2019
Dickkopf1: An immunomodulatory ligand and Wnt antagonist in pathological inflammation
Chae WJ, Bothwell ALM. Dickkopf1: An immunomodulatory ligand and Wnt antagonist in pathological inflammation. Differentiation 2019, 108: 33-39. PMID: 31221431, PMCID: PMC6982462, DOI: 10.1016/j.diff.2019.05.003.Peer-Reviewed Original ResearchConceptsCell proliferationPro-inflammatory ligandsRole of DKK1Pro-inflammatory roleRepair processPoor disease outcomeOrgan homeostasisTransduction pathwaysCanonical WntCell differentiationTissue repair processMulticellular interactionsOrgan injuryCell typesInflammatory diseasesTissue injuryDisease outcomeImmune responseWntBone diseaseWnt antagonistsPathological inflammationMusculoskeletal diseasesExpression levelsDickkopf1
2018
Therapeutic Potential of Gene-Modified Regulatory T Cells: From Bench to Bedside
Chae WJ, Bothwell ALM. Therapeutic Potential of Gene-Modified Regulatory T Cells: From Bench to Bedside. Frontiers In Immunology 2018, 9: 303. PMID: 29503652, PMCID: PMC5820299, DOI: 10.3389/fimmu.2018.00303.Peer-Reviewed Original ResearchConceptsRegulatory T cellsInflammatory diseasesT cellsImmune responseEffective antitumor immune responseTherapeutic potentialT cell receptor specificityDysfunction of TregsField of TregsAberrant immune responseAdaptive immune cellsAntitumor immune responseInherent genetic defectsRecognition of antigenTreg functionChronic inflammationImmune cellsTregsImmune reactionsRecipients resultsTherapeutic approachesBasic research findingsOrgan donorsSuppressive functionImmune system
2016
Snapshots of CD4 + T cell plasticity in the pathogenesis of allergic asthma
Chae WJ, Bothwell AL. Snapshots of CD4 + T cell plasticity in the pathogenesis of allergic asthma. Journal Of Thoracic Disease 2016, 8: e1010-e1012. PMID: 27747048, PMCID: PMC5059289, DOI: 10.21037/jtd.2016.08.19.Peer-Reviewed Original ResearchThymic stromal lymphopoietinHouse dust miteAllergic asthmaDendritic cellsType 2 inflammatory diseasesT helper type 2 cellsNaïve CD4 T cellsCD4 T cellsHumoral immune responseTh2 effector cellsT cell plasticityType 2 cellsLung epithelial cellsIL-25Lung eosinophiliaIL-33Effector cellsEnvironmental allergensTh2 cytokinesDust miteInflammatory diseasesT cellsImmune responseB cellsEpithelial cells
2015
dNP2 is a blood–brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis
Lim S, Kim WJ, Kim YH, Lee S, Koo JH, Lee JA, Yoon H, Kim DH, Park HJ, Kim HM, Lee HG, Yun Kim J, Lee JU, Hun Shin J, Kyun Kim L, Doh J, Kim H, Lee SK, Bothwell AL, Suh M, Choi JM. dNP2 is a blood–brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis. Nature Communications 2015, 6: 8244. PMID: 26372309, PMCID: PMC4579786, DOI: 10.1038/ncomms9244.Peer-Reviewed Original ResearchConceptsExperimental autoimmune encephalomyelitisMultiple sclerosisT cellsAutoimmune encephalomyelitisCytotoxic T-lymphocyte antigen-4T-lymphocyte antigen-4T helper 17 (Th17) cellsCNS inflammatory diseasesTherapeutic mouse modelsEffector T cellsHelper 17 cellsT helper 1Blood-brain barrierCentral nervous systemHuman T cellsHelper 1Antigen-4Inflammatory diseasesMouse modelNervous systemCurrent drugsResident cellsBrain tissueEffective agentCell-permeable peptideSpontaneous Intestinal Tumorigenesis in Apc/Min+ Mice Requires Altered T Cell Development with IL‐17A
Chae WJ, Bothwell AL. Spontaneous Intestinal Tumorigenesis in Apc/Min+ Mice Requires Altered T Cell Development with IL‐17A. Journal Of Immunology Research 2015, 2015: 860106. PMID: 26146642, PMCID: PMC4469837, DOI: 10.1155/2015/860106.Peer-Reviewed Original ResearchConceptsApc miceGATA-3 expressionIntestinal tumorigenesisFamilial adenomatous polyposisT cell developmentAdoptive transferIL-17AT cellsFunctional regulatory T cellsNaïve CD4 T cellsFrequency of Foxp3Regulatory T cellsAbility of TregsGene mutationsCD4 T cellsSpontaneous intestinal tumorigenesisWild-type TregsHuman familial adenomatous polyposisApc mouse modelAPC gene mutationsCell developmentAltered T cell developmentInflammatory diseasesTregsLamina propria