2023
Effects of Elective Coronary Revascularization vs Medical Therapy Alone on Noncardiac Mortality A Meta-Analysis
Navarese E, Lansky A, Farkouh M, Grzelakowska K, Bonaca M, Gorog D, Raggi P, Kelm M, Yeo B, Umińska J, Curzen N, Kubica J, Wijns W, Kereiakes D. Effects of Elective Coronary Revascularization vs Medical Therapy Alone on Noncardiac Mortality A Meta-Analysis. JACC Cardiovascular Interventions 2023, 16: 1144-1156. PMID: 37225285, DOI: 10.1016/j.jcin.2023.02.030.Peer-Reviewed Original ResearchMeSH KeywordsBayes TheoremHeartHumansRandomized Controlled Trials as TopicReproducibility of ResultsSyndromeTreatment OutcomeConceptsChronic coronary syndromeElective coronary revascularizationNoncardiac mortalityMedical therapyCoronary revascularizationTrial sequential analysisCumulative Z-curveRate ratioA Meta-AnalysisRandom-effects modelMeta-analysis findingsCoronary syndromeISCHEMIA trialRandomized trialsTrial evidenceRevascularizationTreatment groupsPrespecified endpointsMeta-AnalysisPatientsMortalityFutility boundariesDeath rateTrialsTreatment effects
2021
Cardiac mortality in patients randomised to elective coronary revascularisation plus medical therapy or medical therapy alone: a systematic review and meta-analysis
Navarese EP, Lansky AJ, Kereiakes DJ, Kubica J, Gurbel PA, Gorog DA, Valgimigli M, Curzen N, Kandzari DE, Bonaca MP, Brouwer M, Umińska J, Jaguszewski MJ, Raggi P, Waksman R, Leon MB, Wijns W, Andreotti F. Cardiac mortality in patients randomised to elective coronary revascularisation plus medical therapy or medical therapy alone: a systematic review and meta-analysis. European Heart Journal 2021, 42: 4638-4651. PMID: 34002203, PMCID: PMC8669551, DOI: 10.1093/eurheartj/ehab246.Peer-Reviewed Original ResearchMeSH KeywordsCause of DeathCoronary Artery DiseaseHumansMyocardial InfarctionMyocardial RevascularizationRandomized Controlled Trials as TopicReproducibility of ResultsConceptsSpontaneous myocardial infarctionStable coronary artery disease patientsCoronary artery disease patientsElective coronary revascularisationMedical therapyCardiac mortalityMyocardial infarctionCoronary revascularisationCause mortalityDisease patientsPre-specified primary endpointCoronary artery diseaseRate ratioDeath risk reductionRandom-effects modelMultivessel diseaseMortality findingsPrimary endpointSecondary endpointsStable patientsStroke riskSurvival benefitArtery diseaseCardiac deathRevascularisation
2020
Defining device success for percutaneous coronary intervention trials: a position statement from the European Association of Percutaneous Cardiovascular Interventions of the European Society of Cardiology.
