2023
Sex Differences in pLVAD-Assisted High-Risk Percutaneous Coronary Intervention Insights From the PROTECT III Study
Shah T, Abu-Much A, Batchelor W, Grines C, Baron S, Zhou Z, Li Y, Maini A, Redfors B, Hussain Y, Wollmuth J, Basir M, O'Neill W, Lansky A. Sex Differences in pLVAD-Assisted High-Risk Percutaneous Coronary Intervention Insights From the PROTECT III Study. JACC Cardiovascular Interventions 2023, 16: 1721-1729. PMID: 37409991, DOI: 10.1016/j.jcin.2023.04.036.Peer-Reviewed Original ResearchConceptsHigh-risk percutaneous coronary interventionFemale patientsIII studySex-based differencesImmediate PCISYNTAX scoreClinical outcomesMyocardial infarctionStroke/transient ischemic attackWorse renal functionAcute limb ischemiaTransient ischemic attackSex differencesPercutaneous coronary interventionAcute myocardial infarctionHigher ejection fractionCause deathCoronary complicationsIschemic attackMajor bleedingNonfemoral accessPercutaneous CoronaryPrior strokeCerebrovascular eventsVascular complications
2022
Development and validation of an automated algorithm for end point adjudication for a large U.S. national registry
Friedman DJ, Pierre D, Wang Y, Gambone L, Koutras C, Segawa C, Farb A, Vemulapalli S, Varosy PD, Masoudi FA, Lansky A, Curtis JP, Freeman JV. Development and validation of an automated algorithm for end point adjudication for a large U.S. national registry. American Heart Journal 2022, 254: 102-111. PMID: 36007567, DOI: 10.1016/j.ahj.2022.08.006.Peer-Reviewed Original ResearchConceptsEnd point adjudicationCEC adjudicationEnd pointLarge registriesClinical trialsNational Cardiovascular Data RegistryMajor vascular complicationsU.S. National RegistryPost-discharge eventsAgreement rateMajor bleedingNeurologic eventsVascular complicationsNational registryEvent adjudicationData registryRegistryCommittee's evaluationsPercent agreementGold standardAgreement thresholdHospitalTrialsFurther confirmationBleedingMechanical Circulatory Support in Myocardial Infarction Complicated by Cardiogenic Shock: Impact of Sex and Timing
Shah T, Lansky A, Grines C, O'Neill W, Moses J, Chieffo A, Kapur N, Chou J. Mechanical Circulatory Support in Myocardial Infarction Complicated by Cardiogenic Shock: Impact of Sex and Timing. Journal Of The Society For Cardiovascular Angiography & Interventions 2022, 1: 100002. PMID: 39130134, PMCID: PMC11307664, DOI: 10.1016/j.jscai.2021.100002.Peer-Reviewed Original ResearchPercutaneous coronary interventionPLVAD supportCardiogenic shockMyocardial infarctionPercutaneous left ventricular assist device supportLower baseline mean arterial pressureBaseline mean arterial pressureLeft ventricular assist device supportVentricular assist device supportInotropes/vasopressorsMyocardial Infarction ComplicatedHospital adverse eventsMean arterial pressurePredictors of mortalityAccess-related complicationsMechanical circulatory supportAssist device supportSex-based outcomesAcute myocardial infarctionBackground Sex differencesImpact of sexImpella supportMajor bleedingHospital survivalVascular complications
2018
Primary outcomes and mechanism of action of intravascular lithotripsy in calcified, femoropopliteal lesions: Results of Disrupt PAD II
Brodmann M, Werner M, Holden A, Tepe G, Scheinert D, Schwindt A, Wolf F, Jaff M, Lansky A, Zeller T. Primary outcomes and mechanism of action of intravascular lithotripsy in calcified, femoropopliteal lesions: Results of Disrupt PAD II. Catheterization And Cardiovascular Interventions 2018, 93: 335-342. PMID: 30474206, DOI: 10.1002/ccd.27943.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overEuropeFemaleFemoral ArteryHumansLithotripsyMaleMiddle AgedNew ZealandPeripheral Arterial DiseasePopliteal ArteryProgression-Free SurvivalProspective StudiesRetreatmentRisk FactorsSeverity of Illness IndexTime FactorsUltrasonic TherapyVascular CalcificationVascular PatencyConceptsMajor adverse eventsIntravascular lithotripsyPrimary patencyDuplex ultrasonographyPAD IIAcute procedure successFinal residual stenosisPrimary effectiveness endpointPrimary safety endpointKey secondary endpointPeripheral arterial stenosisMulti-center studySonic pressure wavesMechanism of actionCompelling safetyEffectiveness endpointAnti-proliferative therapiesSafety endpointSecondary endpointsVascular complicationsAdverse eventsFemoropopliteal lesionsResidual stenosisPrimary outcomeAcute gain
2016
Transcatheter Aortic Valve Replacement in Women Versus Men (from the US CoreValve Trials)
