2004
Bcl-2 Transduction Protects Human Endothelial Cell Synthetic Microvessel Grafts from Allogeneic T Cells In Vivo
Zheng L, Gibson TF, Schechner JS, Pober JS, Bothwell AL. Bcl-2 Transduction Protects Human Endothelial Cell Synthetic Microvessel Grafts from Allogeneic T Cells In Vivo. The Journal Of Immunology 2004, 173: 3020-3026. PMID: 15322161, DOI: 10.4049/jimmunol.173.5.3020.Peer-Reviewed Original ResearchConceptsEndothelial cellsAllogeneic T cellsT cell responsesHuman immune responseT cell interactionsVascular endothelial cellsHuman T lymphocytesGraft infiltrationAdoptive transferAllograft rejectionImmune surveillanceT cellsT lymphocytesImmune responseImmunological functionsMurine modelAnimal modelsVivo findingsCell responsesMicrovascular bedBcl-2 proteinPathological processesGraftCell interactionsCells
2003
Engraftment of a vascularized human skin equivalent
Schechner JS, Crane SK, Wang F, Szeglin AM, Tellides G, Lorber MI, Bothwell AL, Pober JS. Engraftment of a vascularized human skin equivalent. The FASEB Journal 2003, 17: 2250-2256. PMID: 14656987, DOI: 10.1096/fj.03-0257com.Peer-Reviewed Original ResearchConceptsHuman umbilical vein endothelial cellsHuman skin equivalentsAcellular dermis graftsSkin equivalentsBcl-2-transduced human umbilical vein endothelial cellsUmbilical vein endothelial cellsEndothelial cell transplantationVein endothelial cellsCultured human keratinocytesCell transplantationSurvival gene bcl-2Orthotopic implantationSuccessful transplantationDermis graftImmunodeficient miceClinical utilityGraft vascularizationImpaired angiogenesisGene Bcl-2Bcl-2-transduced cellsAcellular dermisEndothelial cellsClinical performanceGraftBcl-2