2008
Treatment of diffuse IN-stent restenosis with Drug-Eluting stents vs. intracoronary bEta-raDiation therapy: INDEED Study
Park SW, Lee SW, Koo B, Park DW, Lee SW, Kim YH, Lee CW, Hong MK, Kim JJ, Mori K, Lansky AJ, Mintz GS, Lee MM, Park SJ. Treatment of diffuse IN-stent restenosis with Drug-Eluting stents vs. intracoronary bEta-raDiation therapy: INDEED Study. International Journal Of Cardiology 2008, 131: 70-77. PMID: 18190986, DOI: 10.1016/j.ijcard.2007.09.003.Peer-Reviewed Original ResearchMeSH KeywordsAgedBrachytherapyCoronary RestenosisDrug-Eluting StentsFemaleFollow-Up StudiesHumansMaleMiddle AgedSirolimusConceptsMajor adverse cardiac eventsIntracoronary brachytherapySES implantationMyocardial infarctionGroup IILate lossGroup IDiffuse ISRAngiographic restenosisSirolimus-eluting stent implantationEnd pointMore effective treatment modalitiesBare-metal ISRAdverse cardiac eventsPrimary end pointSecondary end pointsEffective treatment modalityIn-Stent RestenosisDrug-eluting stentsLesion revascularizationBaseline characteristicsCardiac eventsCardiac deathLower restenosisStent implantation
2006
Predictors of Recurrent In‐Stent Restenosis after Beta‐Radiation: An Analysis from the START 40/20 Trial
KANEDA H, HONDA Y, MORINO Y, LANSKY AJ, YOCK PG, BONAN R, FITZGERALD PJ. Predictors of Recurrent In‐Stent Restenosis after Beta‐Radiation: An Analysis from the START 40/20 Trial. Journal Of Interventional Cardiology 2006, 19: 376-380. PMID: 17020560, DOI: 10.1111/j.1540-8183.2006.00188.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAnalysis of VarianceAngioplasty, Balloon, CoronaryBeta ParticlesBlood Vessel Prosthesis ImplantationBrachytherapyCoronary AngiographyCoronary Artery BypassCoronary RestenosisFemaleFollow-Up StudiesHumansMaleMiddle AgedPredictive Value of TestsProspective StudiesRadiopharmaceuticalsRecurrenceStentsStrontium RadioisotopesTreatment OutcomeUltrasonography, InterventionalYttrium RadioisotopesConceptsTarget lesion revascularizationBalloon/artery ratioLesion revascularizationRecurrent ISRGeographic missArtery ratioStent restenosisPrimary catheter-based interventionMultivariate logistic regression analysisBeta-radiation therapyPredictors of recurrentRecurrence of stenosisTreatment of ISRLarge multicenter trialsMinimum lumen diameterCatheter-based interventionsPreliminary univariate analysisLogistic regression analysisIntravascular ultrasound parametersCohort patientsIndependent predictorsMulticenter trialDiameter stenosisUnivariate analysisBalloon sizing
2005
Angiographic and clinical outcomes at 8 months of cutting balloon angioplasty and β‐brachytherapy for native vessel in‐stent restenosis (BETACUT): Results from a stopped randomized controlled trial
Schlüter M, Tübler T, Lansky AJ, Kähler S, Berger J, Mathey DG, Schofer J. Angiographic and clinical outcomes at 8 months of cutting balloon angioplasty and β‐brachytherapy for native vessel in‐stent restenosis (BETACUT): Results from a stopped randomized controlled trial. Catheterization And Cardiovascular Interventions 2005, 66: 320-326. PMID: 16216024, DOI: 10.1002/ccd.20517.Peer-Reviewed Original ResearchConceptsStandard balloonClinical outcomesCB angioplastyBalloon angioplastyStent restenosisInterim analysisMajor adverse cardiac eventsNative vesselsAdverse cardiac eventsOverall patient populationImmediate angiographic outcomeTreatment of choiceQuantitative coronary angiographyΒ-brachytherapyAngiographic restenosisBeta-radiation treatmentLesion revascularizationAngiographic outcomesCardiac eventsConsecutive patientsCoronary angiographyStudy armsIntracoronary brachytherapyPatient populationTreatment modalitiesTwo-year clinical follow-up of 90Sr/90 Y β-radiation versus placebo control for the treatment of in-stent restenosis