Forrest JK, Adams DH, Popma JJ, Reardon MJ, Deeb GM, Yakubov SJ, Hermiller JB, Huang J, Skelding KA, Lansky A. Transcatheter Aortic Valve Replacement in Women Versus Men (from the US CoreValve Trials). The American Journal Of Cardiology 2016, 118: 396-402. PMID: 27346591, DOI: 10.1016/j.amjcard.2016.05.013.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic Valve StenosisCause of DeathComorbidityFemaleFrail ElderlyHumansIncidenceMaleMortalityPostoperative ComplicationsPostoperative HemorrhageSeverity of Illness IndexSex FactorsStrokeTranscatheter Aortic Valve ReplacementTreatment OutcomeVentricular Dysfunction, LeftConceptsTranscatheter aortic valve replacementAortic valve replacementCoreValve prosthesisValve replacementSevere symptomatic aortic stenosisSurgical aortic valve replacementLeft ventricular systolic functionWomen Versus MenMajor vascular complicationsSymptomatic aortic stenosisIncidence of strokeProcedure-related complicationsVentricular systolic functionCoronary artery diseaseLife-threatening bleedsSignificant baseline differencesGender-related differencesCause mortalityVascular complicationsBaseline characteristicsPatient characteristicsPrevious strokeSystolic functionAortic stenosisArtery disease
2004
Comparison of differences in outcome after percutaneous coronary intervention in men versus women <40 years of age
Lansky AJ, Mehran R, Dangas G, Cristea E, Shirai K, Costa R, Costantini C, Tsuchiya Y, Carlier S, Mintz G, Cottin Y, Stone G, Moses J, Leon MB. Comparison of differences in outcome after percutaneous coronary intervention in men versus women <40 years of age. The American Journal Of Cardiology 2004, 93: 916-919. PMID: 15050498, DOI: 10.1016/j.amjcard.2003.12.046.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionYears of ageCoronary interventionVascular complicationsMyocardial infarctionMortality rateAggressive risk factor modificationQ-wave myocardial infarctionHospital vascular complicationsMore diabetes mellitusPredominance of diabetesNonfatal myocardial infarctionRisk factor modificationPremature coronary diseaseRisk factor profileOnly independent predictorMultivariable regression analysisLess hyperlipidemiaIschemic complicationsConsecutive patientsCoronary diseaseDiabetes mellitusIndependent predictorsPremature atherosclerosisFactor modification
2001
Vascular complications after percutaneous coronary interventions following hemostasis with manual compression versus arteriotomy closure devices
Dangas G, Mehran R, Kokolis S, Feldman D, Satler L, Pichard A, Kent K, Lansky A, Stone G, Leon M. Vascular complications after percutaneous coronary interventions following hemostasis with manual compression versus arteriotomy closure devices. Journal Of The American College Of Cardiology 2001, 38: 638-641. PMID: 11527609, DOI: 10.1016/s0735-1097(01)01449-8.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionArteriotomy closure devicesManual compressionVascular complicationsCoronary interventionClosure deviceHigher vascular complication ratesVascular complication ratesVascular surgical repairPrevious clinical studiesAchievement of hemostasisHematocrit dropEarly ambulationComplication rateConsecutive patientsTransfemoral approachSheath removalSurgical repairArteriovenous fistulaHemostasis techniquesAccess siteClinical studiesLarge cohortMultivariate analysisComplicationsEffect of gender on the outcomes of contemporary percutaneous coronary intervention
Peterson E, Lansky A, Kramer J, Anstrom K, Lanzilotta M, Investigators F. Effect of gender on the outcomes of contemporary percutaneous coronary intervention. The American Journal Of Cardiology 2001, 88: 359-364. PMID: 11545754, DOI: 10.1016/s0002-9149(01)01679-4.Peer-Reviewed Original ResearchConceptsIndependent risk factorRisk factorsBaseline clinical risk factorsHigher vascular complication ratesContemporary percutaneous coronary interventionPercutaneous coronary intervention (PCI) technologyRisk adjustmentExtensive coronary diseaseProcedural mortality rateVascular complication ratesClinical risk factorsPercutaneous coronary interventionBody surface areaPatient body sizeHospital revascularizationAssociation of genderComorbid illnessesVascular complicationsComplication rateCoronary interventionCoronary diseaseProcedural outcomesFemale genderIndependent riskPCI casesInfluence of gender on early and one-year clinical outcomes after saphenous vein graft stenting
Ahmed J, Dangas G, Lansky A, Mehran R, Hong M, Mintz G, Pichard A, Satler L, Kent K, Stone G, Leon M. Influence of gender on early and one-year clinical outcomes after saphenous vein graft stenting. The American Journal Of Cardiology 2001, 87: 401-405. PMID: 11179522, DOI: 10.1016/s0002-9149(00)01391-6.Peer-Reviewed Original ResearchConceptsAcute renal failureClinical outcomesSVG lesionsHospital mortalityVascular complicationsRenal failureProcedural successStent implantationFemale genderOne-year clinical outcomesSaphenous vein graft stentingLate clinical outcomesOverall procedural successSaphenous vein graftsVentricular ejection fractionInfluence of genderMultivariate regression analysisGraft stentingLesion revascularizationCoronary revascularizationConsecutive patientsDiabetes mellitusEjection fractionHospital eventsVein grafts