2024
Cerebrovascular Events in Patients Undergoing Transcatheter Aortic Valve Replacement: A Review.
Patel K, Rathod K, Lansky A, Prendergast B, Kharbanda R, Mathur A, Perry R, Baumbach A. Cerebrovascular Events in Patients Undergoing Transcatheter Aortic Valve Replacement: A Review. Stroke 2024 PMID: 39371005, DOI: 10.1161/strokeaha.124.047149.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementAortic valve replacementCerebrovascular eventsValve replacementAtrial fibrillationLow operative risk patientsAdvent of transcatheter aortic valve replacementNew-onset atrial fibrillationComplication of transcatheter aortic valve replacementIncreased risk of bleedingHigher risk of cerebrovascular eventsAssociated with significant mortalityTranscatheter aortic valve replacement procedureRisk of cerebrovascular eventsOperative risk patientsResults of embolizationRisk of bleedingRisk of thromboembolismHypoattenuated leaflet thickeningImprove risk stratificationCerebral lesion volumeAssociated with cerebrovascular eventsTherapy to patientsOverall stroke rateSeverity of comorbiditiesClinical Significance of Diffusion-Weighted Brain MRI Lesions After TAVR Results of a Patient-Level Pooled Analysis
Lansky A, Grubman D, Dwyer M, Zivadinov R, Parise H, Moses J, Shah T, Pietras C, Tirziu D, Gambone L, Leon M, Nazif T, Messé S. Clinical Significance of Diffusion-Weighted Brain MRI Lesions After TAVR Results of a Patient-Level Pooled Analysis. Journal Of The American College Of Cardiology 2024, 84: 712-722. PMID: 39142725, DOI: 10.1016/j.jacc.2024.05.055.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementClinical ischemic strokeAcute brain infarctionDW-MRIReceiver operating characteristicIschemic strokeTranscatheter aortic valve replacement resultBrain infarctionPatient-level pooled analysisC-statisticBrain MRI lesionsAcute ischemic brain injuryDiffusion-weighted magnetic resonance imagingAortic valve replacementIndividual lesion volumesCore laboratory analysisIschemic brain injuryPredicting ischemic strokeMagnetic resonance imagingStroke Prevention TrialMRI lesionsValve replacementDW-MRI acquisitionsPatient-level dataPooled analysisLong-Term Outcomes of Transcatheter vs Surgical Aortic Valve Replacement: Meta-analysis of Randomized Trials
Talanas G, Laconi A, Kereiakes D, Merella P, Reardon M, Spano A, Petretto G, Lauriola F, Casula M, Micheluzzi V, Isgender M, Chatzizisis Y, Farkouh M, Lansky A, Piazza N, Portoghese M, Casu G, Navarese E. Long-Term Outcomes of Transcatheter vs Surgical Aortic Valve Replacement: Meta-analysis of Randomized Trials. Journal Of The Society For Cardiovascular Angiography & Interventions 2024, 3: 102143. PMID: 39131994, PMCID: PMC11307397, DOI: 10.1016/j.jscai.2024.102143.Peer-Reviewed Original ResearchSurgical aortic valve replacementTranscatheter aortic valve replacementAortic valve replacementLong-term outcomesMeta-analysis of randomized trialsSevere aortic stenosisValve replacementValve thrombosisPacemaker implantationValve gradientAortic stenosisParavalvular leakFollow-upStroke riskRandomized trialsLong-term outcomes of patientsBalloon-expandable transcatheter aortic valve replacementSelf-expanding transcatheter aortic valve replacementSafety of transcatheter aortic valve replacementRisk of transcatheter aortic valve replacementRisk of pacemaker implantationSecondary end pointsSurgical risk profileOutcomes of patientsMeta-analysis
2023
Predictors of Cerebral Embolic Debris During Transcatheter Aortic Valve Replacement: The SafePass 2 First-in-Human Study
Grubman D, Ahmad Y, Leipsic J, Blanke P, Pasupati S, Webster M, Nazif T, Parise H, Lansky A. Predictors of Cerebral Embolic Debris During Transcatheter Aortic Valve Replacement: The SafePass 2 First-in-Human Study. The American Journal Of Cardiology 2023, 207: 28-34. PMID: 37722198, DOI: 10.1016/j.amjcard.2023.08.137.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementAortic valve replacementValve replacementAtrial fibrillationHuman studiesEmbolic protection device useHigh embolic riskPrimary end pointHigh-risk patientsIndependent core laboratorySelf-expanding valvesComputed tomography angiographyProtection device useCerebral embolizationCerebrovascular eventsEmbolic riskAcute thrombusEmbolic burdenAngiography featuresTechnical successTomography angiographyEmbolic debrisValve useCore laboratoryEnd pointCerebral embolic protection during transcatheter heart interventions.