Silber S, Popma JJ, Suntharalingam M, Lansky AJ, Heuser RR, Speiser B, Teirstein PS, Bass T, O'Neill W, Lasala J, Reisman M, Sharma SK, Kuntz RE, Bonan R, Investigators F. Two-year clinical follow-up of 90Sr/90 Y β-radiation versus placebo control for the treatment of in-stent restenosis. American Heart Journal 2005, 149: 689-694. PMID: 15990754, DOI: 10.1016/j.ahj.2004.05.061.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryAnticoagulantsBeta ParticlesBrachytherapyCoronary AngiographyCoronary DiseaseCoronary RestenosisDiabetes ComplicationsDisease-Free SurvivalFemaleFollow-Up StudiesHumansLife TablesMaleMiddle AgedPrognosisStentsStrontium RadioisotopesThrombophiliaTreatment OutcomeYttrium RadioisotopesConceptsMajor adverse cardiac eventsTarget vessel revascularizationStent restenosisIntracoronary brachytherapyOriginal patientsPrimary safety end pointTwo-year clinical outcomesPlacebo-controlled randomized trialEnd pointAdverse cardiac eventsPlacebo-controlled studyPrimary end pointSafety end pointKaplan-Meier analysisInitial beneficial effectsRestenosis TrialVessel revascularizationCardiac eventsPlacebo armClinical followActive treatmentClinical outcomesRandomized trialsPlacebo controlPatients
2004
Favorable effect of γ‐radiation for in‐stent restenosis: Effect of diabetes on angiographic and clinical outcomes
Iakovou I, Mehran R, Dangas G, Lansky AJ, Stone GW, Mintz GS, Aymong E, Ashby DT, Pichard AD, Satler LF, Kent K, Leon MB, Waksman R. Favorable effect of γ‐radiation for in‐stent restenosis: Effect of diabetes on angiographic and clinical outcomes. Catheterization And Cardiovascular Interventions 2004, 62: 303-307. PMID: 15224295, DOI: 10.1002/ccd.20070.Peer-Reviewed Original ResearchConceptsTarget lesion revascularizationDiabetes mellitusStent restenosisMajor adverse cardiac event ratesAdverse cardiac event ratesIn-Stent Restenosis TrialLower target lesion revascularizationMajor adverse cardiac eventsNon-DM patientsAdverse cardiac eventsCardiac event rateTreatment of ISREffect of diabetesSimilar procedural successGamma radiation therapyLesion revascularizationHospital outcomesRestenosis TrialVessel revascularizationCardiac eventsProcedural successClinical outcomesWashington RadiationVascular brachytherapyPatientsGamma radiation for in‐stent restenosis: effect of lesion length on angiographic and clinical outcomes
Mehran R, Iakovou I, Dangas G, Lansky AJ, Stone GW, Mintz GS, Kent KM, Pichard AD, Satler LF, Fahy M, Leon MB, Waksman R. Gamma radiation for in‐stent restenosis: effect of lesion length on angiographic and clinical outcomes. Catheterization And Cardiovascular Interventions 2004, 61: 354-359. PMID: 14988895, DOI: 10.1002/ccd.10786.Peer-Reviewed Original ResearchConceptsISR groupLesion lengthClinical eventsIn-Stent Restenosis TrialBaseline lesion lengthLower late lossShort lesion groupTreatment of ISRStent restenosis lesionsLong-term outcomesRecurrent ISRRestenosis lesionsRestenosis TrialAngiographic outcomesISR lesionsRestenosis rateClinical outcomesWashington RadiationLate lossStent restenosisLumen dimensionsLong ISRRadiation treatmentPowerful predictorPatients
2003
Comparison of the angiographic outcomes after beta versus gamma vascular brachytherapy for treatment of in-stent restenosis
Shirai K, Lansky AJ, Mintz GS, Costantini CO, Fahy M, Mehran R, Dangas G, Moses JW, Stone GW, Waksman R, Leon MB. Comparison of the angiographic outcomes after beta versus gamma vascular brachytherapy for treatment of in-stent restenosis. The American Journal Of Cardiology 2003, 92: 1409-1413. PMID: 14675575, DOI: 10.1016/j.amjcard.2003.08.047.Peer-Reviewed Original ResearchConceptsMinimum lumen diameterVascular brachytherapyLesion lengthSegment restenosisAngiographic outcomesStent restenosisFinal minimum lumen diameterRandomized clinical trialsIndependent angiographic predictorsAngiographic restenosisPlacebo groupAngiographic predictorsAngiographic resultsMultivariable analysisNative coronariesVessel sizeClinical trialsLesion complexityVBT groupRestenosisLumen diameterSimilar reductionPlaceboGreater reductionLesionsAcute and long-term outcomes of cutting balloon angioplasty followed by gamma brachytherapy for in-stent restenosis
