Promotion of β-Cell Differentiation in Pancreatic Precursor Cells by Adult Islet Cells
Chen W, Begum S, Opare-Addo L, Garyu J, Gibson TF, Bothwell AL, Papaioannou VE, Herold KC. Promotion of β-Cell Differentiation in Pancreatic Precursor Cells by Adult Islet Cells. Endocrinology 2008, 150: 570-579. PMID: 18845629, PMCID: PMC2646532, DOI: 10.1210/en.2008-1009.Peer-Reviewed Original ResearchConceptsAdult islet cellsAnlage cellsBeta-cell differentiationMusculoaponeurotic fibrosarcoma oncogene homologGlucose transporter 2Mature islet cellsΒ-cell differentiationPrecursor cellsCell-cell contactProduction of proinsulinPancreatic duodenal homeobox-1Pancreatic precursor cellsTranscription factorsDuodenal homeobox 1Islet cellsBeta-cell transcription factorsStromal cell-derived factor-1Differentiation processCell-derived factor-1Beta-cell precursorsMature cellsHomeobox 1Conditions differentiationOncogene homologFactor 1