Jimenez Diaz V, Kapadia S, Linke A, Mylotte D, Lansky A, Grube E, Settergren M, Puri R. Cerebral embolic protection during transcatheter heart interventions. EuroIntervention 2023, 19: 549-570. PMID: 37720969, PMCID: PMC10495748, DOI: 10.4244/eij-d-23-00166.Peer-Reviewed Original ResearchConceptsCerebral embolic protection devicesTranscatheter aortic valve replacementNew cerebral lesionsMajority of patientsCerebral lesionsTransfemoral transcatheter aortic valve replacementHeart interventionsCerebral embolic protectionAortic valve replacementEmbolic protection devicesBrain imaging studiesPrimary endpointDevastating complicationPeriprocedural strokeValve replacementEmbolic protectionEmbolic showerApparent strokeCerebral embolisationTranscatheter proceduresSpecific trialsImaging studiesStrokePatientsLesionsEffect of antecedent statin usage on conduction disturbances and arrhythmias after transcatheter aortic valve replacement
Shah T, Maarek R, See C, Huang H, Wang Y, Parise H, Forrest J, Lansky A. Effect of antecedent statin usage on conduction disturbances and arrhythmias after transcatheter aortic valve replacement. Cardiovascular Revascularization Medicine 2023, 59: 3-8. PMID: 37573173, DOI: 10.1016/j.carrev.2023.07.022.Peer-Reviewed Original ResearchConceptsAtrial fibrillationConduction disturbancesPrimary endpointStatin usersPacemaker placementRate of AFTranscatheter aortic valve replacementNew atrial fibrillationNew conduction disturbancesPersistent conduction disturbancesAortic valve replacementLong-term prognosisSmall retrospective studiesSignificant differencesPrior pacemakerIndex hospitalizationIntensity statinsValve replacementConsecutive patientsPropensity matchingProcedural complicationsStatin regimenRetrospective studyStatin usageCardiac proceduresImpact of New-Onset Conduction Disturbances following Transcatheter Aortic Valve Replacement on Outcomes: A Single-Center Study
See C, Wang Y, Huang H, Parise H, Yang Y, Tirziu D, Francese D, Papoutsidakis N, Bader E, Kaple R, Cleman M, Lansky A, Forrest J. Impact of New-Onset Conduction Disturbances following Transcatheter Aortic Valve Replacement on Outcomes: A Single-Center Study. Journal Of Interventional Cardiology 2023, 2023: 5390338. PMID: 37292113, PMCID: PMC10247319, DOI: 10.1155/2023/5390338.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementNew-onset conduction disturbancesAortic valve replacementPersistent conduction disturbancesConduction disturbancesValve replacementSurgical aortic valve replacementSingle-center retrospective analysisYale-New Haven HospitalSingle-center studyCause mortality ratesCause mortality riskLong-term outcomesNew Haven HospitalPeriprocedural factorsAortic stenosisConsecutive patientsTAVR proceduresTerm outcomesRetrospective analysisMortality riskMortality ratePatientsOutcomesPatient's ECGB-50 | Full-Body Embolic Protection During Transcatheter Aortic Valve Replacement: The Protect the Head-to-Head Study, a Pivotal, Randomized Study Comparing the Emboliner Embolic Protection Catheter to the Sentinel CPS