Kobayashi Y, Mehran R, Mintz GS, Dangas G, Moussa I, Collins M, Brara P, Moussavian M, Lansky AJ, Stone GW, Leon MB, Moses JW, Teirstein PS. Acute and long-term outcomes of cutting balloon angioplasty followed by gamma brachytherapy for in-stent restenosis. The American Journal Of Cardiology 2003, 92: 1329-1331. PMID: 14636914, DOI: 10.1016/j.amjcard.2003.08.018.Peer-Reviewed Original ResearchUsefulness of the angiographic pattern of in-stent restenosis in predicting the success of gamma vascular brachytherapy
Costantini CO, Lansky AJ, Mintz GS, Shirai K, Dangas G, Mehran R, Stone GW, Leon MB. Usefulness of the angiographic pattern of in-stent restenosis in predicting the success of gamma vascular brachytherapy. The American Journal Of Cardiology 2003, 92: 1214-1217. PMID: 14609602, DOI: 10.1016/j.amjcard.2003.07.036.Peer-Reviewed Original ResearchConceptsStent restenosisAngiographic patternsVascular brachytherapyMajor adverse cardiac event ratesAdverse cardiac event ratesBinary angiographic restenosis rateAngiographic restenosis rateCardiac event rateStent restenosis patternsRestenosis patternLesion revascularizationPrognostic roleRestenosis rateTotal occlusionClinical trialsProliferative patternEvent ratesRestenosisPooled data setBrachytherapyRevascularizationPatientsAngiogramsBaselineTrialsBeta radiation in lesions > 15 mm: a START subgroup.
Heuser R, Laskey W, Lansky A, Popma J, Bonan R. Beta radiation in lesions > 15 mm: a START subgroup. Journal Of Invasive Cardiology 2003, 15: 641-3. PMID: 14608136.Peer-Reviewed Original ResearchConceptsPlacebo groupLong lesionsStent restenosisSTART trialMajor adverse cardiac eventsAngiographic lesion characteristicsIntracoronary beta radiationAdverse cardiac eventsBinary restenosis rateIncidence of recurrentMean lesion lengthSignificant reductionLesion revascularizationRecurrent restenosisVessel revascularizationAngiographic parametersCardiac eventsClinical restenosisPatient demographicsRestenosis rateCoronary lesionsStent thrombosisLesion characteristicsRadiation groupRadiation therapyVascular brachytherapy using a beta emitter source in diabetic patients with in-stent restenosis: Angiographic and clinical outcomes
Suntharalingam M, Laskey WK, Tantibhedhyangkul W, Lansky A, Teirstein P, Bass T, Silber S, Rutherford B, Wilmer C, Popma JJ, Kuntz R, Bonan R. Vascular brachytherapy using a beta emitter source in diabetic patients with in-stent restenosis: Angiographic and clinical outcomes. International Journal Of Radiation Oncology • Biology • Physics 2003, 57: 536-542. PMID: 12957267, DOI: 10.1016/s0360-3016(03)00537-6.Peer-Reviewed Original ResearchConceptsVessel revascularization ratePercutaneous coronary interventionDiabetic patientsNondiabetic patientsVascular brachytherapyNondiabetic counterpartsStent restenosisRevascularization ratesCoronary interventionLess target lesion revascularizationConventional percutaneous coronary interventionBinary angiographic restenosisAngiographic restenosis rateTarget lesion revascularizationReference vessel diameterComplex coronary lesionsMinimal lumen diameterStudy of patientsPercent diameter stenosisVessel diameterTreatment effectsBeta-Cath SystemBreslow-Day testLesion revascularizationAngiographic restenosisUsefulness of beta radiation for de novo and In-Stent restenotic lesions in saphenous vein grafts
