Outcome in Elderly Patients Undergoing Primary Coronary Intervention for Acute Myocardial Infarction
Guagliumi G, Stone GW, Cox DA, Stuckey T, Tcheng JE, Turco M, Musumeci G, Griffin JJ, Lansky AJ, Mehran R, Grines CL, Garcia E. Outcome in Elderly Patients Undergoing Primary Coronary Intervention for Acute Myocardial Infarction. Circulation 2004, 110: 1598-1604. PMID: 15353506, DOI: 10.1161/01.cir.0000142862.98817.1f.Peer-Reviewed Original ResearchMeSH KeywordsAbciximabAdrenergic beta-AntagonistsAdultAge FactorsAgedAged, 80 and overAngioplasty, Balloon, CoronaryAntibodies, MonoclonalAspirinCohort StudiesCombined Modality TherapyCoronary AngiographyCoronary RestenosisFemaleHemorrhageHumansImmunoglobulin Fab FragmentsLife TablesMaleMiddle AgedMyocardial InfarctionPlatelet Aggregation InhibitorsProportional Hazards ModelsPyridinesStentsStrokeTreatment OutcomeConceptsAcute myocardial infarctionGlycoprotein IIb/IIIa inhibitorsPrimary percutaneous coronary interventionIIb/IIIa inhibitorsElderly patientsPercutaneous coronary interventionMajor bleedingYears of ageCoronary interventionClinical outcomesStent implantationMyocardial infarctionPlatelet glycoprotein IIb/IIIa inhibitorsDecile of ageMechanical reperfusion strategiesOne-year mortalityPrimary coronary interventionRate of strokeCoronary stent implantationImpact of ageRate of mortalityAbciximab administrationCADILLAC trialReperfusion modalityTarget revascularizationImpact of intravenous Beta-Blockade before primary angioplasty on survival in patients undergoing mechanical reperfusion therapy for acute myocardial infarction
Halkin A, Grines CL, Cox DA, Garcia E, Mehran R, Tcheng JE, Griffin JJ, Guagliumi G, Brodie B, Turco M, Rutherford BD, Aymong E, Lansky AJ, Stone GW. Impact of intravenous Beta-Blockade before primary angioplasty on survival in patients undergoing mechanical reperfusion therapy for acute myocardial infarction. Journal Of The American College Of Cardiology 2004, 43: 1780-1787. PMID: 15145099, DOI: 10.1016/j.jacc.2003.10.068.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionAcute myocardial infarctionPrimary PCIBeta-blocker useMyocardial recoveryMyocardial infarctionLate Angioplasty Complications (CADILLAC) trialOral beta-blocker medicationOral beta-blocker useLeft ventricular ejection fractionIntravenous beta blockadeMechanical reperfusion therapyAbsence of contraindicationsBeta-blocker therapyBeta-blocker medicationBeta-blocker administrationPercutaneous coronary interventionVentricular ejection fractionBeta blockadeControlled AbciximabPrimary angioplastyReperfusion therapyComplications TrialCoronary interventionSurvival benefit