2006
A multicenter, randomized, dose-finding study of gamma intracoronary radiation therapy to inhibit recurrent restenosis after stenting.
Price MJ, Moses JW, Leon MB, Mehran R, Negoita M, Lansky A, Collins M, Giap H, Lin R, Jani S, Steuterman S, Balter S, Dalton J, Lipsztein R, Tripuraneni P, Teirstein PS. A multicenter, randomized, dose-finding study of gamma intracoronary radiation therapy to inhibit recurrent restenosis after stenting. Journal Of Invasive Cardiology 2006, 18: 169-73. PMID: 16732060.Peer-Reviewed Original ResearchConceptsIntracoronary radiation therapyStent restenosisRadiation therapyLesion late lossTarget lesion revascularizationHigh-dose groupDose-finding studySignificant clinical problemBare metal stentsRadiation dose prescriptionHigh radiation doseBinary restenosisLesion revascularizationRecurrent restenosisVessel revascularizationAdverse eventsCoronary interventionRecurrent stenosisComposite endpointRandomized studyDose groupClinical eventsMyocardial infarctionRadiation failureGy group
2003
Comparison of the angiographic outcomes after beta versus gamma vascular brachytherapy for treatment of in-stent restenosis
Shirai K, Lansky AJ, Mintz GS, Costantini CO, Fahy M, Mehran R, Dangas G, Moses JW, Stone GW, Waksman R, Leon MB. Comparison of the angiographic outcomes after beta versus gamma vascular brachytherapy for treatment of in-stent restenosis. The American Journal Of Cardiology 2003, 92: 1409-1413. PMID: 14675575, DOI: 10.1016/j.amjcard.2003.08.047.Peer-Reviewed Original ResearchConceptsMinimum lumen diameterVascular brachytherapyLesion lengthSegment restenosisAngiographic outcomesStent restenosisFinal minimum lumen diameterRandomized clinical trialsIndependent angiographic predictorsAngiographic restenosisPlacebo groupAngiographic predictorsAngiographic resultsMultivariable analysisNative coronariesVessel sizeClinical trialsLesion complexityVBT groupRestenosisLumen diameterSimilar reductionPlaceboGreater reductionLesionsUsefulness of the angiographic pattern of in-stent restenosis in predicting the success of gamma vascular brachytherapy
Costantini CO, Lansky AJ, Mintz GS, Shirai K, Dangas G, Mehran R, Stone GW, Leon MB. Usefulness of the angiographic pattern of in-stent restenosis in predicting the success of gamma vascular brachytherapy. The American Journal Of Cardiology 2003, 92: 1214-1217. PMID: 14609602, DOI: 10.1016/j.amjcard.2003.07.036.Peer-Reviewed Original ResearchConceptsStent restenosisAngiographic patternsVascular brachytherapyMajor adverse cardiac event ratesAdverse cardiac event ratesBinary angiographic restenosis rateAngiographic restenosis rateCardiac event rateStent restenosis patternsRestenosis patternLesion revascularizationPrognostic roleRestenosis rateTotal occlusionClinical trialsProliferative patternEvent ratesRestenosisPooled data setBrachytherapyRevascularizationPatientsAngiogramsBaselineTrialsLong-term follow-up of patients after gamma intracoronary brachytherapy failure (from GAMMA-I, GAMMA-II, and SCRIPPS-III)
Limpijankit T, Mehran R, Mintz GS, Dangas G, Lansky AJ, Kao J, Ashby DT, Moussa I, Stone GW, Moses JW, Leon MB, Teirstein PS. Long-term follow-up of patients after gamma intracoronary brachytherapy failure (from GAMMA-I, GAMMA-II, and SCRIPPS-III). The American Journal Of Cardiology 2003, 92: 315-318. PMID: 12888143, DOI: 10.1016/s0002-9149(03)00636-2.Peer-Reviewed Original ResearchConceptsAdverse eventsCoronary Artery Bypass GraftingTotal adverse eventsArtery Bypass GraftingCoronary artery bypassFirst-line therapyPercutaneous coronary interventionLong-term outcomesBrachytherapy failureArtery bypassBypass GraftingVessel revascularizationCoronary interventionIndependent predictorsMyocardial infarctionRadiation failureStent restenosisLate thrombosisPatientsTherapyBrachytherapyRevascularizationInfarctionThrombosisFailureIntravascular brachytherapy for native coronary ostial in-stent restenotic lesions