Lansky A. B-50 | Full-Body Embolic Protection During Transcatheter Aortic Valve Replacement: The Protect the Head-to-Head Study, a Pivotal, Randomized Study Comparing the Emboliner Embolic Protection Catheter to the Sentinel CPS. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 100772. DOI: 10.1016/j.jscai.2023.100772.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementRandomized Study ComparingAortic valve replacementSentinel-CPSValve replacementEmbolic protectionHead studiesStudy ComparingCatheterProtectsCerebral Embolic Protection in Transcatheter Aortic Valve Replacement
Iskander M, Jamil Y, Forrest J, Madhavan M, Makkar R, Leon M, Lansky A, Ahmad Y. Cerebral Embolic Protection in Transcatheter Aortic Valve Replacement. Structural Heart 2023, 7: 100169. PMID: 37520138, PMCID: PMC10382985, DOI: 10.1016/j.shj.2023.100169.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementCerebral embolic protection devicesCerebral embolic protectionAortic valve replacementEmbolic protection devicesValve replacementEmbolic protectionSymptomatic severe aortic stenosisSevere aortic stenosisLow-risk patientsPredictors of strokeOccurrence of complicationsRisk of strokeRecent trial dataRelevant clinical studiesOverall evidence baseExpansion of TAVRFeared complicationAortic stenosisSurgical riskTreatment optionsWorse outcomesClinical studiesPatientsTrial data
2022
Self-expanding Transcatheter vs Surgical Aortic Valve Replacement in Intermediate-Risk Patients
Van Mieghem N, Deeb G, Søndergaard L, Grube E, Windecker S, Gada H, Mumtaz M, Olsen P, Heiser J, Merhi W, Kleiman N, Chetcuti S, Gleason T, Lee J, Cheng W, Makkar R, Crestanello J, George B, George I, Kodali S, Yakubov S, Serruys P, Lange R, Piazza N, Williams M, Oh J, Adams D, Li S, Reardon M, Gitter C, Meyer K, Roberts D, Bae R, Sorajja P, Sun B, Askew J, Eales F, Flavin T, Goessl M, Kshettry V, Mooney M, Pedersen W, Poulose A, Roohani P, Saeid Farivar R, Shronts R, Tarrel R, Young M, Butkus E, Pendleton K, Fry R, Heine C, La Roe K, Tran T, Weig L, Agarwal H, Langdon T, Satpathy R, Batter J, Bremer K, Indukuri U, Baas M, Oomes-Sistermans C, Smits M, Coenen C, Driesen I, Lauryssen L, Poorter M, Schaap J, Bentala M, den Heijer P, Pieter J, Remmers M, Story M, van Erven P, Verbiest H, Vos J, Bennett M, Dunaj W, Seaton D, Waller D, Khandheria B, Bajwa T, O'Hair D, Ahmed A, Allaqaband S, Gheith A, Marriott E, Qhavi A, Saxena V, Shhadeh A, Werner P, Yeomans C, Bessette L, Byrne J, Kieckhefer H, Munoz M, Russo E, Klein J, Morgan M, Byrne T, Caskey M, Amabile O, Brady K, Chung S, Dacanay K, Fang H, Franz D, Kelly C, Loli A, Payne J, Pershad A, Wang N, Lott J, Pool-Owens C, Porter C, Hennan J, Garrett H, Paulus B, Craig J, Elijovich L, Samaha J, Wolf B, Wright L, Zoghbi G, Willcott L, Roberts B, Hebeler R, Stoler R, Graybeal D, Grayburn P, Henry C, Mir O, Vallabhan R, Fanous M, Kaufman J, Chang J, Manning W, Riley M, Khabbaz K, Laham R, Popma J, Burke D, Caplan L, Chui S, Guibone K, Kumar S, Lioutas V, Liu D, Nathan S, Pinto D, Searls D, Fisher S, Guirgues L, Henderson S, Loving L, McWalters N, Patterson K, Burkart J, Carcedo B, Stacey R, Bladergroen M, Lim D, Edmonson S, Epps S, Katz M, Ng K, Sangha A, Aucoin J, Roberts