2013
Complementary prognostic utility of myocardial blush grade and ST-segment resolution after primary percutaneous coronary intervention: Analysis from the HORIZONS-AMI trial
Brener SJ, Dizon JM, Mehran R, Guerchicoff A, Lansky AJ, Farkouh M, Brodie B, Guagliumi G, Witzenbichler B, Fahy M, Parise H, Stone GW. Complementary prognostic utility of myocardial blush grade and ST-segment resolution after primary percutaneous coronary intervention: Analysis from the HORIZONS-AMI trial. American Heart Journal 2013, 166: 676-683. PMID: 24093847, DOI: 10.1016/j.ahj.2013.07.025.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionST-segment resolutionMyocardial blush gradePrimary PCIPercutaneous coronary interventionBlush gradeHORIZONS-AMIMBG 2/3Coronary interventionPrognostic utilityMajor adverse cardiac eventsMyocardial blush grade 2/3ST-elevation myocardial infarctionHORIZONS-AMI trialAdverse cardiac eventsPredictors of deathIndependent prognostic significanceComplementary prognostic informationLong-term outcomesLong-term survivalCardiac eventsReperfusion successIndependent predictorsGrade 2/3Multivariable analysisImplications of Myocardial Reperfusion on Survival in Women Versus Men With Acute Myocardial Infarction Undergoing Primary Coronary Intervention
Meller SM, Lansky AJ, Costa RA, Soffler M, Costantini CO, Brodie BR, Cox DA, Stuckey TD, Fahy M, Grines CL, Stone GW. Implications of Myocardial Reperfusion on Survival in Women Versus Men With Acute Myocardial Infarction Undergoing Primary Coronary Intervention. The American Journal Of Cardiology 2013, 112: 1087-1092. PMID: 23827398, DOI: 10.1016/j.amjcard.2013.05.052.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionMyocardial blush gradeAcute myocardial infarctionIndependent predictorsMyocardial perfusionPrimary angioplastyCoronary interventionMyocardial infarctionMyocardial Infarction 3 flowEnhanced survival benefitWomen Versus MenPrimary coronary interventionLong-term mortalityPercutaneous coronary interventionFinal ThrombolysisMBG 2/3Blush gradeLate mortalitySurvival benefitMyocardial reperfusionMyocardial salvageGender-specific responsesLate survivalInterventional strategiesMortality ratePredictors of suboptimal TIMI flow after primary angioplasty for acute myocardial infarction: results from the HORIZONS-AMI trial.
Caixeta A, Lansky AJ, Mehran R, Brener SJ, Claessen B, Généreux P, Palmerini T, Witzenbichler B, Guagliumi G, Brodie BR, Dudek D, Fahy M, Dangas GD, Stone GW. Predictors of suboptimal TIMI flow after primary angioplasty for acute myocardial infarction: results from the HORIZONS-AMI trial. EuroIntervention 2013, 9: 220-7. PMID: 23518872, DOI: 10.4244/eijv9i2a37.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAngioplasty, Balloon, CoronaryAntithrombinsChi-Square DistributionCoronary AngiographyCoronary CirculationFemaleHumansKaplan-Meier EstimateLogistic ModelsMaleMiddle AgedMyocardial InfarctionOdds RatioPlatelet Aggregation InhibitorsPredictive Value of TestsProportional Hazards ModelsProspective StudiesRecovery of FunctionRisk FactorsTime FactorsTreatment OutcomeConceptsTIMI 3 flowFinal TIMI 3 flowHORIZONS-AMI trialAcute myocardial infarctionPrimary PCITIMI flowMyocardial infarctionGlycoprotein IIb/IIIa inhibitorsIIb/IIIa inhibitorsNormal TIMI flowThree-year mortalityMulticentre prospective studyPatient-related factorsBaseline TIMIAngiographic factorsPrimary angioplastyIndependent predictorsUnfractionated heparinProspective studyAnterior MIAnatomical factorsPatientsTIMICore labLesion lengthRelationship Between ST-Segment Recovery and Clinical Outcomes After Primary Percutaneous Coronary Intervention
Farkouh ME, Reiffel J, Dressler O, Nikolsky E, Parise H, Cristea E, Baran DA, Dizon J, Merab JP, Lansky AJ, Mehran R, Stone GW. Relationship Between ST-Segment Recovery and Clinical Outcomes After Primary Percutaneous Coronary Intervention. Circulation Cardiovascular Interventions 2013, 6: 216-223. PMID: 23652600, DOI: 10.1161/circinterventions.112.000142.Peer-Reviewed Original ResearchMeSH KeywordsAgedChi-Square DistributionCoronary AngiographyElectrocardiographyFemaleFibrinolytic AgentsHumansKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionPercutaneous Coronary InterventionPlatelet Aggregation InhibitorsProportional Hazards ModelsRecovery of FunctionRisk FactorsStentsTime FactorsTreatment OutcomeConceptsPrimary percutaneous coronary interventionST-segment elevation myocardial infarctionPrimary PCIMajor adverse cardiovascular eventsST-segment resolutionAdverse cardiovascular eventsIschemia-driven target vessel revascularizationComplete ST-segment resolutionTarget vessel revascularizationPercutaneous coronary interventionMyocardial infarctionCardiovascular eventsVessel revascularizationCoronary interventionIndependent predictorsDegree of STRBaseline ST-segment elevationAcute Myocardial Infarction trialLong-term prognostic valueLong-term cardiovascular mortalityLeft ventricular ejection fractionLong-term predictive valuePost-PCI electrocardiogramsMyocardial infarction (TIMI) flowMyocardial Infarction trial
2004
Impact of intravenous Beta-Blockade before primary angioplasty on survival in patients undergoing mechanical reperfusion therapy for acute myocardial infarction
Halkin A, Grines CL, Cox DA, Garcia E, Mehran R, Tcheng JE, Griffin JJ, Guagliumi G, Brodie B, Turco M, Rutherford BD, Aymong E, Lansky AJ, Stone GW. Impact of intravenous Beta-Blockade before primary angioplasty on survival in patients undergoing mechanical reperfusion therapy for acute myocardial infarction. Journal Of The American College Of Cardiology 2004, 43: 1780-1787. PMID: 15145099, DOI: 10.1016/j.jacc.2003.10.068.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionAcute myocardial infarctionPrimary PCIBeta-blocker useMyocardial recoveryMyocardial infarctionLate Angioplasty Complications (CADILLAC) trialOral beta-blocker medicationOral beta-blocker useLeft ventricular ejection fractionIntravenous beta blockadeMechanical reperfusion therapyAbsence of contraindicationsBeta-blocker therapyBeta-blocker medicationBeta-blocker administrationPercutaneous coronary interventionVentricular ejection fractionBeta blockadeControlled AbciximabPrimary angioplastyReperfusion therapyComplications TrialCoronary interventionSurvival benefit