Chang CC, Kogame N, Onuma Y, Byrne RA, Capodanno D, Windecker S, Morel MA, Cutlip DE, Krucoff MW, Stone GW, Lansky AJ, Mehran R, Spitzer E, Fraser AG, Baumbach A, Serruys PW. Defining device success for percutaneous coronary intervention trials: a position statement from the European Association of Percutaneous Cardiovascular Interventions of the European Society of Cardiology. EuroIntervention 2020, 15: 1190-1198. PMID: 31475907, DOI: 10.4244/eij-d-19-00552.Peer-Reviewed Original ResearchMeSH KeywordsCoronary Artery DiseaseDrug-Eluting StentsHumansPercutaneous Coronary InterventionReproducibility of ResultsTreatment OutcomeConceptsDevice success rateDrug-eluting stentsPercutaneous coronary intervention trialsCoronary intervention trialsDevice successIntervention trialsClinical trialsSuccess rateSymptomatic coronary artery diseasePercutaneous coronary interventionAdverse clinical eventsCoronary artery diseasePercutaneous Cardiovascular InterventionsDifferent trialsRevascularisation proceduresCoronary interventionAngiographic outcomesArtery diseaseClinical eventsComparative trialsEndpoint definitionsDrug AdministrationCardiovascular interventionsPerformance endpointEuropean Association
2016
Diagnostic Accuracy of Fast Computational Approaches to Derive Fractional Flow Reserve From Diagnostic Coronary Angiography The International Multicenter FAVOR Pilot Study
Tu S, Westra J, Yang J, von Birgelen C, Ferrara A, Pellicano M, Nef H, Tebaldi M, Murasato Y, Lansky A, Barbato E, van der Heijden LC, Reiber JH, Holm NR, Wijns W, Group F. Diagnostic Accuracy of Fast Computational Approaches to Derive Fractional Flow Reserve From Diagnostic Coronary Angiography The International Multicenter FAVOR Pilot Study. JACC Cardiovascular Interventions 2016, 9: 2024-2035. PMID: 27712739, DOI: 10.1016/j.jcin.2016.07.013.Peer-Reviewed Original ResearchMeSH KeywordsAdenosineAdministration, IntravenousAgedArea Under CurveBlood Flow VelocityCardiac CatheterizationChinaComputer SimulationCoronary AngiographyCoronary StenosisCoronary VesselsEuropeFeasibility StudiesFemaleFractional Flow Reserve, MyocardialHumansHyperemiaJapanMaleMiddle AgedModels, CardiovascularMyocardial Perfusion ImagingPilot ProjectsPredictive Value of TestsPrognosisProspective StudiesRadiographic Image Interpretation, Computer-AssistedRegional Blood FlowReproducibility of ResultsROC CurveSeverity of Illness IndexTime FactorsUnited StatesVasodilator AgentsWorkflowConceptsQuantitative flow ratioHyperemic flow velocityReceiver-operating characteristic curveCoronary angiographyDiagnostic accuracyAngiographic percent diameter stenosisDiagnostic coronary angiographyProspective multicenter studyIndependent core laboratoryAdenosine-induced hyperemiaPercent diameter stenosisQuantitative coronary angiographyIntermediate coronary lesionsCharacteristic curveFractional flow reservePositive likelihood ratioOverall diagnostic accuracyNegative likelihood ratioDrug-induced hyperemiaLikelihood ratioCoronary lesionsMulticenter studyDiameter stenosisMaximal hyperemiaFlow reserve
2015
Lumen Measurements From Quantitative Coronary Angiography and IVUS: A PROSPECT Substudy
Goto K, Mintz GS, Litherland C, Lansky AJ, Weisz G, McPherson JA, De Bruyne B, Serruys PW, Stone GW, Maehara A. Lumen Measurements From Quantitative Coronary Angiography and IVUS: A PROSPECT Substudy. JACC Cardiovascular Imaging 2015, 9: 1011-1013. PMID: 26363838, DOI: 10.1016/j.jcmg.2015.07.006.Peer-Reviewed Original ResearchThe Variation in Recovery
