2011
5-Year Follow-Up of Polytetrafluoroethylene-Covered Stents Compared With Bare-Metal Stents in Aortocoronary Saphenous Vein Grafts The Randomized BARRICADE (Barrier Approach to Restenosis: Restrict Intima to Curtail Adverse Events) Trial
Stone GW, Goldberg S, O'Shaughnessy C, Midei M, Siegel RM, Cristea E, Dangas G, Lansky AJ, Mehran R. 5-Year Follow-Up of Polytetrafluoroethylene-Covered Stents Compared With Bare-Metal Stents in Aortocoronary Saphenous Vein Grafts The Randomized BARRICADE (Barrier Approach to Restenosis: Restrict Intima to Curtail Adverse Events) Trial. JACC Cardiovascular Interventions 2011, 4: 300-309. PMID: 21435608, DOI: 10.1016/j.jcin.2010.11.013.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryChi-Square DistributionCoated Materials, BiocompatibleCoronary AngiographyCoronary Artery BypassCoronary RestenosisFemaleGraft Occlusion, VascularHumansKaplan-Meier EstimateMaleMetalsMiddle AgedMyocardial InfarctionPlatelet Aggregation InhibitorsPolytetrafluoroethyleneProspective StudiesProsthesis DesignRisk AssessmentRisk FactorsSaphenous VeinStentsThrombosisTime FactorsTreatment OutcomeUnited StatesConceptsSaphenous vein graftsBare metal stentsPercutaneous coronary interventionDiseased saphenous vein graftsHigh-pressure implantationDual antiplatelet therapyTarget vessel failureAntiplatelet therapyMajor secondary end pointEnd pointPrimary end pointSecondary end pointsLong-term prognosisBinary restenosisBMS patientsCoronary interventionVein graftsVessel failureInferior outcomesSaphenous veinDiscrete lesionsPatientsPrior trialsJostentLesions
2007
Short- and Long-Term Outcomes After Stent-Assisted Percutaneous Treatment of Saphenous Vein Grafts in the Drug-Eluting Stent Era
Pucelikova T, Mehran R, Kirtane AJ, Kim YH, Fahy M, Weisz G, Lansky AJ, Moussa I, Gray WA, Collins MB, Kodali SK, Stone GW, Moses JW, Leon MB, Dangas G. Short- and Long-Term Outcomes After Stent-Assisted Percutaneous Treatment of Saphenous Vein Grafts in the Drug-Eluting Stent Era. The American Journal Of Cardiology 2007, 101: 63-68. PMID: 18157967, DOI: 10.1016/j.amjcard.2007.07.048.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryCoronary AngiographyCoronary Artery BypassFemaleFollow-Up StudiesGraft Occlusion, VascularHumansMaleMultivariate AnalysisMyocardial InfarctionMyocardiumNecrosisPaclitaxelProspective StudiesProsthesis DesignRegistriesRetreatmentSaphenous VeinSirolimusStentsThrombosisConceptsMajor adverse cardiac eventsAdverse cardiac eventsPercutaneous coronary interventionDrug-eluting stentsSVG lesionsVessel revascularizationCardiac eventsCoronary interventionPercutaneous treatmentMyocardial infarctionStent-assisted percutaneous coronary interventionSaphenous vein graft lesionsNative vessel diseasePeriprocedural myocardial necrosisTarget lesion revascularizationTarget vessel revascularizationSaphenous vein graftsVein graft lesionsPresence of thrombusEmbolic protection devicesHigh-risk subgroupsLong-term outcomesContemporary clinical practiceLesion revascularizationStent thrombosesProspective, Multicenter Study of Thrombectomy in Patients with Acute Myocardial Infarction: The X‐Tract AMI Registry
YOUNG JJ, COX DA, STUCKEY T, BABB J, TURCO M, LANSKY AJ, MEHRAN R, STONE GW. Prospective, Multicenter Study of Thrombectomy in Patients with Acute Myocardial Infarction: The X‐Tract AMI Registry. Journal Of Interventional Cardiology 2007, 20: 44-50. PMID: 17300402, DOI: 10.1111/j.1540-8183.2007.00223.x.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, Balloon, CoronaryCanadaCardiac CatheterizationCoronary ThrombosisCoronary VesselsFemaleGraft Occlusion, VascularHumansMaleMiddle AgedMyocardial InfarctionMyocardial ReperfusionPostoperative ComplicationsProspective StudiesRegistriesSaphenous VeinSeverity of Illness IndexStentsThrombectomyTreatment OutcomeUnited StatesConceptsSaphenous vein graftsAcute myocardial infarctionNative coronary arteriesPrimary angioplastyCoronary arteryAMI registryMulticenter studyMyocardial infarctionGlycoprotein IIb/IIIa inhibitorsMyocardial blush grade 3IIb/IIIa inhibitorsDiseased saphenous vein graftsTIMI 0/1 flowMajor cardiovascular eventsTIMI 3 flowMajority of patientsEpicardial blood flowBare metal stentsCardiovascular eventsThrombectomy systemDistal embolizationMulticenter experienceThromboembolic complicationsVein graftsMyocardial blush
