2024
Clinical Significance of Diffusion-Weighted Brain MRI Lesions After TAVR Results of a Patient-Level Pooled Analysis
Lansky A, Grubman D, Dwyer M, Zivadinov R, Parise H, Moses J, Shah T, Pietras C, Tirziu D, Gambone L, Leon M, Nazif T, Messé S. Clinical Significance of Diffusion-Weighted Brain MRI Lesions After TAVR Results of a Patient-Level Pooled Analysis. Journal Of The American College Of Cardiology 2024, 84: 712-722. PMID: 39142725, DOI: 10.1016/j.jacc.2024.05.055.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementClinical ischemic strokeAcute brain infarctionDW-MRIReceiver operating characteristicIschemic strokeTranscatheter aortic valve replacement resultBrain infarctionPatient-level pooled analysisC-statisticBrain MRI lesionsAcute ischemic brain injuryDiffusion-weighted magnetic resonance imagingAortic valve replacementIndividual lesion volumesCore laboratory analysisIschemic brain injuryPredicting ischemic strokeMagnetic resonance imagingStroke Prevention TrialMRI lesionsValve replacementDW-MRI acquisitionsPatient-level dataPooled analysisTreatment of Acute Myocardial Infarction and Cardiogenic Shock: Outcomes of the RECOVER III Postapproval Study by Society of Cardiovascular Angiography and Interventions Shock Stage
Hanson I, Rusia A, Palomo A, Tawney A, Pow T, Dixon S, Meraj P, Sievers E, Johnson M, Wohns D, Ali O, Kapur N, Grines C, Burkhoff D, Anderson M, Lansky A, Naidu S, Basir M, O'Neill W. Treatment of Acute Myocardial Infarction and Cardiogenic Shock: Outcomes of the RECOVER III Postapproval Study by Society of Cardiovascular Angiography and Interventions Shock Stage. Journal Of The American Heart Association 2024, 13: e031803. PMID: 38293995, PMCID: PMC11056148, DOI: 10.1161/jaha.123.031803.Peer-Reviewed Original ResearchMeSH KeywordsAngiographyHeart-Assist DevicesHumansMyocardial InfarctionPercutaneous Coronary InterventionProspective StudiesShock, CardiogenicTreatment OutcomeConceptsSociety for Cardiovascular AngiographyCardiovascular AngiographyAcute myocardial infarctionIII studiesCardiogenic shockStage CPercutaneous coronary interventionMyocardial infarctionPostapproval studiesCoronary interventionImpella supportKaplan-Meier survival curve analysisSociety of Cardiovascular AngiographyThirty-day survivalResponse to therapyCohort of patientsStudy of patientsPredictors of mortalitySurvival curve analysisTreatment of acute myocardial infarctionPredictive of mortalitySeverity of shockSingle-armThirty-dayStaging system
2023
Targeted therapy with a localised abluminal groove, low-dose sirolimus-eluting, biodegradable-polymer coronary stent - five-year results of the TARGET All Comers randomised clinical trial.
Lansky A, Xu B, Baumbach A, Kelbæk H, van Royen N, Zheng M, Knaapen P, Slagboom T, Johnson T, Vlachojannis G, Arkenbout K, Holmvang L, Janssens L, Brugaletta S, Naber C, Schmitz T, Anderson R, Rittger H, Berti S, Barbato E, Toth G, Maillard L, Valina C, Buszman P, Thiele H, Schächinger V, Wijns W. Targeted therapy with a localised abluminal groove, low-dose sirolimus-eluting, biodegradable-polymer coronary stent - five-year results of the TARGET All Comers randomised clinical trial. EuroIntervention 2023, 19: e844-e855. PMID: 37860860, PMCID: PMC10687649, DOI: 10.4244/eij-d-23-00409.Peer-Reviewed Original ResearchConceptsTarget lesion failureDP-EES groupPercutaneous coronary interventionBP-SES groupBP-SESPrimary endpointDP-EESRate of TLFBiodegradable polymer sirolimus-eluting stentsST-elevation myocardial infarction (STEMI) presentationMyocardial infarction presentationSirolimus-eluting stentsFive-year resultsLong-term safetyAbluminal grooveLesion failureSecondary endpointsComers populationCoronary interventionMyocardial ischaemiaStent implantationClinical trialsTargeted therapyLandmark analysisStudy outcomesPredictors of Cerebral Embolic Debris During Transcatheter Aortic Valve Replacement: The SafePass 2 First-in-Human Study
