2014
Mutation of POLB Causes Lupus in Mice
Senejani AG, Liu Y, Kidane D, Maher SE, Zeiss CJ, Park HJ, Kashgarian M, McNiff JM, Zelterman D, Bothwell AL, Sweasy JB. Mutation of POLB Causes Lupus in Mice. Cell Reports 2014, 6: 1-8. PMID: 24388753, PMCID: PMC3916967, DOI: 10.1016/j.celrep.2013.12.017.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusLupus-like diseaseLupus erythematosusAutoimmune pathologyMouse modelGenome-wide association studiesPol β activityDecreased expressionMutant miceUnderlying causeMicePrevious genome-wide association studyΒ activityDNA polymerase activityReplication studyExcision repair pathwayImmune diversitySomatic hypermutationBase excision repair pathwayAssociation studiesErythematosusLupusPolymerase activityExpressionKey enzyme
2003
Human trophoblast noncoding RNA suppresses CIITA promoter III activity in murine B-lymphocytes
Geirsson A, Lynch RJ, Paliwal I, Bothwell AL, Hammond GL. Human trophoblast noncoding RNA suppresses CIITA promoter III activity in murine B-lymphocytes. Biochemical And Biophysical Research Communications 2003, 301: 718-724. PMID: 12565840, DOI: 10.1016/s0006-291x(03)00028-7.Peer-Reviewed Original ResearchConceptsClass II expressionCIITA expressionPromoter IIIClassical MHC antigensMHC class IICIITA promoter IIIAllograft toleranceMHC antigensMurine B lymphocytesFunctional assessmentB lymphocytesClass III-AkIII activityPromoter-reporter constructsTrophoblastCH27BlotTransient transfectionExpressionNorthern blotNegative trans-acting factorsNoncoding RNAsSuppressionTrans-acting factors