2006
Intravascular Ultrasonic Differences Between Aorto-Ostial and Shaft Narrowing in Saphenous Veins Used as Aortocoronary Bypass Grafts
Sano K, Mintz GS, Carlier SG, Fujii K, Yasuda T, Kimura M, Costa JR, Costa RA, Lui J, Weisz G, Moussa I, Dangas GD, Mehran R, Lansky AJ, Kreps EM, Collins M, Stone GW, Moses JW, Leon MB. Intravascular Ultrasonic Differences Between Aorto-Ostial and Shaft Narrowing in Saphenous Veins Used as Aortocoronary Bypass Grafts. The American Journal Of Cardiology 2006, 97: 1463-1466. PMID: 16679084, DOI: 10.1016/j.amjcard.2005.11.080.Peer-Reviewed Original ResearchConceptsMinimal lumen areaAorto-ostial lesionsPositive remodelingShaft lesionsLumen areaPlaque burdenDistal referenceSoft plaqueAortocoronary bypass graftsLarger plaque burdenSVG lesionsComplication rateBypass graftInterventional complicationsSaphenous veinLesion locationLesionsMorphologic differencesRemodelingPlaquesIVUS dataLocation-specific differencesBurdenIntravascular ultrasound imagesPrevious studies
2004
Prognostic significance of cerebrovascular and peripheral arterial disease in patients having percutaneous coronary interventions
Nikolsky E, Mehran R, Dangas GD, Lasic Z, Mintz GS, Negoita M, Lansky AJ, Stone GW, Moussa I, Iyer S, Na Y, Moses JW, Leon MB. Prognostic significance of cerebrovascular and peripheral arterial disease in patients having percutaneous coronary interventions. The American Journal Of Cardiology 2004, 93: 1536-1539. PMID: 15194030, DOI: 10.1016/j.amjcard.2004.03.010.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAngioplasty, Balloon, CoronaryBody Mass IndexCase-Control StudiesCerebrovascular DisordersCoronary Artery DiseaseDiabetes ComplicationsFemaleHospital MortalityHumansKidney Failure, ChronicLength of StayLogistic ModelsMaleMiddle AgedMultivariate AnalysisPeripheral Vascular DiseasesPrognosisSaphenous VeinSex FactorsRelation of final lumen dimensions in saphenous vein grafts after stent implantation to outcome
Iakovou I, Dangas G, Mintz GS, Mehran R, Kobayashi Y, Aymong E, Hirose M, Ashby DT, Lansky AJ, Stone GW, Leon MB, Moses JW. Relation of final lumen dimensions in saphenous vein grafts after stent implantation to outcome. The American Journal Of Cardiology 2004, 93: 963-968. PMID: 15081436, DOI: 10.1016/j.amjcard.2003.12.049.Peer-Reviewed Original ResearchConceptsSaphenous vein graftsAggressive stent expansionSVG lesionsStent expansionVein graftsMyocardial infarctionStent implantationHospital non-Q-wave myocardial infarctionLumen dimensionsGroup IINon-Q-wave myocardial infarctionIntravascular ultrasound-guided stentingTarget vessel revascularization rateVessel revascularization rateBaseline patient characteristicsMyocardial infarction rateNative coronary lesionsStent cross-sectional areaTarget vessel revascularizationPercutaneous coronary interventionNative coronary arteriesCross-sectional areaLower restenosis rateRevascularization ratesVessel revascularization
2003
Prospective, randomized evaluation of thrombectomy prior to percutaneous intervention in diseased saphenous vein grafts and thrombus-containing coronary arteries