Spatz ES, Curry LA, Masoudi FA, Zhou S, Strait KM, Gross CP, Curtis JP, Lansky AJ, Soares Barreto-Filho JA, Lampropulos JF, Bueno H, Chaudhry SI, D'Onofrio G, Safdar B, Dreyer RP, Murugiah K, Spertus JA, Krumholz HM. The Variation in Recovery. Circulation 2015, 132: 1710-1718. PMID: 26350057, PMCID: PMC4858327, DOI: 10.1161/circulationaha.115.016502.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge of OnsetAlgorithmsAortic DissectionClassificationCoronary DiseaseDiagnostic Techniques, CardiovascularFemaleHumansMaleMedical RecordsMiddle AgedMyocardial InfarctionMyocardiumOxygen ConsumptionPhenotypePlaque, AtheroscleroticProspective StudiesReproducibility of ResultsRisk FactorsSex FactorsTreatment OutcomeYoung AdultConceptsAcute myocardial infarctionCoronary artery diseaseArtery diseaseClinical phenotypeNonobstructive coronary artery diseaseYoung AMI Patients (VIRGO) studyObstructive coronary artery diseaseYoung womenType 2 acute myocardial infarctionBiological disease mechanismsSubset of patientsThird universal definitionUnique clinical phenotypeCulprit lesionClinical characteristicsMyocardial infarctionTherapeutic efficacyUniversal definitionStudy participantsPatientsSupply-demand mismatchYoung adultsDisease mechanismsPatient studiesCurrent classification schemes
2012
Clinical validation of the new T‐ and Y‐Shape models for the quantitative analysis of coronary bifurcations: An interobserver variability study
Tuinenburg JC, Janssen JP, Kooistra R, Koning G, Corral MD, Lansky AJ, Reiber JH. Clinical validation of the new T‐ and Y‐Shape models for the quantitative analysis of coronary bifurcations: An interobserver variability study. Catheterization And Cardiovascular Interventions 2012, 81: e225-e236. PMID: 22707289, DOI: 10.1002/ccd.24510.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAutomationCoronary AngiographyCoronary StenosisCoronary VesselsHumansModels, CardiovascularObserver VariationPercutaneous Coronary InterventionPredictive Value of TestsRadiographic Image Interpretation, Computer-AssistedReproducibility of ResultsStentsTomography, X-Ray ComputedTreatment OutcomeUsefulness of Noninvasive Fractional Flow Reserve Computed from Coronary Computed Tomographic Angiograms for Intermediate Stenoses Confirmed by Quantitative Coronary Angiography
Min JK, Koo BK, Erglis A, Doh JH, Daniels DV, Jegere S, Kim HS, Dunning AM, DeFrance T, Lansky A, Leipsic J. Usefulness of Noninvasive Fractional Flow Reserve Computed from Coronary Computed Tomographic Angiograms for Intermediate Stenoses Confirmed by Quantitative Coronary Angiography. The American Journal Of Cardiology 2012, 110: 971-976. PMID: 22749390, DOI: 10.1016/j.amjcard.2012.05.033.Peer-Reviewed Original ResearchConceptsLesion-specific ischemiaFractional flow reserveCoronary lesionsIntermediate stenosisFlow reservePredictive valueNoninvasive methodComputed Tomographic AngiogramsCoronary computed tomographyNoninvasive fractional flow reserveQuantitative coronary angiographyReceiver operator characteristic curveIntermediate stenosis severityNegative predictive valuePositive predictive valueOperator characteristic curveCoronary angiographyInvasive angiographyMean ageTomographic angiogramBland-Altman analysisStudy groupIschemiaComputed tomographyNovel noninvasive methodImpact of Routine Angiographic Follow-Up After Percutaneous Coronary Intervention With Drug-Eluting Stents in the SPIRIT III Randomized Trial at Three Years