Grubman D, Ahmad Y, Leipsic J, Blanke P, Pasupati S, Webster M, Nazif T, Parise H, Lansky A. Predictors of Cerebral Embolic Debris During Transcatheter Aortic Valve Replacement: The SafePass 2 First-in-Human Study. The American Journal Of Cardiology 2023, 207: 28-34. PMID: 37722198, DOI: 10.1016/j.amjcard.2023.08.137.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementAortic valve replacementValve replacementAtrial fibrillationHuman studiesEmbolic protection device useHigh embolic riskPrimary end pointHigh-risk patientsIndependent core laboratorySelf-expanding valvesComputed tomography angiographyProtection device useCerebral embolizationCerebrovascular eventsEmbolic riskAcute thrombusEmbolic burdenAngiography featuresTechnical successTomography angiographyEmbolic debrisValve useCore laboratoryEnd pointSex Differences in pLVAD-Assisted High-Risk Percutaneous Coronary Intervention Insights From the PROTECT III Study
Shah T, Abu-Much A, Batchelor W, Grines C, Baron S, Zhou Z, Li Y, Maini A, Redfors B, Hussain Y, Wollmuth J, Basir M, O'Neill W, Lansky A. Sex Differences in pLVAD-Assisted High-Risk Percutaneous Coronary Intervention Insights From the PROTECT III Study. JACC Cardiovascular Interventions 2023, 16: 1721-1729. PMID: 37409991, DOI: 10.1016/j.jcin.2023.04.036.Peer-Reviewed Original ResearchConceptsHigh-risk percutaneous coronary interventionFemale patientsIII studySex-based differencesImmediate PCISYNTAX scoreClinical outcomesMyocardial infarctionStroke/transient ischemic attackWorse renal functionAcute limb ischemiaTransient ischemic attackSex differencesPercutaneous coronary interventionAcute myocardial infarctionHigher ejection fractionCause deathCoronary complicationsIschemic attackMajor bleedingNonfemoral accessPercutaneous CoronaryPrior strokeCerebrovascular eventsVascular complicationsProspective, randomized, multicenter clinical study comparing a self-expanding covered stent to percutaneous transluminal angioplasty for treatment of upper extremity hemodialysis arteriovenous fistula stenosis
Dolmatch B, Cabrera T, Pergola P, Balamuthusamy S, Makris A, Cooper R, Moore E, Licht J, Macaulay E, Maleux G, Pfammatter T, Settlage R, Cristea E, Lansky A, Investigators A, Dolmatch B, Goh G, Hawkins S, Macaulay E, Spark I, de Graff R, Deutschmann H, Kickuth R, Maleux G, Pfammatter T, Kirksey L, Mendes R, Aruny J, Ali V, Cabrera T, Pergola P, Sharma D, Moore E, Shah H, Dwyer A, Yee D, Teng W, Cooper R, Balamuthusamy S, Lipkowitz G, Saad T, Licht J, Makris A, Rogers T, Burgess J, Hoggard J. Prospective, randomized, multicenter clinical study comparing a self-expanding covered stent to percutaneous transluminal angioplasty for treatment of upper extremity hemodialysis arteriovenous fistula stenosis. Kidney International 2023, 104: 189-200. PMID: 36990214, DOI: 10.1016/j.kint.2023.03.015.Peer-Reviewed Original ResearchConceptsTarget lesion primary patencyAccess circuit primary patencyPercutaneous transluminal angioplastyTarget lesion reinterventionPrimary patencyTransluminal angioplastyArteriovenous fistulaAVF stenosisAdditional clinical outcomesCircuit primary patencyCovered stent groupLesion primary patencyMulticenter clinical studyHemodialysis arteriovenous fistula stenosisArteriovenous fistula stenosisHemodialysis patientsPrimary outcomeRandomized studyClinical outcomesAVF dysfunctionStent groupClinical studiesFistula stenosisSix monthsPatients
2022
Self-expanding Transcatheter vs Surgical Aortic Valve Replacement in Intermediate-Risk Patients
Van Mieghem N, Deeb G, Søndergaard L, Grube E, Windecker S, Gada H, Mumtaz M, Olsen P, Heiser J, Merhi W, Kleiman N, Chetcuti S, Gleason T, Lee J, Cheng W, Makkar R, Crestanello J, George B, George I, Kodali S, Yakubov S, Serruys P, Lange R, Piazza N, Williams M, Oh J, Adams D, Li S, Reardon M, Gitter C, Meyer K, Roberts D, Bae R, Sorajja P, Sun B, Askew J, Eales F, Flavin T, Goessl M, Kshettry V, Mooney M, Pedersen W, Poulose A, Roohani P, Saeid Farivar R, Shronts R, Tarrel R, Young M, Butkus E, Pendleton K, Fry R, Heine C, La Roe K, Tran T, Weig L, Agarwal H, Langdon T, Satpathy R, Batter J, Bremer K, Indukuri U, Baas M, Oomes-Sistermans C, Smits M, Coenen C, Driesen I, Lauryssen L, Poorter M, Schaap J, Bentala M, den Heijer P, Pieter J, Remmers M, Story M, van Erven P, Verbiest H, Vos J, Bennett M, Dunaj W, Seaton D, Waller D, Khandheria B, Bajwa T, O'Hair D, Ahmed A, Allaqaband S, Gheith A, Marriott E, Qhavi A, Saxena V, Shhadeh A, Werner P, Yeomans C, Bessette L, Byrne J, Kieckhefer H, Munoz M, Russo