M, Aubin J, Hotard C, Tassin M, Fail P, Feinberg E, Netherland D, Abben R, Allam M, Bates M, Dearman R, Gervais D, Haight E, Metes M, Naquin J, Tedesco V, Thibodeaux L, Thompson K, Aberle S, Amaro D, Grey W, Rose G, Scherer M, Rinaldi M, Skipper E, Bridges C, Downey W, Iyengar P, Martin J, Ryan L, Stiegel R, Story J, Alsabaawi K, Gheorghiu M, Singh C, Yashar J, Siegel R, Cheng W, Makkar R, Altman K, Jilaihawi H, Kar S, Khouw S, Mody C, Ramzy D, Salseth T, Stegic J, Trento A, Lazarte R, Sohn J, Hahn R, Khalique O, George I, Kodali S, Williams M, Gonzalez Castellon M, Gutierrez Contreras J, Kitago T, Kummer B, Lekic T, Miller E, Naka Y, Nazif T, Qureshi A, Rostanski S, Smith C, Willey J, Yaghi S, Abreu L, Clement E, Sabir S, Aji J, Bowen F, Kaddissi G, Mirsen T, Muntazar M, Ogbara J, Rosenbloom M, Schell W, Then R, Carl H, Huang H, Kreydi G, Wolak H, Sandidge G, Ali O, Asfaw Z, Henry S, Kafi A, Schreiber T, Andaya L, Baciewicz F, Bassett J, Choksi N, Kassas S, Munir A, Kothmeier F, Stroh A, Goppel G, Hettich I, Bleiziffer S, Hengstenberg C, Opitz A, Ruge H, Badiu C, Brenner S, Ehlmidi Y, Herold U, Kasel A, Kreuzpointner R, Lange R, Mazzitelli D, Poppert H, Seifert C, Vincze D, Voss B, Camuglia K, Cowhig D, Newbold S, Pierce C, Wootton S, Vemulapalli S, Velazquez E, Harrison J, Hughes G, Ali Y, Babi A, Banks A, Gaca J, Glower D, Gokhale S, Halim S, Hendry R, Hernandez C, Kiefer T, Klein M, Kolls B, Marrotte E, Pineda Maldonado A, Price A, Sherwood M, Swisher C, Van Wyck D, Vavalle J, Vora A, Wang A, Zeylikman Y, Amber K, Barnitt A, Lamm J, Mandelstam L, Schroeder R, Sumner R, Nair D, De A, Gaudiani V, Joye J, Brown L, Hessler C, Rammohan C, Vial C, Charles E, DeQuesada A, Kaner M, Mathewson S, Pitts K, Wheeler L, Wilson A, Davidson E, Frohwein S, Lerakis S, Merlino J, Sullivan A, Babaliaros V, Guyton R, Thourani V, Anderson A, Belagaje S, Benameur K, Devireddy C, Greene J, Harrison A, Hudson K, Leshnower B, Lieppe W, Macheers S, Mavromatis K, Miller J, Nahab F, Sanders K, Sarin E, Stewart J, Winkel D, Duininck L, Gussinklo T, Jadoenath-Oedai S, Ruiter A, van den Berg N, van der Velden-Macauley L, van Huis M, Verelst S, Geleijnse M, Vletter W, Bekker M, Kappetein A, Van Mieghem N, Bekkers J, Biesheuvel K, Birim O, Bol Raap G, Daemen J, de Jaegere P, de Lind van Wijngaarden R, Khajeh L, Kik C, Koudstaal P, Oei F, Scheele M, van de Woestijne P, van Geuns R, van Leeuwen W, Henderson A, Straight F, Schneider D, Tischler M, Dauerman H, Ittleman F, Schmoker J, Abernethy A, Alkhalil I, Azarbal A, Chava S, Commichau C, Coyle D, Denkmann J, Destephan C, Ehle G, El-Haddad M, Falduto C, Gorman M, Kadavath S, Leavitt B, Mack A, Malasana G, Moossavi S, Phuong N, Rambod M, Seecheran N, Sharma A, Terrien E, Worgan B, Zeglin-Sawczuk M, Burgess B, Killbride S, Temple A, Burnside J, Good C, Agarwal S, Casale A, Skelding K, Carter R, Cummings C, Grana V, Haegerl C, Harjai K, Holland N, Singh D, Stahl R, Stella J, Stewart B, Long D, Wood K, Alexander D, Barton S, Logtens E, Marsh A, McAdam J, Kovac J, Mariscalco G, Spyt T, Garimella S, Szostek J, Zlocha V, Kirkland L, Reid L, Reilly S, Menderhall M, Martin