Lansky AJ, Brar SS, Yaqub M, Sood P, Applegate RJ, Lazar D, Jankovic I, Hermiller JB, Koo K, Sudhir K, Stone GW. Impact of Routine Angiographic Follow-Up After Percutaneous Coronary Intervention With Drug-Eluting Stents in the SPIRIT III Randomized Trial at Three Years. The American Journal Of Cardiology 2012, 110: 21-29. PMID: 22464212, DOI: 10.1016/j.amjcard.2012.02.040.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, Balloon, CoronaryAntineoplastic Agents, PhytogenicCoronary AngiographyCoronary Artery DiseaseEverolimusFollow-Up StudiesHumansImmunosuppressive AgentsPaclitaxelProspective StudiesProsthesis DesignReproducibility of ResultsSingle-Blind MethodSirolimusTime FactorsTreatment OutcomeConceptsPaclitaxel-eluting stentsID-TLRAngiographic groupClinical followMajor adverse cardiovascular event ratesAdverse cardiovascular event ratesDrug-eluting stent placementMajor adverse cardiovascular eventsBare metal stent implantationSPIRIT IIILandmark survival analysisSPIRIT III trialAdverse cardiovascular eventsSafety end pointCardiovascular event ratesIschemia-driven revascularizationMajor clinical outcomesPercutaneous coronary interventionDrug-eluting stentsRoutine AngiographicCardiovascular eventsCoronary revascularizationRevascularization ratesCoronary interventionIII trialsWhole Blood Gene Expression Testing for Coronary Artery Disease in Nondiabetic Patients: Major Adverse Cardiovascular Events and Interventions in the PREDICT Trial
Rosenberg S, Elashoff MR, Lieu HD, Brown BO, Kraus WE, Schwartz RS, Voros S, Ellis SG, Waksman R, McPherson JA, Lansky AJ, Topol EJ, for the PREDICT Investigators. Whole Blood Gene Expression Testing for Coronary Artery Disease in Nondiabetic Patients: Major Adverse Cardiovascular Events and Interventions in the PREDICT Trial. Journal Of Cardiovascular Translational Research 2012, 5: 366-374. PMID: 22396313, PMCID: PMC3349850, DOI: 10.1007/s12265-012-9353-z.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAngioplasty, Balloon, CoronaryCoronary AngiographyCoronary Artery BypassCoronary Artery DiseaseFemaleGene Expression RegulationGenetic Predisposition to DiseaseGenetic TestingHumansIschemic Attack, TransientLogistic ModelsMaleMiddle AgedMyocardial InfarctionOdds RatioPhenotypePredictive Value of TestsPrognosisProspective StudiesReproducibility of ResultsRisk AssessmentRisk FactorsStrokeTime FactorsUnited StatesConceptsMajor adverse cardiovascular eventsCoronary artery diseaseObstructive coronary artery diseaseGene expression scoreAdverse cardiovascular eventsCardiovascular eventsArtery diseaseClinical risk scoreGroup of patientsNegative predictive valueGene expression testingNondiabetic patientsPREDICT trialAngiography patientsGES groupPREDICT studyRisk scorePatientsPredictive valueExpression scoreRevascularizationEvent ratesDiseaseMonthsExpression testing
2011
SYNTAX Score Reproducibility and Variability Between Interventional Cardiologists, Core Laboratory Technicians, and Quantitative Coronary Measurements
Généreux P, Palmerini T, Caixeta A, Cristea E, Mehran R, Sanchez R, Lazar D, Jankovic I, Corral MD, Dressler O, Fahy MP, Parise H, Lansky AJ, Stone GW. SYNTAX Score Reproducibility and Variability Between Interventional Cardiologists, Core Laboratory Technicians, and Quantitative Coronary Measurements. Circulation Cardiovascular Interventions 2011, 4: 553-561. PMID: 22028472, DOI: 10.1161/circinterventions.111.961862.Peer-Reviewed Original ResearchConceptsQuantitative coronary angiographyAngiographic core laboratorySYNTAX scoreInterventional cardiologistsComplex coronary artery diseaseCardiac Surgery (SYNTAX) trialPercutaneous coronary interventionCoronary artery diseaseSmall vessel diseaseFuture clinical trialsQuantitative coronary measurementsNumber of lesionsAdditional angiogramsCoronary interventionArtery diseaseCoronary angiographySurgery TrialClinical trialsClinical utilityCoronary measurementsIntensive training sessionCore laboratoryLesion typeRoutine practiceScore reproducibilityDiscrepancy in the assessment of jailed side branch lesions by visual estimation and quantitative coronary angiographic analysis