Stone GW, Mehran R, Midei M, Waksman R, Schaer GL, Negoita M, Lansky AJ, Buchbinder M, Investigators S. Usefulness of beta radiation for de novo and In-Stent restenotic lesions in saphenous vein grafts. The American Journal Of Cardiology 2003, 92: 312-314. PMID: 12888142, DOI: 10.1016/s0002-9149(03)00635-0.Peer-Reviewed Original ResearchLong-term follow-up of patients after gamma intracoronary brachytherapy failure (from GAMMA-I, GAMMA-II, and SCRIPPS-III)
Limpijankit T, Mehran R, Mintz GS, Dangas G, Lansky AJ, Kao J, Ashby DT, Moussa I, Stone GW, Moses JW, Leon MB, Teirstein PS. Long-term follow-up of patients after gamma intracoronary brachytherapy failure (from GAMMA-I, GAMMA-II, and SCRIPPS-III). The American Journal Of Cardiology 2003, 92: 315-318. PMID: 12888143, DOI: 10.1016/s0002-9149(03)00636-2.Peer-Reviewed Original ResearchConceptsAdverse eventsCoronary Artery Bypass GraftingTotal adverse eventsArtery Bypass GraftingCoronary artery bypassFirst-line therapyPercutaneous coronary interventionLong-term outcomesBrachytherapy failureArtery bypassBypass GraftingVessel revascularizationCoronary interventionIndependent predictorsMyocardial infarctionRadiation failureStent restenosisLate thrombosisPatientsTherapyBrachytherapyRevascularizationInfarctionThrombosisFailureImplications of the presence and length of “geographic miss” on restenosis and the edge phenomenon in the INHIBIT trial
Costantini CO, Lansky AJ, Mintz GS, Shirai K, Teirstein PS, Stone G, Vandertie L, Proctor B, Fahy M, Yeung A, Raizner AE, Waksman R, Leon MB. Implications of the presence and length of “geographic miss” on restenosis and the edge phenomenon in the INHIBIT trial. The American Journal Of Cardiology 2003, 91: 1261-1265. PMID: 12745117, DOI: 10.1016/s0002-9149(03)00280-7.Peer-Reviewed Original ResearchIntravascular brachytherapy for native coronary ostial in-stent restenotic lesions
Costantini CO, Lansky AJ, Mintz GS, Shirai K, Dangas G, Mehran R, Fahy M, Slack S, Coral M, Teirstein PS, Waksman R, Stone G, Moses J, Leon MB. Intravascular brachytherapy for native coronary ostial in-stent restenotic lesions. Journal Of The American College Of Cardiology 2003, 41: 1725-1731. PMID: 12767655, DOI: 10.1016/s0735-1097(03)00298-5.Peer-Reviewed Original ResearchConceptsAorto-ostial lesionsVascular brachytherapyRecurrence rateOstial ISRRestenosis rateStent restenosisBaseline lesion lengthStent restenotic lesionsHigh recurrence rateBinary restenosisPercutaneous reinterventionPlacebo patientsISR lesionsRestenotic lesionsQuantitative angiographyBeta patientsPatientsPooled databaseConventional treatmentRestenosisPlaceboLesionsLesion lengthBrachytherapySimilar reductionFeasibility and efficacy of tandem positioning on angiographic and clinical outcomes in the Intimal Hyperplasia Inhibition With Beta In-Stent Trial
Shirai K, Lansky AJ, Mintz GS, Costantini CO, Cristea E, Fahy M, Vandertie L, Yeung A, Raizner AE, Waksman R, Leon MB. Feasibility and efficacy of tandem positioning on angiographic and clinical outcomes in the Intimal Hyperplasia Inhibition With Beta In-Stent Trial. The American Journal Of Cardiology 2003, 91: 1113-1115. PMID: 12714158, DOI: 10.1016/s0002-9149(03)00160-7.Peer-Reviewed Original Research
2002
Long-Term Outcome of Patients Treated With Repeat Percutaneous Coronary Intervention After Failure of γ-Brachytherapy for the Treatment of In-Stent Restenosis
Prpic R, Teirstein PS, Reilly JP, Moses JW, Tripuraneni P, Lansky AJ, Giorgianni JA, Jani S, Wong SC, Fish RD, Ellis S, Holmes DR, Kereiakas D, Kuntz RE, Leon MB. Long-Term Outcome of Patients Treated With Repeat Percutaneous Coronary Intervention After Failure of γ-Brachytherapy for the Treatment of In-Stent Restenosis. Circulation 2002, 106: 2340-2345. PMID: 12403664, DOI: 10.1161/01.cir.0000036366.62288.74.Peer-Reviewed Original ResearchConceptsTarget lesion revascularizationIndex treatmentIntracoronary brachytherapyPercutaneous interventionStent restenosisAcceptable long-term resultsMajor adverse event rateRepeat percutaneous coronary interventionRepeat target vessel revascularizationSubsequent target lesion revascularizationTarget vessel revascularizationAcute procedural successAdverse event ratesPercutaneous coronary interventionIntracoronary radiation therapyLong-term outcomesLong-term resultsIn-Stent RestenosisLesion revascularizationPlacebo groupCoronary interventionFailure patientsProcedural successAngioplasty/Term outcomesDelivered Dose and Vascular Response After β-Radiation for In-Stent Restenosis