Stone GW, Cox DA, Babb J, Nukta D, Bilodeau L, Cannon L, Stuckey TD, Hermiller J, Cohen EA, Low R, Bailey SR, Lansky AJ, Kuntz RE, Investigators F. Prospective, randomized evaluation of thrombectomy prior to percutaneous intervention in diseased saphenous vein grafts and thrombus-containing coronary arteries. Journal Of The American College Of Cardiology 2003, 42: 2007-2013. PMID: 14662267, DOI: 10.1016/j.jacc.2003.10.001.Peer-Reviewed Original ResearchConceptsDiseased saphenous vein graftsSaphenous vein graftsNative coronary arteriesPeri-procedural myocardial infarctionEvent-free survivalCoronary arteryMyocardial infarctionControl patientsStent implantationRoutine thrombectomyVein graftsSize patientsLate event-free survivalMajor adverse cardiac eventsPeri-procedural myonecrosisAdverse cardiac eventsHigh-risk patientsPercutaneous coronary interventionLarge myocardial infarctionSafety of interventionsPrior thrombectomyCardiac eventsCoronary interventionPercutaneous interventionLate outcomesUsefulness of beta radiation for de novo and In-Stent restenotic lesions in saphenous vein grafts
Stone GW, Mehran R, Midei M, Waksman R, Schaer GL, Negoita M, Lansky AJ, Buchbinder M, Investigators S. Usefulness of beta radiation for de novo and In-Stent restenotic lesions in saphenous vein grafts. The American Journal Of Cardiology 2003, 92: 312-314. PMID: 12888142, DOI: 10.1016/s0002-9149(03)00635-0.Peer-Reviewed Original ResearchSafety and efficacy of a novel device for treatment of thrombotic and atherosclerotic lesions in native coronary arteries and saphenous vein grafts: Results from the multicenter X‐sizer for treatment of thrombus and atherosclerosis in coronary applications trial (X‐TRACT) study
Stone GW, Cox DA, Low R, Cates CU, Satler L, Bailey SR, Kuntz RE, Lansky AJ. Safety and efficacy of a novel device for treatment of thrombotic and atherosclerotic lesions in native coronary arteries and saphenous vein grafts: Results from the multicenter X‐sizer for treatment of thrombus and atherosclerosis in coronary applications trial (X‐TRACT) study. Catheterization And Cardiovascular Interventions 2003, 58: 419-427. PMID: 12652487, DOI: 10.1002/ccd.10511.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryAtherectomy, CoronaryChi-Square DistributionCoronary AngiographyCoronary Artery DiseaseCoronary ThrombosisEquipment DesignEquipment SafetyFemaleFollow-Up StudiesGraft Occlusion, VascularHumansMaleMiddle AgedProbabilityRisk AssessmentSaphenous VeinStatistics, NonparametricStentsThrombectomyTreatment OutcomeConceptsSaphenous vein graftsNative coronary arteriesVein graftsX-SizerThrombotic lesionsCoronary arteryNon-Q-wave MIDistal branch occlusionTIMI 3 flowSide branch occlusionTreatment of thrombusDistal thromboemboliPeriprocedural MITIMI 0Adverse eventsThromboembolic complicationsConsecutive patientsAntegrade flowBranch occlusionPercutaneous interventionHistorical controlsAtherosclerotic lesionsTrial studyU.S. CentersLesions
2001
Are we making progress with percutaneous saphenous vein graft treatment? A comparison of 1990 to 1994 and 1995 to 1998 results
Hong M, Mehran R, Dangas G, Mintz G, Lansky A, Kent K, Pichard A, Satler L, Stone G, Leon M. Are we making progress with percutaneous saphenous vein graft treatment? A comparison of 1990 to 1994 and 1995 to 1998 results. Journal Of The American College Of Cardiology 2001, 38: 150-154. PMID: 11451265, DOI: 10.1016/s0735-1097(01)01324-9.Peer-Reviewed Original ResearchConceptsLate cardiac eventsSVG lesionsCardiac eventsDistal embolizationStent useSaphenous vein graft angioplastyUnfavorable lesion characteristicsVein graft angioplastyOne-year outcomesProcedural success rateHigh procedural successHigh-risk lesionsGraft angioplastySVG angioplastyLate mortalityRepeat revascularizationBaseline characteristicsProcedural successRisk lesionsFavorable outcomeLesion characteristicsGraft treatmentMultivariate analysisAngioplastyLesionsInfluence of gender on early and one-year clinical outcomes after saphenous vein graft stenting