E, Klein J, Morgan M, Byrne T, Caskey M, Amabile O, Brady K, Chung S, Dacanay K, Fang H, Franz D, Kelly C, Loli A, Payne J, Pershad A, Wang N, Lott J, Pool-Owens C, Porter C, Hennan J, Garrett H, Paulus B, Craig J, Elijovich L, Samaha J, Wolf B, Wright L, Zoghbi G, Willcott L, Roberts B, Hebeler R, Stoler R, Graybeal D, Grayburn P, Henry C, Mir O, Vallabhan R, Fanous M, Kaufman J, Chang J, Manning W, Riley M, Khabbaz K, Laham R, Popma J, Burke D, Caplan L, Chui S, Guibone K, Kumar S, Lioutas V, Liu D, Nathan S, Pinto D, Searls D, Fisher S, Guirgues L, Henderson S, Loving L, McWalters N, Patterson K, Burkart J, Carcedo B, Stacey R, Bladergroen M, Lim D, Edmonson S, Epps S, Katz M, Ng K, Sangha A, Aucoin J, Roberts M, Aubin J, Hotard C, Tassin M, Fail P, Feinberg E, Netherland D, Abben R, Allam M, Bates M, Dearman R, Gervais D, Haight E, Metes M, Naquin J, Tedesco V, Thibodeaux L, Thompson K, Aberle S, Amaro D, Grey W, Rose G, Scherer M, Rinaldi M, Skipper E, Bridges C, Downey W, Iyengar P, Martin J, Ryan L, Stiegel R, Story J, Alsabaawi K, Gheorghiu M, Singh C, Yashar J, Siegel R, Cheng W, Makkar R, Altman K, Jilaihawi H, Kar S, Khouw S, Mody C, Ramzy D, Salseth T, Stegic J, Trento A, Lazarte R, Sohn J, Hahn R, Khalique O, George I, Kodali S, Williams M, Gonzalez Castellon M, Gutierrez Contreras J, Kitago T, Kummer B, Lekic T, Miller E, Naka Y, Nazif T, Qureshi A, Rostanski S, Smith C, Willey J, Yaghi S, Abreu L, Clement E, Sabir S, Aji J, Bowen F, Kaddissi G, Mirsen T, Muntazar M, Ogbara J, Rosenbloom M, Schell W, Then R, Carl H, Huang H, Kreydi G, Wolak H, Sandidge G, Ali O, Asfaw Z, Henry S, Kafi A, Schreiber T, Andaya L, Baciewicz F, Bassett J, Choksi N, Kassas S, Munir A, Kothmeier F, Stroh A, Goppel G, Hettich I, Bleiziffer S, Hengstenberg C, Opitz A, Ruge H, Badiu C, Brenner S, Ehlmidi Y, Herold U, Kasel A, Kreuzpointner R, Lange R, Mazzitelli D, Poppert H, Seifert C, Vincze D, Voss B, Camuglia K, Cowhig D, Newbold S, Pierce C, Wootton S, Vemulapalli S, Velazquez E, Harrison J, Hughes G, Ali Y, Babi A, Banks A, Gaca J, Glower D, Gokhale S, Halim S, Hendry R, Hernandez C, Kiefer T, Klein M, Kolls B, Marrotte E, Pineda Maldonado A, Price A, Sherwood M, Swisher C, Van Wyck D, Vavalle J, Vora A, Wang A, Zeylikman Y, Amber K, Barnitt A, Lamm J, Mandelstam L, Schroeder R, Sumner R, Nair D, De A, Gaudiani V, Joye J, Brown L, Hessler C, Rammohan C, Vial C, Charles E, DeQuesada A, Kaner M, Mathewson S, Pitts K, Wheeler L, Wilson A, Davidson E, Frohwein S, Lerakis S, Merlino J, Sullivan A, Babaliaros V, Guyton R, Thourani V, Anderson A, Belagaje S, Benameur K, Devireddy C, Greene J, Harrison A, Hudson K, Leshnower B, Lieppe W, Macheers S, Mavromatis K, Miller J, Nahab F, Sanders K, Sarin E, Stewart J, Winkel D, Duininck L, Gussinklo T, Jadoenath-Oedai S, Ruiter A, van den Berg N, van der Velden-Macauley L, van Huis M, Verelst S, Geleijnse M, Vletter W, Bekker M, Kappetein A, Van Mieghem N, Bekkers J, Biesheuvel K, Birim O, Bol Raap G, Daemen J, de Jaegere P, de Lind van Wijngaarden R, Khajeh L, Kik C, Koudstaal P, Oei F, Scheele M, van de Woestijne P, van Geuns R, van Leeuwen W, Henderson A, Straight F, Schneider D, Tischler M, Dauerman H, Ittleman F, Schmoker J, Abernethy A, Alkhalil I, Azarbal A, Chava S, Commichau C, Coyle D, Denkmann J, Destephan C, Ehle G, El-Haddad M, Falduto C, Gorman M, Kadavath S, Leavitt B, Mack A, Malasana G, Moossavi S, Phuong N, Rambod M, Seecheran N, Sharma A, Terrien E, Worgan B, Zeglin-Sawczuk M, Burgess B, Killbride S, Temple A, Burnside J, Good C, Agarwal S, Casale A, Skelding K, Carter R, Cummings C, Grana V, Haegerl C, Harjai K, Holland N, Singh D, Stahl R, Stella J, Stewart B, Long D, Wood K, Alexander D, Barton S, Logtens E, Marsh A, McAdam J, Kovac J, Mariscalco G, Spyt T, Garimella S, Szostek J, Zlocha V, Kirkland L, Reid L, Reilly S, Menderhall M, Martin W, Park S, Seshiah P, Smith J, Gersch K, Hiratzka L, Kachoris J, Okum E, Cardozo M, Cyr G, Duvall W, Flynn A, Krupowies N, Parker M, Hagberg R, McKay R, Azemi T, Brown R, Fusco D, Hammond J, Hosley C, Kiernan F, Margey R, Preissler P, Sadiq I, Silverman I, Taboada S, Underhill D, Escobar J, Lopez B, Mullin S, Quesada C, Lawrence T, Naqvi T, Matthews R, Starnes V, Clavijo