2004
Favorable effect of γ‐radiation for in‐stent restenosis: Effect of diabetes on angiographic and clinical outcomes
Iakovou I, Mehran R, Dangas G, Lansky AJ, Stone GW, Mintz GS, Aymong E, Ashby DT, Pichard AD, Satler LF, Kent K, Leon MB, Waksman R. Favorable effect of γ‐radiation for in‐stent restenosis: Effect of diabetes on angiographic and clinical outcomes. Catheterization And Cardiovascular Interventions 2004, 62: 303-307. PMID: 15224295, DOI: 10.1002/ccd.20070.Peer-Reviewed Original ResearchConceptsTarget lesion revascularizationDiabetes mellitusStent restenosisMajor adverse cardiac event ratesAdverse cardiac event ratesIn-Stent Restenosis TrialLower target lesion revascularizationMajor adverse cardiac eventsNon-DM patientsAdverse cardiac eventsCardiac event rateTreatment of ISREffect of diabetesSimilar procedural successGamma radiation therapyLesion revascularizationHospital outcomesRestenosis TrialVessel revascularizationCardiac eventsProcedural successClinical outcomesWashington RadiationVascular brachytherapyPatients
2003
Comparison of the angiographic outcomes after beta versus gamma vascular brachytherapy for treatment of in-stent restenosis
Shirai K, Lansky AJ, Mintz GS, Costantini CO, Fahy M, Mehran R, Dangas G, Moses JW, Stone GW, Waksman R, Leon MB. Comparison of the angiographic outcomes after beta versus gamma vascular brachytherapy for treatment of in-stent restenosis. The American Journal Of Cardiology 2003, 92: 1409-1413. PMID: 14675575, DOI: 10.1016/j.amjcard.2003.08.047.Peer-Reviewed Original ResearchConceptsMinimum lumen diameterVascular brachytherapyLesion lengthSegment restenosisAngiographic outcomesStent restenosisFinal minimum lumen diameterRandomized clinical trialsIndependent angiographic predictorsAngiographic restenosisPlacebo groupAngiographic predictorsAngiographic resultsMultivariable analysisNative coronariesVessel sizeClinical trialsLesion complexityVBT groupRestenosisLumen diameterSimilar reductionPlaceboGreater reductionLesionsUsefulness of the angiographic pattern of in-stent restenosis in predicting the success of gamma vascular brachytherapy
Costantini CO, Lansky AJ, Mintz GS, Shirai K, Dangas G, Mehran R, Stone GW, Leon MB. Usefulness of the angiographic pattern of in-stent restenosis in predicting the success of gamma vascular brachytherapy. The American Journal Of Cardiology 2003, 92: 1214-1217. PMID: 14609602, DOI: 10.1016/j.amjcard.2003.07.036.Peer-Reviewed Original ResearchConceptsStent restenosisAngiographic patternsVascular brachytherapyMajor adverse cardiac event ratesAdverse cardiac event ratesBinary angiographic restenosis rateAngiographic restenosis rateCardiac event rateStent restenosis patternsRestenosis patternLesion revascularizationPrognostic roleRestenosis rateTotal occlusionClinical trialsProliferative patternEvent ratesRestenosisPooled data setBrachytherapyRevascularizationPatientsAngiogramsBaselineTrialsVascular brachytherapy using a beta emitter source in diabetic patients with in-stent restenosis: Angiographic and clinical outcomes
Suntharalingam M, Laskey WK, Tantibhedhyangkul W, Lansky A, Teirstein P, Bass T, Silber S, Rutherford B, Wilmer C, Popma JJ, Kuntz R, Bonan R. Vascular brachytherapy using a beta emitter source in diabetic patients with in-stent restenosis: Angiographic and clinical outcomes. International Journal Of Radiation Oncology • Biology • Physics 2003, 57: 536-542. PMID: 12957267, DOI: 10.1016/s0360-3016(03)00537-6.Peer-Reviewed Original ResearchConceptsVessel revascularization ratePercutaneous coronary interventionDiabetic patientsNondiabetic patientsVascular brachytherapyNondiabetic counterpartsStent restenosisRevascularization ratesCoronary interventionLess target lesion revascularizationConventional percutaneous coronary interventionBinary angiographic restenosisAngiographic restenosis rateTarget lesion revascularizationReference vessel diameterComplex coronary lesionsMinimal lumen diameterStudy of patientsPercent diameter stenosisVessel diameterTreatment effectsBeta-Cath SystemBreslow-Day testLesion revascularizationAngiographic restenosisIntravascular brachytherapy for native coronary ostial in-stent restenotic lesions
Costantini CO, Lansky AJ, Mintz GS, Shirai K, Dangas G, Mehran R, Fahy M, Slack S, Coral M, Teirstein PS, Waksman R, Stone G, Moses J, Leon MB. Intravascular brachytherapy for native coronary ostial in-stent restenotic lesions. Journal Of The American College Of Cardiology 2003, 41: 1725-1731. PMID: 12767655, DOI: 10.1016/s0735-1097(03)00298-5.Peer-Reviewed Original ResearchConceptsAorto-ostial lesionsVascular brachytherapyRecurrence rateOstial ISRRestenosis rateStent restenosisBaseline lesion lengthStent restenotic lesionsHigh recurrence rateBinary restenosisPercutaneous reinterventionPlacebo patientsISR lesionsRestenotic lesionsQuantitative angiographyBeta patientsPatientsPooled databaseConventional treatmentRestenosisPlaceboLesionsLesion lengthBrachytherapySimilar reduction
