Effect of Supersaturated Oxygen Delivery on Infarct Size After Percutaneous Coronary Intervention in Acute Myocardial Infarction
Stone GW, Martin JL, de Boer MJ, Margheri M, Bramucci E, Blankenship JC, Metzger DC, Gibbons RJ, Lindsay BS, Weiner BH, Lansky AJ, Krucoff MW, Fahy M, Boscardin WJ. Effect of Supersaturated Oxygen Delivery on Infarct Size After Percutaneous Coronary Intervention in Acute Myocardial Infarction. Circulation Cardiovascular Interventions 2009, 2: 366-375. PMID: 20031745, DOI: 10.1161/circinterventions.108.840066.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionMajor adverse cardiovascular eventsElevation myocardial infarctionPercutaneous coronary interventionAdverse cardiovascular eventsAnterior ST-segment elevation myocardial infarctionInfarct sizeCoronary interventionMyocardial infarctionCardiovascular eventsLeft anteriorSymptom onsetLarge ST-segment elevation myocardial infarctionComposite major adverse cardiovascular eventsSestamibi single-photon emissionMedian infarct sizePosthoc subgroup analysisPrimary efficacy measureAcute myocardial infarctionPrimary safety measureSingle photon emissionNoninferior ratesTreat populationProtocol populationMulticenter trialAssociations of major bleeding and myocardial infarction with the incidence and timing of mortality in patients presenting with non-ST-elevation acute coronary syndromes: a risk model from the ACUITY trial
Mehran R, Pocock SJ, Stone GW, Clayton TC, Dangas GD, Feit F, Manoukian SV, Nikolsky E, Lansky AJ, Kirtane A, White HD, Colombo A, Ware JH, Moses JW, Ohman EM. Associations of major bleeding and myocardial infarction with the incidence and timing of mortality in patients presenting with non-ST-elevation acute coronary syndromes: a risk model from the ACUITY trial. European Heart Journal 2009, 30: 1457-1466. PMID: 19351691, PMCID: PMC2695951, DOI: 10.1093/eurheartj/ehp110.Peer-Reviewed Original ResearchConceptsAcute coronary syndromeMajor bleedingMyocardial infarctionBaseline predictorsMortality riskMajor bleedsCoronary syndromeHigh-risk acute coronary syndromesUrgent Intervention Triage Strategy (ACUITY) trialElevation acute coronary syndromeMultivariable Cox regression modelsDays of randomizationTime-updated covariatesRecurrent myocardial infarctionIndependent baseline predictorsCox regression modelShort-term riskTiming of mortalityACUITY trialAcute CatheterizationHazard ratioStrategy trialBleedingMortality hazardCox model