L, Cunningham M, Kim-Tenser M, Sanossian N, Shavelle D, DelMotte D, Henry S, Moltrassie J, Solanki A, Cooper R, Lee J, Parikh S, Wang D, Zweig B, O'Neill W, Paone G, Borgi J, Brewer R, Eng M, Greenbaum A, Guerrero M, Miller D, Mitsias P, Morgan J, Nemeh H, Alcaide Muñoz J, Medina Fernandez M, Carrasco Chinchilla F, Rodríguez Bailón I, Hernández García J, Such M, Alonso-Briales J, De La Cruz Cosme C, Dominguez-Franco A, Mataró López M, Melero J, Muñoz-Garcia A, Sanchez Espin G, Fernández Maese J, Torres M, Villa Suarez E, De La Hera J, Llosa Cortina J, Morís de la Tassa C, Avanzas Fernández P, Benavente Fernández L, Calleja S, Del Valle R, Morales Pérez C, Silva J, Bluntschli E, Keller D, Maritz S, Ruest R, Schönenberger C, Trovato M, Brugger N, Göber V, Kurmann R, Reineke S, Zürcher F, Carrel T, Windecker S, Arnold M, Balasubramaniam R, Bellwald S, Beyeler M, Broeg A, Bühlmann M, Büllesfeld L, Capek L, Chaloulos-Lakovidis P, Corpataux N, Englberger L, Gloekler S, Goldlin M, Huber C, Khattab A, Kurmann R, Lanz J, Liesirova K, Maamari B, Mattle H, Meinel T, Panos L, Praz F, Schönhoff F, Sleszak A, Spirito A, Stortecky S, Vaisnora L, Von Martial R, Wenaweser P, Zuk K, Musso I, Allen M, Gonzales M, Horton K, Doty J, Whisenant B, Caine W, Clayson S, Harkness J, Hoesch R, Huan M, Jones K, Miner E, Reid B, Sunderman E, Citro K, Fisher M, Willhide J, Corretti M, Conte J, Mandal K, Resar J, Chacko M, Hasan R, Heil B, Marsh E, Price J, Sciortino C, Shah A, Tolentino J, Bui A, Lee M, Watanabe C, Aharonian V, Moore N, Pfeffer T, Ajani Z, Mansukhani P, Sangha N, Yun K, Hylander S, Bäck M, Corbascio M, Hillebrant C, Rück A, De Palma R, Feldt K, Kostulas K, Settergren M, Yamasaki K, Anderson M, Bloomfield C, Burtonwood N, Harland C, Somers K, Ware T, Deakin S, Geldard S, Schlosshan D, Blackman D, Kaul P, Evans B, Javangula K, Limaye S, Malkin C, Wanklyn P, Farhi A, Manapat A, Maranan L, Mihelis E, Ng A, Ricketts M, Kronzon I, Perk G, Brinster D, Kliger C, Azhar S, Bonomo R, Dharva R, Fontana G, Mandel S, Mehla P, Patel N, Plestis K, Fox S, Mardell S, Novick T, Sandie K, de Jonge W, McLeod C, Mroz L, Weigand A, Chu M, Kiaii B, Teefy P, Bagur R, Debicki D, Diamantouros P, Gofton T, Mandzia J, McKenzie F, Mirsattari S, Valdis M, Young B, Klein W, Sawicki K, Dajani K, Darki A, Bakhos M, Leya F, Biller J, Lewis B, Morales-Vidal S, Schneck M, Schwartz J, Tuchek J, Biddle A, Ernst D, Haubenschild J, Howe-Clayton D, Johnson R, Mundt P, Reiter J, Bruce C, Freeman W, Kutzke K, Maalouf J, Nkomo V, Pislaru S, Sinak L, Pochettino A, Sandhu G, Alkhouli M, Best P, Bresnahan J, Eleid M, Fulgham J, Greason K, Gulati R, Holmes D, Maor E, Mathew V, Meissner I, Panaich S, Peterson A, Radford J, 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Radford N, Sookhoo V, Kyereme K, Punzalan R, Reynolds R, Sculeany B, Sharma R, Stuart A, Brecker S, Jahangiri M, Alassa A, Chandrasekaran V, Clarke B, Dowling C, Moynihan B, Roy D, Sarsam M, Bess R, Henkel M, Herbert N, Cohen G, Batra S, Davis T, Aboukasm A, Cullis P, LaLonde T, Martin J, Yamasaki H, Burkert M, Kingma B, Wheatley J, Segar D, Heimansohn D, Hermiller J, Ball M, Elsner G, Hanan S, Moainie S, Nukes T, Reibold P, Robison R, Salerno C, Sampson A, Walts P, Wandel E, Li M, Sarker S, Ahmed S, Fremes S, Radhakrishnan S, Arbel Y, Christakis G, Cohen G, Czarnecki A, Elbaz-Greener G, Feld Y, Hopyan J, Komatsu I, McCraig K, Shuvy M, Toma J, Vincenzo B, Wheeler C, Wijeysundera H, Wolff R, Beck P, Cabral D, DaCosta C, Hudson L, Pastie M, Abrahams N, Altamar I, Buitrago M, Cassman G, Leibovici Z, Nelson A, Recchia K, Robbins G, Studor K, Bethea B, Beyer E, Evans S, Goodis C, Malek A, Mueller-Kronast N, Pan H, Pantoja C, Ramos A, Wells C, Youngblood C, Snelus P, Gopal D, Jackson K, Brown D, Ryan W, Brinkman W, Gopal A, Harrington K, Mack M, Nosnik P, Potluri S, Smith R, Szerlip M, Blaylock C, Brinegar P, Canter L, Green L, Green L, Hazen P, Jacobs A, Khan S, Ludwig S, Mata M, Moore T, Underwood C, Faza N, Little S, Nagueh S, Kleiman N, Reardon M, Albright K, Atkins M, Barker C, Bledsoe D, Chiu D, Goel S, Gray T, Imperial-Aubin D, Lin C, Moye S, Ramchandani M, Ramlawi B, Reul R, Reyes M, Scheinin S, Volpi J, White S, Wyler von Ballmoos M, Blackburn B, Wong