W, Park S, Seshiah P, Smith J, Gersch K, Hiratzka L, Kachoris J, Okum E, Cardozo M, Cyr G, Duvall W, Flynn A, Krupowies N, Parker M, Hagberg R, McKay R, Azemi T, Brown R, Fusco D, Hammond J, Hosley C, Kiernan F, Margey R, Preissler P, Sadiq I, Silverman I, Taboada S, Underhill D, Escobar J, Lopez B, Mullin S, Quesada C, Lawrence T, Naqvi T, Matthews R, Starnes V, Clavijo L, Cunningham M, Kim-Tenser M, Sanossian N, Shavelle D, DelMotte D, Henry S, Moltrassie J, Solanki A, Cooper R, Lee J, Parikh S, Wang D, Zweig B, O'Neill W, Paone G, Borgi J, Brewer R, Eng M, Greenbaum A, Guerrero M, Miller D, Mitsias P, Morgan J, Nemeh H, Alcaide Muñoz J, Medina Fernandez M, Carrasco Chinchilla F, Rodríguez Bailón I, Hernández García J, Such M, Alonso-Briales J, De La Cruz Cosme C, Dominguez-Franco A, Mataró López M, Melero J, Muñoz-Garcia A, Sanchez Espin G, Fernández Maese J, Torres M, Villa Suarez E, De La Hera J, Llosa Cortina J, Morís de la Tassa C, Avanzas Fernández P, Benavente Fernández L, Calleja S, Del Valle R, Morales Pérez C, Silva J, Bluntschli E, Keller D, Maritz S, Ruest R, 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Radford N, Sookhoo V, Kyereme K, Punzalan R, Reynolds R, Sculeany B, Sharma R, Stuart A, Brecker S, Jahangiri M, Alassa A, Chandrasekaran V, Clarke B, Dowling C, Moynihan B, Roy D, Sarsam M, Bess R, Henkel M, Herbert N, Cohen G, Batra S, Davis T, Aboukasm A, Cullis P, LaLonde T, Martin J, Yamasaki H, Burkert M, Kingma B, Wheatley J, Segar D, Heimansohn D, Hermiller J, Ball M, Elsner G, Hanan S, Moainie S, Nukes T, Reibold P, Robison R, Salerno C, Sampson A, Walts P, Wandel E, Li M, Sarker S, Ahmed S, Fremes S, Radhakrishnan S, Arbel Y, Christakis G, Cohen G, Czarnecki A, Elbaz-Greener G, Feld Y, Hopyan J, Komatsu I, McCraig K, Shuvy M, Toma J, Vincenzo B, Wheeler C, Wijeysundera H, Wolff R, Beck P, Cabral D, DaCosta C, Hudson L, Pastie M, Abrahams N, Altamar I, Buitrago M, Cassman G, Leibovici Z, Nelson A, Recchia K, Robbins G, Studor K, Bethea B, Beyer E, Evans S, Goodis C, Malek A, Mueller-Kronast N, Pan H, Pantoja C, Ramos A, Wells C, Youngblood C, Snelus P, Gopal D, Jackson K, Brown D, Ryan W, Brinkman W, Gopal A, Harrington K, Mack M, Nosnik P, Potluri S, Smith R, Szerlip M, Blaylock C, Brinegar P, Canter L, Green L, Green L, Hazen P, Jacobs A, Khan S, Ludwig S, Mata M, Moore T, Underwood C, Faza N, Little S, Nagueh S, Kleiman N, Reardon M, Albright K, Atkins M, Barker C, Bledsoe D, Chiu D, Goel S, Gray T, Imperial-Aubin D, Lin C, Moye S, Ramchandani M, Ramlawi B, Reul R, Reyes M, Scheinin S, Volpi J, White S, Wyler von Ballmoos M, Blackburn B, Wong R, Hart C, Whitacker P, Lau J, Spies C, Badawi R, Graner S, Nakamura D, Plank B, Salem R, Seto T, Valenta D, Cruz A, Gallagher L, Schuck L, Siki M, Weeks A, Fishman L, Schwarz T, Bavaria J, Herrmann H, Anwaruddin S, Desai N, Giri J, Khella S, Li R, McGarvery M, Messe S, Price R, Quinn C, Szeto W, Vallabhajosyula P, Sun Y, Wu L, Tsang W, Thavendiranathan D, Feindel C, Horlick E, Casaubon L, Cusimano R, Del Campo M, Osten M, Silver F, Höwisch-Pengel R, Lechner G, Steiger B, Allgeier M, Jander N, Beyersdorf