvivalCoculture TechniquesCytochromes cCytosolEthacrynic AcidGlioblastomaGlutathioneHumansIsoindolesMitochondriaNeuroblastomaNeuronsOrganoselenium CompoundsProto-Oncogene Proteins c-bcl-2Reactive Oxygen SpeciesConceptsSK-N-SH cellsMitochondrial glutathioneCell deathNeuroblastoma cell deathMitochondrial dysfunctionCellular reactive oxygen speciesMitochondrial glutathione poolPrevention of apoptosisMitochondrial glutathione depletionNeurodegenerative disordersOxidative stressGlutathione depletionReactive oxygen speciesGlutathione poolDistinct inhibitorsApoptotic deathGlutathione metabolismEthacrynic acidROS productionOxygen speciesBCL2 overexpressionGSH depletionApoptosisL-buthionineCells