R, Hart C, Whitacker P, Lau J, Spies C, Badawi R, Graner S, Nakamura D, Plank B, Salem R, Seto T, Valenta D, Cruz A, Gallagher L, Schuck L, Siki M, Weeks A, Fishman L, Schwarz T, Bavaria J, Herrmann H, Anwaruddin S, Desai N, Giri J, Khella S, Li R, McGarvery M, Messe S, Price R, Quinn C, Szeto W, Vallabhajosyula P, Sun Y, Wu L, Tsang W, Thavendiranathan D, Feindel C, Horlick E, Casaubon L, Cusimano R, Del Campo M, Osten M, Silver F, Höwisch-Pengel R, Lechner G, Steiger B, Allgeier M, Jander N, Beyersdorf F, Neumann F, Büttner H, Comberg T, Diab N, Gick M, Günkel L, Pingpoh C, Rothe H, Siepe M, Thoma M, Winker T, Hager C, Sänger U, Stader M, Biaggi P, Gruner C, Stämpfli S, Binder R, Corti R, Falk V, Holy E, Maisano F, Grünenfelder J, Holubec T, Maier W, Nietlispach F, Wegener S, Atkinson R, Davis A, Hall S, Mangene S, Mazzurco S, Hoit B, Musarra R, Costa M, Markowitz A, Asi K, Attizzani G, Chuang D, Elgudin Y, Garcia C, Jadhav V, Le S, Miller B, Serkin Z, Shams T, Sila C, Simon D, Bezerra H, Deo S, Anderson J, Greening K, Karson J, Page S, Shawgo T, Freeman J, Mulhern K, Nath J, Tadros P, Zorn G, Hockstad E, Lechtenberg C, Muehlebach G, Rippee M, Rosterman L, Sundararajan J, Wang Y, Wiley M, Atapattu S, Marin y Kall C, Lowery M, de Marchena E, Salerno T, Alfonso C, Carillo R, Ferreira A, Panos A, Romano J, Williams D, Bhatt S, Migda E, Oakley J, Warshal W, Wilcock S, Booher A, LaBounty T, Chetcuti S, Deeb G, Adelman E, Boyle M, Geml R, Grossman P, Guerin D, Hodges K, Kim K, Lammers D, McDermott M, Menees D, Pace R, Patel H, Prager R, Ramchandren S, Romano M, Stamper A, Wang M, Zahuranec D, Ziarkiewicz M, Charlebois C, Chilton C, Labinaz M, Ruel M, Glover C, Lam K, Masters R, Steffenhagen N, Enlow-Germovsek M, Konopka K, McGargle R, Travis M, Anderson K, Cavalcante J, Crock F, Edelman K, Katz W, Gleason T, Lee J, Sultan I, Aghaebrahim A, Al-Bayai A, Bonaccorsi C, Campbell D, Giurgiutiu D, Gulati D, Hawkes C, Henry L, Jadhav A, Kenmuir C, Klein B, Kliner D, Limaye K, Nanduri S, Navid F, Patel P, Rangaraju S, Rocha M, Schindler J, Shoirah H, Streib C, Tadi P, Tememe D, Totoraitis R, Walker G, Ziayee H, Caufield L, Yeager C, Forbes J, Schwart K, Knight P, Ling F, Benesch C, Bogachan S, Hicks G, Kelly A, Narins C, Stuver T, Adams K, Blair-Anton L, Haynes M, Watts C, Baker M, Mendes L, Ball S, Goel K, Kaiser C, Robbins M, Zhao D, Ahmad R, Crenshaw M, Fredi J, Hermann L, Hoff S, Kirshner H, Levack M, Mittal S, O'Duffy A, Petracek M, Baer J, Liang G, Nguyen S, Heidenreich P, Nguyen P, Burdon T, Giacomini J, Yong C, Buchbinder M, Fann J, Kilgore S, Mitchell R, McDaniel S, Pack A, White W, Young T, Burgess P, Pu M, Upadhya B, Applegate R, Kon N, Arnan M, Baghshomali S, Bishop L, Bradbury E, Gandhi S, Kincaid E, Lefkowitz D, Lisle B, Batteria M, Rerisi E, Stepinowski K, Senicola T, Goncalves J, Schubach S, Schwartz R, Antaky K, Christiansen C, Marzo K, Michel K, Misra A, Varghese P, Wirkowski E, Levesque L, Sugeng L, Cleman M, Forrest J, Hashim S, Mangi A, Amin H, Darr U, Dewar M, Faheem O, Geirsson A, Greer D, Kaleel A, Kaple R, Lansky A, MacGrory B, Pfau S, Schindler J, Thompson C, Youn T, Yuh D, Yun J. Self-expanding Transcatheter vs Surgical Aortic Valve Replacement in Intermediate-Risk Patients. JAMA Cardiology 2022, 7: 1000-1008. PMID: 36001335, PMCID: PMC9403849, DOI: 10.1001/jamacardio.2022.2695.Peer-Reviewed Original ResearchMeSH KeywordsAgedAortic ValveAortic Valve StenosisFemaleHeart Valve ProsthesisHumansMaleProspective StudiesStrokeConceptsTranscatheter aortic valve replacementAortic valve replacementSevere aortic valve stenosisIntermediate-risk patientsAortic valve stenosisValve replacementAdverse eventsAortic stenosisValve stenosisParavalvular leakClinical trialsIndependent echocardiographic core laboratorySurgical aortic valve replacementSymptomatic severe aortic stenosisIndependent clinical events committeePrespecified secondary end pointsEchocardiographic core laboratoryIntermediate surgical riskIntermediate-risk subjectsLocal heart teamSecondary end pointsSerious adverse eventsSevere aortic stenosisSymptomatic aortic stenosisAortic valve areaLeft Ventricular Remodeling After Anterior-STEMI PCI: Imaging Observations in the Door-to-Unload (DTU) Pilot Trial.