Ahmed J, Dangas G, Lansky A, Mehran R, Hong M, Mintz G, Pichard A, Satler L, Kent K, Stone G, Leon M. Influence of gender on early and one-year clinical outcomes after saphenous vein graft stenting. The American Journal Of Cardiology 2001, 87: 401-405. PMID: 11179522, DOI: 10.1016/s0002-9149(00)01391-6.Peer-Reviewed Original ResearchConceptsAcute renal failureClinical outcomesSVG lesionsHospital mortalityVascular complicationsRenal failureProcedural successStent implantationFemale genderOne-year clinical outcomesSaphenous vein graft stentingLate clinical outcomesOverall procedural successSaphenous vein graftsVentricular ejection fractionInfluence of genderMultivariate regression analysisGraft stentingLesion revascularizationCoronary revascularizationConsecutive patientsDiabetes mellitusEjection fractionHospital eventsVein grafts
2000
Acute and long-term results of treatment of diffuse in-stent restenosis in aortocoronary saphenous vein grafts
Dangas G, Mehran R, Lansky A, Waksman R, Satler L, Pichard A, Kent K, Mintz G, Stone G, Leon M. Acute and long-term results of treatment of diffuse in-stent restenosis in aortocoronary saphenous vein grafts. The American Journal Of Cardiology 2000, 86: 777-779. PMID: 11018200, DOI: 10.1016/s0002-9149(00)01080-8.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnalysis of VarianceAngioplasty, Balloon, CoronaryAngioplasty, Balloon, Laser-AssistedCombined Modality TherapyCoronary Artery BypassCoronary Artery DiseaseFemaleGraft Occlusion, VascularHumansHyperplasiaMaleRecurrenceRisk FactorsSaphenous VeinStentsTreatment OutcomeUltrasonography, InterventionalConceptsSaphenous vein graftsVein graftsStent restenosisAortocoronary saphenous vein graftsHigher long-term mortalityExcimer laser coronary angioplastyAdjunct balloon angioplastyLong-term mortalityLaser coronary angioplastyTreatment of diffuseLong-term resultsRepeat revascularizationCoronary angioplastyAcute resultsBalloon angioplastyFrequent needAngioplastyRestenosisGraftTreatmentRevascularizationMortalityPrognostic value of cardiac troponin-I levels following catheter-based coronary interventions
Fuchs S, Kornowski R, Mehran R, Lansky A, Satler L, Pichard A, Kent K, Clark C, Stone G, Leon M. Prognostic value of cardiac troponin-I levels following catheter-based coronary interventions. The American Journal Of Cardiology 2000, 85: 1077-1082. PMID: 10781755, DOI: 10.1016/s0002-9149(00)00699-8.Peer-Reviewed Original ResearchConceptsCatheter-based coronary interventionsCK-MB levelsHospital complicationsCoronary interventionCreatine kinase-MB fraction levelsCardiac event-free survivalIntermediate-term clinical outcomesTn-I levelsEvent-free survivalIntermediate-term outcomesRisk of mortalityQ-wave infarctionLesion revascularizationConsecutive patientsCoronary angioplastyIndependent predictorsClinical outcomesPrognostic significancePrognostic valueCoronary arteryMyocardial infarctionPlasma levelsSaphenous veinNormal limitsGroup IIProcedural results and intermediate clinical outcomes after multiple saphenous vein graft stenting
Bhargava B, Kornowski R, Mehran R, Kent K, Hong M, Lansky A, Waksman R, Pichard A, Satler L, Leon M. Procedural results and intermediate clinical outcomes after multiple saphenous vein graft stenting. Journal Of The American College Of Cardiology 2000, 35: 389-397. PMID: 10676686, DOI: 10.1016/s0735-1097(99)00564-1.Peer-Reviewed Original ResearchConceptsMid-term clinical outcomesSVG interventionClinical outcomesProcedural successOverall cardiac event-free survivalCardiac event-free survivalSaphenous vein graft angioplastyNon-Q-wave MIHospital procedural successVein graft angioplastyEvent-free survivalIntermediate clinical outcomesMajor complication rateOverall procedural successSaphenous vein graftsGraft angioplastyLesion revascularizationSimultaneous stentingSVG diseaseSVG groupSVG stentingLate mortalityComplication rateDistal embolizationMI ratesComparison of time course of target lesion revascularization following successful saphenous vein graft angioplasty versus successful native coronary angioplasty