2002
Predictors of radiation failure after treatment of in-stent restenosis with gamma vascular brachytherapy: pooled analysis from GAMMA I, II, and SCRIPPS III studies
Limpijankit T, Abizaid A, Mehran R, Lansky A, Dangas G, Kipshidze N, Stone G, Collins M, Moses J, Leon M, Teirstein P. Predictors of radiation failure after treatment of in-stent restenosis with gamma vascular brachytherapy: pooled analysis from GAMMA I, II, and SCRIPPS III studies. Journal Of The American College Of Cardiology 2002, 39: 46. DOI: 10.1016/s0735-1097(02)80196-6.Peer-Reviewed Original ResearchIs bigger better with vascular brachytherapy (VBT) for in-stent restenosis? Impact of optimal final angiographic results and predictors of restenosis in 990 VBT patients
Costantini C, Lansky A, Mehran R, Desai K, Proctor B, Shirai K, Dave N, Cristea E, Fahy M, Dangas G, Stone G, Waksman R, Moses J, Leon M. Is bigger better with vascular brachytherapy (VBT) for in-stent restenosis? Impact of optimal final angiographic results and predictors of restenosis in 990 VBT patients. Journal Of The American College Of Cardiology 2002, 39: 20. DOI: 10.1016/s0735-1097(02)80087-0.Peer-Reviewed Original ResearchDoes vessel size have an impact on recurence rates following gamma vascular brachytherapy: acute and nine-month results from SCRIPPS III registry
Adamian M, Mehran R, Dangas G, New G, Abizaid A, Lansky A, Weisz G, Grise M, Collins M, Kreps E, Stone G, Moussa I, Moses J, Leon M, Teirstein P. Does vessel size have an impact on recurence rates following gamma vascular brachytherapy: acute and nine-month results from SCRIPPS III registry. Journal Of The American College Of Cardiology 2002, 39: 64. DOI: 10.1016/s0735-1097(02)80277-7.Peer-Reviewed Original ResearchGamma vascular brachytherapy neutralizes the negative impact of diabetes mellitus on clinical outcomes after PCI for in-stent restenosis: pooled data from Gamma I, Gamma II, and SCRIPPS III trials
Adamian M, Moussa I, Mehran R, Dangas G, Lansky A, Mintz G, Moussavian M, Abizaid A, Adamyan Y, Mohamed M, Kuntz R, Stone G, Moses J, Leon M, Tierstein P. Gamma vascular brachytherapy neutralizes the negative impact of diabetes mellitus on clinical outcomes after PCI for in-stent restenosis: pooled data from Gamma I, Gamma II, and SCRIPPS III trials. Journal Of The American College Of Cardiology 2002, 39: 64. DOI: 10.1016/s0735-1097(02)80276-5.Peer-Reviewed Original ResearchUse of localised intracoronary β radiation in treatment of in-stent restenosis: the INHIBIT randomised controlled trial
Waksman R, Raizner AE, Yeung AC, Lansky AJ, Vandertie L, investigators I. Use of localised intracoronary β radiation in treatment of in-stent restenosis: the INHIBIT randomised controlled trial. The Lancet 2002, 359: 551-557. PMID: 11867107, DOI: 10.1016/s0140-6736(02)07741-3.Peer-Reviewed Original ResearchConceptsBinary angiographic restenosis ratePrimary safety endpointAngiographic restenosis rateTarget lesion revascularisationStent restenosisPlacebo groupSafety endpointRestenosis rateRadiated groupMyocardial infarctionMajor adverse cardiac eventsIntracoronary beta radiationIntracoronary β-radiationSuccessful coronary interventionAdverse cardiac eventsPrimary efficacy endpointRecurrence of restenosisBeta-radiation treatmentEfficacy endpointAngiographic outcomesCardiac eventsCoronary interventionIntracoronary stentingProcedural successVascular brachytherapyQuantitative angiographic methods for appropriate end-point analysis, edge-effect evaluation, and prediction of recurrent restenosis after coronary brachytherapy with gamma irradiation
Lansky AJ, Dangas G, Mehran R, Desai KJ, Stone G, Leon M, Mintz G, Waksman R, Wu H, Fahy M. Quantitative angiographic methods for appropriate end-point analysis, edge-effect evaluation, and prediction of recurrent restenosis after coronary brachytherapy with gamma irradiation. Journal Of The American College Of Cardiology 2002, 39: 274-280. PMID: 11788219, DOI: 10.1016/s0735-1097(01)01745-4.Peer-Reviewed Original ResearchConceptsTarget vessel revascularizationRecurrent restenosisDiameter stenosisReceiver operator curveStent restenosisIn-Stent Restenosis TrialIntracoronary radiation therapyPercent diameter stenosisQuantitative coronary angiographyQuantitative angiographic methodsAngiographic locationBlinded therapyRestenosis TrialVessel revascularizationClinical restenosisCoronary angiographyRestenosis rateRestenotic lesionsTreatment failureWashington RadiationBrachytherapy trialsInterventional treatmentVascular brachytherapyEnd-point analysisRadiation therapy