F, Neumann F, Büttner H, Comberg T, Diab N, Gick M, Günkel L, Pingpoh C, Rothe H, Siepe M, Thoma M, Winker T, Hager C, Sänger U, Stader M, Biaggi P, Gruner C, Stämpfli S, Binder R, Corti R, Falk V, Holy E, Maisano F, Grünenfelder J, Holubec T, Maier W, Nietlispach F, Wegener S, Atkinson R, Davis A, Hall S, Mangene S, Mazzurco S, Hoit B, Musarra R, Costa M, Markowitz A, Asi K, Attizzani G, Chuang D, Elgudin Y, Garcia C, Jadhav V, Le S, Miller B, Serkin Z, Shams T, Sila C, Simon D, Bezerra H, Deo S, Anderson J, Greening K, Karson J, Page S, Shawgo T, Freeman J, Mulhern K, Nath J, Tadros P, Zorn G, Hockstad E, Lechtenberg C, Muehlebach G, Rippee M, Rosterman L, Sundararajan J, Wang Y, Wiley M, Atapattu S, Marin y Kall C, Lowery M, de Marchena E, Salerno T, Alfonso C, Carillo R, Ferreira A, Panos A, Romano J, Williams D, Bhatt S, Migda E, Oakley J, Warshal W, Wilcock S, Booher A, LaBounty T, Chetcuti S, Deeb G, Adelman E, Boyle M, Geml R, Grossman P, Guerin D, Hodges K, Kim K, Lammers D, McDermott M, Menees D, Pace R, Patel H, Prager R, Ramchandren S, Romano M, Stamper A, Wang M, Zahuranec D, Ziarkiewicz M, Charlebois C, Chilton C, Labinaz M, Ruel M, Glover C, Lam K, Masters R, Steffenhagen N, Enlow-Germovsek M, Konopka K, McGargle R, Travis M, Anderson K, Cavalcante J, Crock F, Edelman K, Katz W, Gleason T, Lee J, Sultan I, Aghaebrahim A, Al-Bayai A, Bonaccorsi C, Campbell D, Giurgiutiu D, Gulati D, Hawkes C, Henry L, Jadhav A, Kenmuir C, Klein B, Kliner D, Limaye K, Nanduri S, Navid F, Patel P, Rangaraju S, Rocha M, Schindler J, Shoirah H, Streib C, Tadi P, Tememe D, Totoraitis R, Walker G, Ziayee H, Caufield L, Yeager C, Forbes J, Schwart K, Knight P, Ling F, Benesch C, Bogachan S, Hicks G, Kelly A, Narins C, Stuver T, Adams K, Blair-Anton L, Haynes M, Watts C, Baker M, Mendes L, Ball S, Goel K, Kaiser C, Robbins M, Zhao D, Ahmad R, Crenshaw M, Fredi J, Hermann L, Hoff S, Kirshner H, Levack M, Mittal S, O'Duffy A, Petracek M, Baer J, Liang G, Nguyen S, Heidenreich P, Nguyen P, Burdon T, Giacomini J, Yong C, Buchbinder M, Fann J, Kilgore S, Mitchell R, McDaniel S, Pack A, White W, Young T, Burgess P, Pu M, Upadhya B, Applegate R, Kon N, Arnan M, Baghshomali S, Bishop L, Bradbury E, Gandhi S, Kincaid E, Lefkowitz D, Lisle B, Batteria M, Rerisi E, Stepinowski K, Senicola T, Goncalves J, Schubach S, Schwartz R, Antaky K, Christiansen C, Marzo K, Michel K, Misra A, Varghese P, Wirkowski E, Levesque L, Sugeng L, Cleman M, Forrest J, Hashim S, Mangi A, Amin H, Darr U, Dewar M, Faheem O, Geirsson A, Greer D, Kaleel A, Kaple R, Lansky A, MacGrory B, Pfau S, Schindler J, Thompson C, Youn T, Yuh D, Yun J. Self-expanding Transcatheter vs Surgical Aortic Valve Replacement in Intermediate-Risk Patients. JAMA Cardiology 2022, 7: 1000-1008. PMID: 36001335, PMCID: PMC9403849, DOI: 10.1001/jamacardio.2022.2695.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementAortic valve replacementSevere aortic valve stenosisIntermediate-risk patientsAortic valve stenosisValve replacementAdverse eventsAortic stenosisValve stenosisParavalvular leakClinical trialsIndependent echocardiographic core laboratorySurgical aortic valve replacementSymptomatic severe aortic stenosisIndependent clinical events committeePrespecified secondary end pointsEchocardiographic core laboratoryIntermediate surgical riskIntermediate-risk subjectsLocal heart teamSecondary end pointsSerious adverse eventsSevere aortic stenosisSymptomatic aortic stenosisAortic valve area