Shin D, Koo B, Waseda K, Park KW, Kim H, Corral M, Lansky A, Honda Y, Fearon WF, Fitzgerald PJ. Discrepancy in the assessment of jailed side branch lesions by visual estimation and quantitative coronary angiographic analysis. Catheterization And Cardiovascular Interventions 2011, 78: 720-726. PMID: 22025472, DOI: 10.1002/ccd.23049.Peer-Reviewed Original ResearchConceptsMean minimum lumen diameterQuantitative coronary angiographyFractional flow reserveSide branch lesionsDiameter stenosisSB lesionsIntraclass correlation coefficientBranch lesionsQuantitative coronary angiographic analysisCoronary angiographic analysisMinimum lumen diameterVisual estimationCoronary angiographyPressure trialAngiographic analysisAngiographic assessmentFlow reserveCore laboratoryStenosisReference diameterLesionsLumen diameterLesion lengthFunctional significance
2010
Intravascular Ultrasound Classification of Plaque Distribution in Left Main Coronary Artery Bifurcations
Oviedo C, Maehara A, Mintz GS, Araki H, Choi SY, Tsujita K, Kubo T, Doi H, Templin B, Lansky AJ, Dangas G, Leon MB, Mehran R, Tahk SJ, Stone GW, Ochiai M, Moses JW. Intravascular Ultrasound Classification of Plaque Distribution in Left Main Coronary Artery Bifurcations. Circulation Cardiovascular Interventions 2010, 3: 105-112. PMID: 20197513, DOI: 10.1161/circinterventions.109.906016.Peer-Reviewed Original ResearchMeSH KeywordsAgedCoronary AngiographyCoronary StenosisHumansMaleMiddle AgedReproducibility of ResultsRetrospective StudiesSensitivity and SpecificityUltrasonography, InterventionalConceptsLCX arteryMain coronary artery bifurcationLeft main coronary artery bifurcationIntravascular ultrasoundPlaque distributionCoronary artery bifurcationsAngiographic classificationArtery bifurcationLAD arteryBifurcation lesionsDistal LMCACircumflex artery lesionsLMCA bifurcation lesionsPreintervention intravascular ultrasoundProximal LAD arteryAngiographic diameter stenosisSeverity of diseaseIVUS plaque burdenLMCA lengthArtery lesionsAnterior descendingPlaque burdenDiameter stenosisBifurcation diseaseLCX ostium
2009
New approaches for the assessment of vessel sizes in quantitative (cardio-)vascular X-ray analysis
Janssen JP, Rares A, Tuinenburg JC, Koning G, Lansky AJ, Reiber JH. New approaches for the assessment of vessel sizes in quantitative (cardio-)vascular X-ray analysis. The International Journal Of Cardiovascular Imaging 2009, 26: 259-271. PMID: 19888671, PMCID: PMC2846330, DOI: 10.1007/s10554-009-9526-2.Peer-Reviewed Original Research
2008
Quantitative angiographic methods for bifurcation lesions : A consensus statement from the European Bifurcation Group
Lansky A, Tuinenburg J, Costa M, Maeng M, Koning G, Popma J, Cristea E, Gavit L, Costa R, Rares A, Van Es G, Lefevre T, Reiber H, Louvard Y, Morice M. Quantitative angiographic methods for bifurcation lesions : A consensus statement from the European Bifurcation Group. Catheterization And Cardiovascular Interventions 2008, 73: 258-266. PMID: 19085918, DOI: 10.1002/ccd.21814.Peer-Reviewed Original Research
2007
Assessing intermediate left main coronary lesions using intravascular ultrasound
Sano K, Mintz GS, Carlier SG, de Ribamar Costa J, Qian J, Missel E, Shan S, Franklin-Bond T, Boland P, Weisz G, Moussa I, Dangas GD, Mehran R, Lansky AJ, Kreps EM, Collins MB, Stone GW, Leon MB, Moses JW. Assessing intermediate left main coronary lesions using intravascular ultrasound. American Heart Journal 2007, 154: 983-988. PMID: 17967608, DOI: 10.1016/j.ahj.2007.07.001.Peer-Reviewed Original ResearchConceptsLeft main coronary artery stenosisQuantitative coronary angiographySignificant left main coronary artery stenosisMinimal lumen areaIntravascular ultrasoundOstial lesionsIVUS analysisMain coronary artery stenosisLumen areaIVUS minimal lumen areaLeft main ostiumAmbiguous left main coronary artery stenosisCoronary artery stenosisMain coronary lesionsMinimal lumen diameterIVUS evaluationConsecutive patientsCoronary angiographyCoronary lesionsSuch patientsArtery stenosisPlaque burdenDiameter stenosisMain ostiumPhysiologic assessment