Costantini CO, Lansky AJ, Mintz GS, Shirai K, Dangas G, Mehran R, Fahy M, Slack S, Coral M, Teirstein PS, Waksman R, Stone G, Moses J, Leon MB. Intravascular brachytherapy for native coronary ostial in-stent restenotic lesions. Journal Of The American College Of Cardiology 2003, 41: 1725-1731. PMID: 12767655, DOI: 10.1016/s0735-1097(03)00298-5.Peer-Reviewed Original ResearchConceptsAorto-ostial lesionsVascular brachytherapyRecurrence rateOstial ISRRestenosis rateStent restenosisBaseline lesion lengthStent restenotic lesionsHigh recurrence rateBinary restenosisPercutaneous reinterventionPlacebo patientsISR lesionsRestenotic lesionsQuantitative angiographyBeta patientsPatientsPooled databaseConventional treatmentRestenosisPlaceboLesionsLesion lengthBrachytherapySimilar reduction
2002
Late Vascular Response to Repeat Stenting for In-Stent Restenosis With and Without Radiation
Morino Y, Limpijankit T, Honda Y, Lansky AJ, Waksman R, Bonneau HN, Yock PG, Mintz GS, Fitzgerald PJ. Late Vascular Response to Repeat Stenting for In-Stent Restenosis With and Without Radiation. Circulation 2002, 105: 2465-2468. PMID: 12034650, DOI: 10.1161/01.cir.0000018949.39445.40.Peer-Reviewed Original ResearchMeSH KeywordsBlood Vessel Prosthesis ImplantationBrachytherapyCohort StudiesCoronary RestenosisDisease ProgressionDouble-Blind MethodFollow-Up StudiesGamma RaysHumansIridium RadioisotopesPlatelet Aggregation InhibitorsRandomized Controlled Trials as TopicRecurrenceReoperationStentsTiclopidineTimeTreatment OutcomeUltrasonography, InterventionalVascular PatencyConceptsLumen volume indexISR lesionsPlacebo patientsLate vascular responseAcute angiographic resultsIntravascular ultrasound analysisIn-Stent RestenosisPlacebo groupAngiographic resultsVascular responsesAdditional lumenNeointimal proliferationStent restenosisIrradiated groupPatientsStent overlapLesionsVolume indexUltrasound analysisSafety of radiationLong-term advantagesStent strutsSignificant decreaseStentingRestenosis
2001
Intravascular Radiation Therapy after Balloon Angioplasty of Narrowed Femoropopliteal Arteries to Prevent Restenosis: Results of the PARIS Feasibility Clinical Trial
Waksman R, Laird J, Jurkovitz C, Lansky A, Gerrits F, Kosinski A, Murrah N, Weintraub W, Investigators F. Intravascular Radiation Therapy after Balloon Angioplasty of Narrowed Femoropopliteal Arteries to Prevent Restenosis: Results of the PARIS Feasibility Clinical Trial. Journal Of Vascular And Interventional Radiology 2001, 12: 915-921. PMID: 11487671, DOI: 10.1016/s1051-0443(07)61569-3.Peer-Reviewed Original ResearchConceptsPercutaneous transluminal angioplastyAnkle-brachial indexRadiation therapySFA lesionsRestenosis rateBalloon angioplastyAngiographic binary restenosis rateMean reference vessel diameterSuccessful percutaneous transluminal angioplastySuperficial femoral artery lesionsClinical restenosis rateFeasibility clinical trialBinary restenosis rateClinical adverse eventsReference vessel diameterFemoral artery lesionsMean lesion lengthRate gamma radiationIntravascular radiation therapyMicroSelectron-HDR afterloaderGamma radiation therapyRutherford scoreAdverse eventsArtery lesionsClinical improvementIntracoronary radiation with gamma wire inhibits recurrent in-stent restenosis