Hong M, Mehran R, Dangas G, Mintz G, Lansky A, Kent K, Pichard A, Satler L, Stone G, Leon M. Comparison of time course of target lesion revascularization following successful saphenous vein graft angioplasty versus successful native coronary angioplasty. The American Journal Of Cardiology 2000, 85: 256-258. PMID: 10955387, DOI: 10.1016/s0002-9149(99)00634-7.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplastyCoronary DiseaseFemaleHumansMaleRemission InductionSaphenous VeinTime Factors
1999
Creatine Kinase-MB Enzyme Elevation Following Successful Saphenous Vein Graft Intervention Is Associated With Late Mortality
Hong M, Mehran R, Dangas G, Mintz G, Lansky A, Pichard A, Kent K, Satler L, Stone G, Leon M. Creatine Kinase-MB Enzyme Elevation Following Successful Saphenous Vein Graft Intervention Is Associated With Late Mortality. Circulation 1999, 100: 2400-2405. PMID: 10595951, DOI: 10.1161/01.cir.100.24.2400.Peer-Reviewed Original ResearchConceptsCK-MB elevationSaphenous vein graft interventionCK-MB riseVein graft interventionLate mortalityGraft interventionClinical eventsCreatine kinase‐MB enzyme elevationPeriprocedural CK-MB elevationNormal CK-MBMajor clinical eventsLate clinical eventsCreatine kinase elevationStrong independent predictorHospital complicationsSVG angioplastySVG interventionSVG lesionsConsecutive patientsDiabetes mellitusEnzyme elevationIndependent predictorsPrognostic significanceCK-MBMultivariate analysisLow- versus high-dose recombinant urokinase for the treatment of chronic saphenous vein graft occlusion
Teirstein P, Mann J, Cundey P, Schechter E, Jacobs W, Grines C, Stagaman D, Lansky A, Hultquist M, Kusnick B, Heuser R, Kleinert H, Popma J. Low- versus high-dose recombinant urokinase for the treatment of chronic saphenous vein graft occlusion. The American Journal Of Cardiology 1999, 83: 1623-1628. PMID: 10392865, DOI: 10.1016/s0002-9149(99)00163-0.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnticoagulantsCerebral HemorrhageChronic DiseaseCoronary AngiographyCoronary DiseaseDose-Response Relationship, DrugFemaleGraft Occlusion, VascularHeparinHumansInfusions, IntravenousMaleMiddle AgedPlasminogen ActivatorsRecombinant ProteinsSaphenous VeinUrokinase-Type Plasminogen ActivatorConceptsSaphenous vein graftsR-UKStudy drugVein graftsMyocardial infarctionNon-Q-wave myocardial infarctionPrimary study end pointSaphenous vein graft occlusionHigh-dose armStudy end pointLife-threatening bleedingVein graft occlusionHigh-dose groupDuration of infusionRecombinant urokinaseAcceptable success rateIntracerebral bleedPercutaneous revascularizationFinal angiogramGraft occlusionRecanalization rateAngiographic analysisHuman kidney cellsAllergic reactionsLow dose
1998
Procedural Results and Late Clinical Outcomes After Placement of Three or More Stents in Single Coronary Lesions
Kornowski R, Mehran R, Hong M, Satler L, Pichard A, Kent K, Mintz G, Waksman R, Laird J, Lansky A, Bucher T, Popma J, Leon M. Procedural Results and Late Clinical Outcomes After Placement of Three or More Stents in Single Coronary Lesions. Circulation 1998, 97: 1355-1361. PMID: 9577946, DOI: 10.1161/01.cir.97.14.1355.Peer-Reviewed Original ResearchConceptsNon-Q-wave MIUnfavorable lesion characteristicsClinical outcomesProcedural successMajor complicationsLesion characteristicsMultiple stentsOverall cardiac event-free survivalMajor cardiac event rateCardiac event-free survivalLong-term clinical outcomesCardiac event rateHospital procedural successLate clinical outcomesSingle coronary lesionsEvent-free survivalSaphenous vein graftsOverall procedural successRight coronary arteryLong-term complicationsQ-wave MILesion revascularizationConsecutive patientsCoronary lesionsLong dissection