O'Neill WW, Wang DD, Polak S, Moses JW, Josephy N, Koenig G, Kim RJ, Lansky A, Bellumkonda L, Douglas PS, Kapur NK. Left Ventricular Remodeling After Anterior-STEMI PCI: Imaging Observations in the Door-to-Unload (DTU) Pilot Trial. Journal Of Invasive Cardiology 2022, 34: e611-e619. PMID: 35830361, DOI: 10.25270/jic/21.00401.Peer-Reviewed Original ResearchConceptsCardiac magnetic resonanceLV ejection fractionInfarct sizeLeft ventricularLV unloadingEjection fractionPilot trialGroup 2Group 1ST-segment elevation myocardial infarction (STEMI) patientsImproved LV ejection fractionElevation myocardial infarction patientsLV end-diastolic volumeMajor cardiovascular outcomesPercutaneous coronary interventionMyocardial infarction patientsEnd-diastolic volumeEnd-systolic volumeAnterior STEMIEchocardiographic LVEFCardiogenic shockCardiovascular outcomesEchocardiographic parametersImmediate reperfusionCoronary interventionRandomized Trial of Chocolate Touch Compared With Lutonix Drug-Coated Balloon in Femoropopliteal Lesions (Chocolate Touch Study)
Shishehbor MH, Zeller T, Werner M, Brodmann M, Parise H, Holden A, Lichtenberg M, Parikh SA, Kashyap VS, Pietras C, Tirziu D, Ardakani S, Beschorner U, Krishnan P, Niazi KA, Wali AU, Lansky AJ. Randomized Trial of Chocolate Touch Compared With Lutonix Drug-Coated Balloon in Femoropopliteal Lesions (Chocolate Touch Study). Circulation 2022, 145: 1645-1654. PMID: 35377157, DOI: 10.1161/circulationaha.122.059646.Peer-Reviewed Original ResearchConceptsLutonix drug-coated balloonDrug-coated balloonsEnd pointPrimary efficacy end pointPrimary safety end pointIndependent clinical events committeeIschemic rest painPrimary efficacy rateEfficacy end pointPrimary end pointSafety end pointClinical events committeeMajor adverse eventsRate of restenosisDrug-Coated BalloonNoninferiority end pointSafety event rateAverage lesion lengthMajor amputationPopliteal diseaseRest painBailout stentingEfficacy ratePrimary patencyAdverse eventsImproved outcomes in patients with severely depressed LVEF undergoing percutaneous coronary intervention with contemporary practices
O'Neill WW, Anderson M, Burkhoff D, Grines CL, Kapur NK, Lansky AJ, Mannino S, McCabe JM, Alaswad K, Daggubati R, Wohns D, Meraj PM, Pinto DS, Popma JJ, Moses JW, Schreiber TL, Ohman E. Improved outcomes in patients with severely depressed LVEF undergoing percutaneous coronary intervention with contemporary practices. American Heart Journal 2022, 248: 139-149. PMID: 35192839, DOI: 10.1016/j.ahj.2022.02.006.Peer-Reviewed Original ResearchMeSH KeywordsCoronary Artery DiseaseHumansMyocardial InfarctionPercutaneous Coronary InterventionProspective StudiesTreatment OutcomeConceptsPercutaneous coronary interventionHigh-risk percutaneous coronary interventionPROTECT IIProTECT IIICoronary interventionDepressed LVEFIII studyIII patientsMyocardial infarctionStroke/transient ischemic attackTransient ischemic attackCompleteness of revascularizationPrior myocardial infarctionKaplan-Meier analysisDuration of supportHospital bleedingMACCE rateProcedural hypotensionCause mortalityCerebrovascular eventsIschemic attackJeopardy scorePrior CABGSYNTAX scoreHospital discharge
2021
Safety and efficacy of dedicated guidewire, microcatheter, and guide catheter extension technologies for chronic total coronary occlusion revascularization: Primary results of the Teleflex Chronic Total Occlusion Study
Kandzari DE, Alaswad K, Jaffer FA, Brilakis E, Croce K, Kearney K, Spaedy A, Yeh R, Thompson C, Nicholson W, Wyman RM, Riley R, Lansky A, Buller C, Karmpaliotis D. Safety and efficacy of dedicated guidewire, microcatheter, and guide catheter extension technologies for chronic total coronary occlusion revascularization: Primary results of the Teleflex Chronic Total Occlusion Study. Catheterization And Cardiovascular Interventions 2021, 99: 263-270. PMID: 34582080, DOI: 10.1002/ccd.29962.Peer-Reviewed Original ResearchConceptsMyocardial infarctionGuidewire recanalizationProcedural successCatheter extensionChronic total coronary occlusion revascularizationChronic total occlusion (CTO) percutaneous revascularizationFavorable procedural successGuide catheter extensionHigher lesion complexityHospital cardiac deathProspective registration studyTotal Occlusion StudyTarget lesion revascularizationPrevalence of diabetesPrior myocardial infarctionSingle-arm studyTIMI grade 2Femoral arterial accessJ-CTO scorePrevious bypass surgeryNon-CTO PCIHospital MACELesion revascularizationCTO revascularizationHemodynamic instabilityA randomized evaluation of the TriGuard™ HDH cerebral embolic protection device to Reduce the Impact of Cerebral Embolic LEsions after TransCatheter Aortic Valve ImplanTation: the REFLECT I trial
