The RpoS Gatekeeper in Borrelia burgdorferi: An Invariant Regulatory Scheme That Promotes Spirochete Persistence in Reservoir Hosts and Niche Diversity
Caimano MJ, Groshong AM, Belperron A, Mao J, Hawley KL, Luthra A, Graham DE, Earnhart CG, Marconi RT, Bockenstedt LK, Blevins JS, Radolf JD. The RpoS Gatekeeper in Borrelia burgdorferi: An Invariant Regulatory Scheme That Promotes Spirochete Persistence in Reservoir Hosts and Niche Diversity. Frontiers In Microbiology 2019, 10: 1923. PMID: 31507550, PMCID: PMC6719511, DOI: 10.3389/fmicb.2019.01923.Peer-Reviewed Original ResearchΣ factorsPhase genesDual-color reporter systemParalogous gene familiesRpoS-regulated genesAlternative σ factorsOligopeptide-binding proteinComplex regulatory pathwaysNymphal blood mealsVariable surface lipoproteinsEnzootic cycleSyntenic genesRpoS regulonOrthologous genesNiche diversityGene familyPersistence genesMammalian phaseTranscribes genesSpirochete persistenceRpoS pathwayMammalian infectionTransposon mutantsMaximal fitnessRegulatory pathways