Waksman R, Bhargava B, Chan R, Sherman W, Pisch J, Mintz G, Lansky A, Ahmed J, Ricci N, Liprie S. Intracoronary radiation with gamma wire inhibits recurrent in-stent restenosis. Cardiovascular Revascularization Medicine 2001, 2: 63-68. PMID: 11340009, DOI: 10.1016/s1522-1865(00)00086-x.Peer-Reviewed Original ResearchConceptsIntracoronary gamma radiationTarget lesion revascularizationStent restenosisMyocardial infractionBaseline lesion lengthUnderwent bypass surgeryBinary restenosis rateEvent-free survivalNeointimal tissue proliferationInitial clinical trialsStent restenosis resultsSource wireLesion revascularizationRepeat PTCAAngiographic restenosisPrimary endpointRepeat revascularizationSecondary endpointsBypass surgeryRestenosis rateIntracoronary radiationProcedural successTherapeutic challengeClinical trialsNeointimal hyperplasiaLocalized Intracoronary Gamma-Radiation Therapy to Inhibit the Recurrence of Restenosis after Stenting
Leon M, Teirstein P, Moses J, Tripuraneni P, Lansky A, Jani S, Wong S, Fish D, Ellis S, Holmes D, Kerieakes D, Kuntz R. Localized Intracoronary Gamma-Radiation Therapy to Inhibit the Recurrence of Restenosis after Stenting. New England Journal Of Medicine 2001, 344: 250-256. PMID: 11172151, DOI: 10.1056/nejm200101253440402.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, Balloon, CoronaryBrachytherapyCombined Modality TherapyCoronary DiseaseCoronary ThrombosisDose-Response Relationship, RadiationDouble-Blind MethodFemaleGamma RaysHumansIridium RadioisotopesMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionPlatelet Aggregation InhibitorsRadiotherapy DosageSecondary PreventionStentsConceptsIridium-192 groupMyocardial infarctionLate thrombosisStent restenosisIridium-192Intracoronary irradiationTarget lesionsIntracoronary gamma radiation therapyMajor adverse cardiac eventsFrequency of restenosisOral antiplatelet therapyAdverse cardiac eventsComposite of deathPrimary end pointLate myocardial infarctionIntracoronary radiation therapyIncidence of deathRecurrence of restenosisGamma radiation therapyEligible patientsAngiographic restenosisAntiplatelet therapyPlacebo groupCardiac eventsCoronary angioplasty
2000
Intracoronary γ-Radiation Therapy After Angioplasty Inhibits Recurrence in Patients With In-Stent Restenosis
Waksman R, White R, Chan R, Bass B, Geirlach L, Mintz G, Satler L, Mehran R, Serruys P, Lansky A, Fitzgerald P, Bhargava B, Kent K, Pichard A, Leon M. Intracoronary γ-Radiation Therapy After Angioplasty Inhibits Recurrence in Patients With In-Stent Restenosis. Circulation 2000, 101: 2165-2171. PMID: 10801757, DOI: 10.1161/01.cir.101.18.2165.Peer-Reviewed Original ResearchConceptsStent restenosisIntracoronary gamma radiation therapyLess target lesion revascularizationBinary angiographic restenosisSuccessful coronary interventionTarget lesion revascularizationMajor cardiac eventsIndependent core laboratoryIntracoronary stent implantationInitial clinical trialsGamma radiation therapyLesion revascularizationAngiographic restenosisVessel revascularizationAngiographic outcomesCardiac eventsClinical restenosisCoronary interventionAdjunct therapyProcedural successStent implantationClinical trialsTreatment protocolNeointimal formationRadiation group