Lansky AJ, Makkar R, Nazif T, Messé S, Forrest J, Sharma R, Schofer J, Linke A, Brown D, Dhoble A, Horwitz P, Zang M, DeMarco F, Rajagopal V, Dwyer MG, Zivadinov R, Stella P, Rovin J, Parise H, Kodali S, Baumbach A, Moses J. A randomized evaluation of the TriGuard™ HDH cerebral embolic protection device to Reduce the Impact of Cerebral Embolic LEsions after TransCatheter Aortic Valve ImplanTation: the REFLECT I trial. European Heart Journal 2021, 42: 2670-2679. PMID: 34000004, DOI: 10.1093/eurheartj/ehab213.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementEfficacy endpointCerebral embolic protection devicesTranscatheter aortic valve implantationCentral nervous system injuryCerebral embolic lesionsCerebral ischemic lesionsHealth Stroke ScalePrimary efficacy endpointPrimary safety outcomeAortic valve replacementAortic valve implantationEmbolic protection devicesNervous system injuryDiffusion-weighted magnetic resonanceMontreal Cognitive AssessmentEffectiveness endpointCause mortalityCerebral protectionSafety endpointStroke ScaleValve implantationValve replacementI trialIschemic lesionsRandomized Evaluation of TriGuard 3 Cerebral Embolic Protection After Transcatheter Aortic Valve Replacement REFLECT II
Nazif TM, Moses J, Sharma R, Dhoble A, Rovin J, Brown D, Horwitz P, Makkar R, Stoler R, Forrest J, Messé S, Dickerman S, Brennan J, Zivadinov R, Dwyer MG, Lansky AJ, Investigators R. Randomized Evaluation of TriGuard 3 Cerebral Embolic Protection After Transcatheter Aortic Valve Replacement REFLECT II. JACC Cardiovascular Interventions 2021, 14: 515-527. PMID: 33663779, DOI: 10.1016/j.jcin.2020.11.011.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementAortic valve replacementSafety endpointValve replacementProcedure-related ischemic strokeCerebral embolic protectionComposite efficacy endpointPrimary safety endpointCerebral embolizationCerebral protectionEfficacy endpointII trialCerebral injuryIschemic strokeEmbolic protectionPatientsDrug AdministrationUS sitesU.S. FoodEndpointData reviewTrialsMulticenterEmbolizationInjury
2020
Safety and effectiveness of coronary intravascular lithotripsy in eccentric calcified coronary lesions: a patient-level pooled analysis from the Disrupt CAD I and CAD II Studies
Blachutzik F, Honton B, Escaned J, Hill JM, Werner N, Banning AP, Lansky AJ, Schlattner S, De Bruyne B, Di Mario C, Dörr O, Hamm C, Nef HM. Safety and effectiveness of coronary intravascular lithotripsy in eccentric calcified coronary lesions: a patient-level pooled analysis from the Disrupt CAD I and CAD II Studies. Clinical Research In Cardiology 2020, 110: 228-236. PMID: 32948882, PMCID: PMC7862504, DOI: 10.1007/s00392-020-01737-3.Peer-Reviewed Original ResearchConceptsCoronary intravascular lithotripsyIntravascular lithotripsyCalcified coronary lesionsII studyResidual stenosisCoronary lesionsCAD IPooled patient-level analysisFinal residual stenosisPercent residual stenosisFlow-limiting dissectionPatient-level analysisPatient-level dataHospital MACEIVL useAcute gainClinical outcomesConcentric lesionsEccentric lesionsCalcified lesionsAbrupt closureReflow eventsResultsClinical successStenosisConcentric stenosisIntravascular Lithotripsy for Treatment of Calcified Lower Extremity Arterial Stenosis: Initial Analysis of the Disrupt PAD III Study
Adams G, Shammas N, Mangalmurti S, Bernardo NL, Miller WE, Soukas PA, Parikh SA, Armstrong EJ, Tepe G, Lansky A, Gray WA. Intravascular Lithotripsy for Treatment of Calcified Lower Extremity Arterial Stenosis: Initial Analysis of the Disrupt PAD III Study. Journal Of Endovascular Therapy 2020, 27: 473-480. PMID: 32242768, PMCID: PMC7288854, DOI: 10.1177/1526602820914598.Peer-Reviewed Original ResearchConceptsPeripheral artery diseasePeripheral intravascular lithotripsyIntravascular lithotripsyResidual stenosisAcute gainObservational studyChronic limb-threatening ischemiaSingle-arm observational studyBalloon-based technologiesHigher acute gainMean residual stenosisLimb-threatening ischemiaLower limb arteriesEnd of procedureSevere arterial calcificationLow residual stenosisReal-world studyAngiographic complicationsDistal embolizationHospital dischargeIII studyArtery diseaseThrombotic eventsEndovascular treatmentLimb arteries
2019
Treating Post-Angioplasty Dissection in the Femoropopliteal Arteries Using the Tack Endovascular System 12-Month Results From the TOBA II Study
Gray WA, Cardenas JA, Brodmann M, Werner M, Bernardo NI, George JC, Lansky A. Treating Post-Angioplasty Dissection in the Femoropopliteal Arteries Using the Tack Endovascular System 12-Month Results From the TOBA II Study. JACC Cardiovascular Interventions 2019, 12: 2375-2384. PMID: 31806218, DOI: 10.1016/j.jcin.2019.08.005.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, BalloonBlood Vessel ProsthesisBlood Vessel Prosthesis ImplantationEuropeFemaleFemoral ArteryHumansMaleMiddle AgedPeripheral Arterial DiseasePopliteal ArteryProspective StudiesProsthesis DesignRisk FactorsStentsTime FactorsTreatment OutcomeUnited StatesVascular Access DevicesVascular PatencyVascular System InjuriesConceptsProximal popliteal arteryDrug-coated balloonsSuperficial femoral arteryPlain balloonPopliteal arteryFemoral arteryTack Endovascular SystemLong-term outcomesDCB angioplastyEfficacy endpointPrimary patencyResidual stenosisRestenotic lesionsMulticenter studyFemoropopliteal arteriesEndovascular SystemAngioplastyArteryClassification 2DissectionLesionsBalloonStenosisPatencyPatientsValidation of the all-comers design: Results of the TARGET-AC substudy
