2012
The Nuclear Receptor PPARs as Important Regulators of T-Cell Functions and Autoimmune Diseases
Choi JM, Bothwell AL. The Nuclear Receptor PPARs as Important Regulators of T-Cell Functions and Autoimmune Diseases. Molecules And Cells 2012, 33: 217-222. PMID: 22382683, PMCID: PMC3887706, DOI: 10.1007/s10059-012-2297-y.Peer-Reviewed Original ResearchConceptsPeroxisome proliferator-activated receptorIndependent regulatory mechanismsImportant regulatory roleNuclear receptor proteinsT helper cell differentiationTranscription factorsCellular differentiationNuclear receptor peroxisome proliferator-activated receptorGene expressionRegulatory mechanismsDiverse rolesHelper cell differentiationT cell survivalPPARβ/δCell differentiationRegulatory roleImportant regulatorReceptor proteinNuclear receptorsT cell activationProliferator-activated receptorAutoimmune diseasesLigand treatmentProteinSynthetic ligands
2007
Regulatory Transplantation Tolerance and “Stemness”: Evidence That Foxp3 May Play a Regulatory Role in SOCS-3 Gene Transcription
Muthukumarana P, Chae WJ, Maher S, Rosengard BR, Bothwell AL, Metcalfe SM. Regulatory Transplantation Tolerance and “Stemness”: Evidence That Foxp3 May Play a Regulatory Role in SOCS-3 Gene Transcription. Transplantation 2007, 84: s6-s11. PMID: 17632414, DOI: 10.1097/01.tp.0000269116.06510.db.Peer-Reviewed Original ResearchConceptsExpression of Foxp3Wt-Foxp3Regulatory transplantation toleranceSOCS-3Immune effector cellsStem cell-related factorsHuman T cell lineCell-related factorsT cell linesJurkat human T cell lineSOCS-3 transcriptsLIF transcriptionSuppressor of cytokineTransplantation toleranceEffector cellsT lymphocytesFoxp3Inhibitory factorKey mediatorT cell signal transductionAxotrophinTregsFurther evidenceTranscriptional activityRegulatory role