2015
Spontaneous Intestinal Tumorigenesis in Apc/Min+ Mice Requires Altered T Cell Development with IL-17A
Chae WJ, Bothwell AL. Spontaneous Intestinal Tumorigenesis in Apc/Min+ Mice Requires Altered T Cell Development with IL-17A. Journal Of Immunology Research 2015, 2015: 860106. PMID: 26146642, PMCID: PMC4469837, DOI: 10.1155/2015/860106.Peer-Reviewed Original ResearchConceptsApc miceGATA-3 expressionIntestinal tumorigenesisFamilial adenomatous polyposisT cell developmentAdoptive transferIL-17AT cellsFunctional regulatory T cellsNaïve CD4 T cellsFrequency of Foxp3Regulatory T cellsAbility of TregsGene mutationsCD4 T cellsSpontaneous intestinal tumorigenesisWild-type TregsHuman familial adenomatous polyposisApc mouse modelAPC gene mutationsCell developmentAltered T cell developmentInflammatory diseasesTregsLamina propria
2011
IL-17F deficiency inhibits small intestinal tumorigenesis in ApcMin/+ mice
Chae WJ, Bothwell AL. IL-17F deficiency inhibits small intestinal tumorigenesis in ApcMin/+ mice. Biochemical And Biophysical Research Communications 2011, 414: 31-36. PMID: 21939640, DOI: 10.1016/j.bbrc.2011.09.016.Peer-Reviewed Original ResearchConceptsIL-17FSpontaneous intestinal tumorigenesisIntestinal tumorigenesisLamina propriaCD4 T cellsImmune cell infiltrationCOX-2 expressionSmall intestinal tumorigenesisIL-17IL-17AIL-17A.IL-17F.Thymic atrophyIL-1βCell infiltrationT cellsGut homeostasisSmall intestineMiceSignificant decreaseC expressionTumorigenesisPropriaIntestineAblation
2010
Ablation of IL-17A abrogates progression of spontaneous intestinal tumorigenesis
Chae WJ, Gibson TF, Zelterman D, Hao L, Henegariu O, Bothwell AL. Ablation of IL-17A abrogates progression of spontaneous intestinal tumorigenesis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 5540-5544. PMID: 20212110, PMCID: PMC2851824, DOI: 10.1073/pnas.0912675107.Peer-Reviewed Original ResearchConceptsCD4 T cellsSpontaneous intestinal tumorigenesisIL-17AT cellsIntestinal tumorigenesisRegulatory T cell-mediated suppressionEffector CD4 T cellsT cell-mediated suppressionEndogenous IL-17ACell-mediated suppressionInfiltration of lymphocytesIntestinal epithelial cellsHyperproliferative potentialImmunological abnormalitiesAdoptive transferIL-10Proinflammatory mediatorsThymic atrophyInflammatory cytokinesImmunodeficient miceIntestinal architectureHeterozygote mutationsAltered functionMiceTumor development