G Toth G, Lansky A, Baumbach A, Kelbæk H, van Royen N, Holmvang L, Janssens L, Brugaletta S, Barbato E, Maillard L, Kiemeneij F, Naber CK, Pucher F, Laursen PN, Ameloot K, Robles C, Milkas A, Sevilla J, Jensen C, Wijns W. Validation of the all-comers design: Results of the TARGET-AC substudy. American Heart Journal 2019, 221: 148-154. PMID: 31924299, DOI: 10.1016/j.ahj.2019.10.019.Peer-Reviewed Original ResearchConceptsComers designRisk factorsNon-ST elevation acute coronary syndromeElevation acute coronary syndromeNER groupReal-world clinical practiceGroup more patientsInternational multicentre registrySignificant valvular diseaseST-elevation infarctionAcute coronary syndromeChronic total occlusionWorld clinical practiceLow inclusion rateMulticentre registryThrombotic stenosisCoronary syndromePrimary PCIStable anginaAngiographic parametersComers populationPatient demographicsStable patientsStudy nursesMore patientsSafety and Effectiveness of Coronary Intravascular Lithotripsy for Treatment of Severely Calcified Coronary Stenoses
Ali ZA, Nef H, Escaned J, Werner N, Banning AP, Hill JM, De Bruyne B, Montorfano M, Lefevre T, Stone GW, Crowley A, Matsumura M, Maehara A, Lansky AJ, Fajadet J, Di Mario C. Safety and Effectiveness of Coronary Intravascular Lithotripsy for Treatment of Severely Calcified Coronary Stenoses. Circulation Cardiovascular Interventions 2019, 12: e008434. PMID: 31553205, DOI: 10.1161/circinterventions.119.008434.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCardiac CatheterizationCoronary AngiographyCoronary StenosisEuropeFemaleHumansLithotripsyMaleMiddle AgedPatient SafetyPercutaneous Coronary InterventionProspective StudiesRisk FactorsSeverity of Illness IndexStentsTime FactorsTomography, Optical CoherenceTreatment OutcomeUnited StatesVascular CalcificationConceptsSevere coronary artery calcificationCoronary artery calcificationMajor adverse cardiac eventsAdverse cardiac eventsPrimary end pointIntravascular lithotripsyOptical coherence tomographyCardiac eventsStent implantationPlaque fractureHospital major adverse cardiac eventsNon-Q-wave myocardial infarctionOptical coherence tomography substudyIndependent clinical events committeeCoherence tomographyDrug-eluting stent implantationEnd pointCoronary intravascular lithotripsyClinical events committeeHigh procedural successIndependent core laboratoryAcute luminal gainPost-approval studiesMechanism of actionCalcium fracture2-Year Clinical Outcomes of an Abluminal Groove–Filled Biodegradable-Polymer Sirolimus-Eluting Stent Compared With a Durable-Polymer Everolimus-Eluting Stent
Xu B, Saito Y, Baumbach A, Kelbæk H, van Royen N, Zheng M, Morel MA, Knaapen P, Slagboom T, Johnson TW, Vlachojannis G, Arkenbout KE, Holmvang L, Janssens L, Ochala A, Brugaletta S, Naber CK, Anderson R, Rittger H, Berti S, Barbato E, Toth GG, Maillard L, Valina C, Buszman P, Thiele H, Schächinger V, Lansky A, Wijns W, Investigators T. 2-Year Clinical Outcomes of an Abluminal Groove–Filled Biodegradable-Polymer Sirolimus-Eluting Stent Compared With a Durable-Polymer Everolimus-Eluting Stent. JACC Cardiovascular Interventions 2019, 12: 1679-1687. PMID: 31129092, DOI: 10.1016/j.jcin.2019.05.001.Peer-Reviewed Original ResearchMeSH KeywordsAbsorbable ImplantsAgedCardiovascular AgentsCoronary Artery DiseaseCoronary ThrombosisDrug-Eluting StentsDual Anti-Platelet TherapyEuropeEverolimusFemaleHumansMaleMiddle AgedPercutaneous Coronary InterventionPolymersProspective StudiesProsthesis DesignRisk FactorsSirolimusTime FactorsTreatment OutcomeConceptsTarget lesion failureXIENCE stentXience groupLesion failurePrimary endpointClinical outcomesIschemia-driven target lesion revascularizationTarget vessel myocardial infarctionProbable stent thrombosisTarget lesion revascularizationVessel myocardial infarctionLong-term outcomesDurable polymer everolimusBiodegradable Polymer SirolimusAbluminal grooveFIREHAWK stentLesion revascularizationCardiac deathComparable safetyStent thrombosisMyocardial infarctionClinical trialsEfficacy profileNoninferiority trialLandmark analysisBalloon-Expandable Vascular Covered Stent in the Treatment of Iliac Artery Occlusive Disease: 9-Month Results from the BOLSTER Multicenter Study
Laird JR, Zeller T, Holden A, Scheinert D, Moore E, Mendes R, Schmiedel R, Settlage R, Lansky A, Jaff MR, Investigators B, Elmasri F, Robinson W, Beasley R, Mego D, Marica S, Bersin R, Kujath S, Razavi M, Teßarek J, Schulte K. Balloon-Expandable Vascular Covered Stent in the Treatment of Iliac Artery Occlusive Disease: 9-Month Results from the BOLSTER Multicenter Study. Journal Of Vascular And Interventional Radiology 2019, 30: 836-844.e1. PMID: 30956077, DOI: 10.1016/j.jvir.2018.12.031.Peer-Reviewed Original ResearchConceptsMajor adverse eventsWalking Impairment QuestionnaireQuality of lifeLesion revascularizationPrimary patencyMyocardial infarctionIliac artery occlusive diseaseComposite endpoint rateProcedure-related deathsTarget lesion revascularizationArtery occlusive diseaseSingle-arm studyMajor amputationRutherford categoryOcclusive lesionsPrimary endpointSecondary endpointsAdverse eventsClinical improvementImpairment QuestionnaireOcclusive diseaseClinical outcomesMulticenter studyEndpoint rateIliac artery