2005
Intravascular Ultrasonic Assessment of Stent Diameters Derived from Manufacturer’s Compliance Charts
de Ribamar Costa J, Mintz GS, Carlier SG, Costa RA, Fujii K, Sano K, Kimura M, Lui J, Weisz G, Moussa I, Dangas G, Mehran R, Lansky AJ, Kreps EM, Collins M, Stone GW, Moses JW, Leon MB. Intravascular Ultrasonic Assessment of Stent Diameters Derived from Manufacturer’s Compliance Charts. The American Journal Of Cardiology 2005, 96: 74-78. PMID: 15979438, DOI: 10.1016/j.amjcard.2005.02.049.Peer-Reviewed Original ResearchConceptsManufacturers' compliance chartsMinimum stent diameterCompliance chartsStent diameterIntravascular ultrasoundStent sizeDe novo coronary lesionsDeployment pressureNovo coronary lesionsMinimal stent diameterHuman coronary arteriesStent manufacturersCoronary lesionsIVUS guidanceCoronary arteryStent lengthInterventional cardiologistsPhysician reportsPercutaneous proceduresStent overlapDifferent stent lengthsStentsBoston ScientificUltrasonic assessmentBare metal
2004
A simple risk score for prediction of contrast-induced nephropathy after percutaneous coronary interventionDevelopment and initial validation
MEHRAN R, AYMONG E, NIKOLSKY E, LASIC Z, IAKOVOU I, FAHY M, MINTZ G, LANSKY A, MOSES J, STONE G. A simple risk score for prediction of contrast-induced nephropathy after percutaneous coronary interventionDevelopment and initial validation. Journal Of The American College Of Cardiology 2004, 44: 1393-1399. DOI: 10.1016/s0735-1097(04)01445-7.Peer-Reviewed Original ResearchA simple risk score for prediction of contrast-induced nephropathy after percutaneous coronary intervention Development and initial validation
Mehran R, Aymong E, Nikolsky E, Lasic Z, Iakovou I, Fahy M, Mintz G, Lansky A, Moses J, Stone G, Leon M, Dangas G. A simple risk score for prediction of contrast-induced nephropathy after percutaneous coronary intervention Development and initial validation. Journal Of The American College Of Cardiology 2004, 44: 1393-1399. PMID: 15464318, DOI: 10.1016/j.jacc.2004.06.068.Peer-Reviewed Original ResearchConceptsContrast-induced nephropathyPercutaneous coronary interventionSimple risk scoreRisk scoreRate of CINRisk of CINCandidate univariate predictorsMultivariate logistic regressionTotal risk scoreGood discriminative powerWeighted integerCoronary interventionIndependent predictorsUnivariate predictorsRisk factorsOdds ratioProcedural characteristicsCumulative riskPatientsLogistic regressionIntervention developmentOverall occurrenceInvestigational purposesNephropathyScores
2002
Impact of normalized myocardial perfusion after successful angioplasty in acute myocardial infarction
Stone GW, Peterson MA, Lansky AJ, Dangas G, Mehran R, Leon MB. Impact of normalized myocardial perfusion after successful angioplasty in acute myocardial infarction. Journal Of The American College Of Cardiology 2002, 39: 591-597. PMID: 11849856, DOI: 10.1016/s0735-1097(01)01779-x.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionTIMI 3 flowAcute myocardial infarctionMyocardial infarctionMyocardial perfusionMyocardial blushSuccessful angioplastyAngiographic myocardial blush gradeOne-year cumulative mortalityEpicardial coronary flowMyocardial blush scoreNormal myocardial blushHigh-risk featuresHigh-risk patientsMyocardial blush gradeAbnormal myocardial perfusionMyocardial perfusion gradePercutaneous coronary interventionSurvival of patientsNormal myocardial perfusionTIMI 0Blush gradeCardiogenic shockInfarct arteryCoronary intervention