Morino Y, Kaneda H, Fox T, Takagi A, Hassan AH, Bonan R, Crocker I, Lansky AJ, Laskey WK, Suntharalingam M, Bonneau HN, Yock PG, Honda Y, Fitzgerald PJ. Delivered Dose and Vascular Response After β-Radiation for In-Stent Restenosis. Circulation 2002, 106: 2334-2339. PMID: 12403663, DOI: 10.1161/01.cir.0000036367.17043.03.Peer-Reviewed Original ResearchMeSH KeywordsBeta ParticlesBlood Vessel Prosthesis ImplantationBrachytherapyCohort StudiesCoronary AngiographyCoronary Artery DiseaseCoronary RestenosisCoronary VesselsDose-Response Relationship, RadiationFemaleHumansLinear ModelsMaleMiddle AgedRadiation DosageRadiometryRetrospective StudiesStentsTreatment OutcomeUltrasonography, InterventionalVascular PatencyConceptsIntimal hyperplasia volumeDose intensityVolumetric intravascular ultrasound analysisDose-dependent complicationsRadiation therapy trialsSerial Volumetric Intravascular Ultrasound AnalysisStent restenosis casesStent restenosis lesionsIn-Stent RestenosisIntravascular ultrasound analysisPrescribed radiation doseSource trainRestenosis casesRestenosis lesionsVascular changesVascular responsesTherapy trialsDose prescriptionLong subsegmentsDevice injuryUltrasound analysisStent segmentDoseDose rangeIVUS catheterRandomized Trial of 90Sr/90Y β-Radiation Versus Placebo Control for Treatment of In-Stent Restenosis
Popma JJ, Suntharalingam M, Lansky AJ, Heuser RR, Speiser B, Teirstein PS, Massullo V, Bass T, Henderson R, Silber S, von Rottkay P, Bonan R, Ho KK, Osattin, MPH A, Kuntz RE. Randomized Trial of 90Sr/90Y β-Radiation Versus Placebo Control for Treatment of In-Stent Restenosis. Circulation 2002, 106: 1090-1096. PMID: 12196334, DOI: 10.1161/01.cir.0000027814.96651.72.Peer-Reviewed Original ResearchConceptsTarget vessel revascularizationStent restenosisPlacebo-treated patientsPrimary end pointCatheter-based treatmentIn-Stent RestenosisPlacebo sourcesStent thrombosesAngiographic restenosisClinical restenosisFirst multicenterIntracoronary radiationMyocardial infarctionPlacebo controlPatientsPrescribed doseRestenosisConventional treatmentIntracoronary catheterEnd pointDay 244PlaceboRevascularizationTreatmentIncidenceLate Vascular Response to Repeat Stenting for In-Stent Restenosis With and Without Radiation
Morino Y, Limpijankit T, Honda Y, Lansky AJ, Waksman R, Bonneau HN, Yock PG, Mintz GS, Fitzgerald PJ. Late Vascular Response to Repeat Stenting for In-Stent Restenosis With and Without Radiation. Circulation 2002, 105: 2465-2468. PMID: 12034650, DOI: 10.1161/01.cir.0000018949.39445.40.Peer-Reviewed Original ResearchMeSH KeywordsBlood Vessel Prosthesis ImplantationBrachytherapyCohort StudiesCoronary RestenosisDisease ProgressionDouble-Blind MethodFollow-Up StudiesGamma RaysHumansIridium RadioisotopesPlatelet Aggregation InhibitorsRandomized Controlled Trials as TopicRecurrenceReoperationStentsTiclopidineTimeTreatment OutcomeUltrasonography, InterventionalVascular PatencyConceptsLumen volume indexISR lesionsPlacebo patientsLate vascular responseAcute angiographic resultsIntravascular ultrasound analysisIn-Stent RestenosisPlacebo groupAngiographic resultsVascular responsesAdditional lumenNeointimal proliferationStent restenosisIrradiated groupPatientsStent overlapLesionsVolume indexUltrasound analysisSafety of radiationLong-term advantagesStent strutsSignificant decreaseStentingRestenosis