2021
A randomized evaluation of the TriGuard™ HDH cerebral embolic protection device to Reduce the Impact of Cerebral Embolic LEsions after TransCatheter Aortic Valve ImplanTation: the REFLECT I trial
Lansky AJ, Makkar R, Nazif T, Messé S, Forrest J, Sharma R, Schofer J, Linke A, Brown D, Dhoble A, Horwitz P, Zang M, DeMarco F, Rajagopal V, Dwyer MG, Zivadinov R, Stella P, Rovin J, Parise H, Kodali S, Baumbach A, Moses J. A randomized evaluation of the TriGuard™ HDH cerebral embolic protection device to Reduce the Impact of Cerebral Embolic LEsions after TransCatheter Aortic Valve ImplanTation: the REFLECT I trial. European Heart Journal 2021, 42: 2670-2679. PMID: 34000004, DOI: 10.1093/eurheartj/ehab213.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementEfficacy endpointCerebral embolic protection devicesTranscatheter aortic valve implantationCentral nervous system injuryCerebral embolic lesionsCerebral ischemic lesionsHealth Stroke ScalePrimary efficacy endpointPrimary safety outcomeAortic valve replacementAortic valve implantationEmbolic protection devicesNervous system injuryDiffusion-weighted magnetic resonanceMontreal Cognitive AssessmentEffectiveness endpointCause mortalityCerebral protectionSafety endpointStroke ScaleValve implantationValve replacementI trialIschemic lesionsRandomized Evaluation of TriGuard 3 Cerebral Embolic Protection After Transcatheter Aortic Valve Replacement REFLECT II
Nazif TM, Moses J, Sharma R, Dhoble A, Rovin J, Brown D, Horwitz P, Makkar R, Stoler R, Forrest J, Messé S, Dickerman S, Brennan J, Zivadinov R, Dwyer MG, Lansky AJ, Investigators R. Randomized Evaluation of TriGuard 3 Cerebral Embolic Protection After Transcatheter Aortic Valve Replacement REFLECT II. JACC Cardiovascular Interventions 2021, 14: 515-527. PMID: 33663779, DOI: 10.1016/j.jcin.2020.11.011.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementAortic valve replacementSafety endpointValve replacementProcedure-related ischemic strokeCerebral embolic protectionComposite efficacy endpointPrimary safety endpointCerebral embolizationCerebral protectionEfficacy endpointII trialCerebral injuryIschemic strokeEmbolic protectionPatientsDrug AdministrationUS sitesU.S. FoodEndpointData reviewTrialsMulticenterEmbolizationInjury
2020
Adjunctive Antithrombotic Therapy for Patients With Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement
Saito Y, Nazif T, Baumbach A, Tchétché D, Latib A, Kaple R, Forrest J, Prendergast B, Lansky A. Adjunctive Antithrombotic Therapy for Patients With Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement. JAMA Cardiology 2020, 5: 92-101. PMID: 31721980, DOI: 10.1001/jamacardio.2019.4367.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementAortic valve replacementAdjunctive antithrombotic therapyDual antiplatelet therapyAntithrombotic therapyAntiplatelet therapyValve replacementAortic stenosisAortic stenosis (AS) undergoing transcatheter aortic valve replacementSevere symptomatic aortic stenosisSurgical aortic valve replacementGuideline-recommended regimenOral anticoagulant useSevere aortic stenosisSingle antiplatelet therapySymptomatic aortic stenosisPatient risk factorsOngoing clinical trialsRisk prediction modelMajor bleedingOral anticoagulationAnticoagulant useStroke riskTAVR proceduresThrombotic risk
2016
Transcatheter Aortic Valve Replacement in Women Versus Men (from the US CoreValve Trials)
Forrest JK, Adams DH, Popma JJ, Reardon MJ, Deeb GM, Yakubov SJ, Hermiller JB, Huang J, Skelding KA, Lansky A. Transcatheter Aortic Valve Replacement in Women Versus Men (from the US CoreValve Trials). The American Journal Of Cardiology 2016, 118: 396-402. PMID: 27346591, DOI: 10.1016/j.amjcard.2016.05.013.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic Valve StenosisCause of DeathComorbidityFemaleFrail ElderlyHumansIncidenceMaleMortalityPostoperative ComplicationsPostoperative HemorrhageSeverity of Illness IndexSex FactorsStrokeTranscatheter Aortic Valve ReplacementTreatment OutcomeVentricular Dysfunction, LeftConceptsTranscatheter aortic valve replacementAortic valve replacementCoreValve prosthesisValve replacementSevere symptomatic aortic stenosisSurgical aortic valve replacementLeft ventricular systolic functionWomen Versus MenMajor vascular complicationsSymptomatic aortic stenosisIncidence of strokeProcedure-related complicationsVentricular systolic functionCoronary artery diseaseLife-threatening bleedsSignificant baseline differencesGender-related differencesCause mortalityVascular complicationsBaseline characteristicsPatient characteristicsPrevious strokeSystolic functionAortic stenosisArtery disease
2015
TCT-623 Transcatheter Aortic Valve Replacement In Women Versus Men: An Analysis of the CoreValve US Pivotal and Continued Access Trials
Forrest J, Lansky A, Maini B, Skelding K, Casale A, Fail P, Popma J. TCT-623 Transcatheter Aortic Valve Replacement In Women Versus Men: An Analysis of the CoreValve US Pivotal and Continued Access Trials. Journal Of The American College Of Cardiology 2015, 66: b254-b255. DOI: 10.1016/j.jacc.2015.08.642.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementWomen Versus MenAortic valve replacementValve replacementAccess trialTrialsThe TriGuard embolic deflection device for prevention of stroke and cerebral embolization during transcatheter aortic valve replacement
Baumbach A, Pietras C, Lansky A. The TriGuard embolic deflection device for prevention of stroke and cerebral embolization during transcatheter aortic valve replacement. Expert Review Of Medical Devices 2015, 12: 649-651. PMID: 26364995, DOI: 10.1586/17434440.2015.1086642.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve implantationAortic valve implantationValve implantationTranscatheter aortic valve replacementIschemic cerebral eventsAortic valve replacementPrevention of strokeCerebral embolizationEmbolic strokeCerebral eventsEmbolic eventsValve replacementEmbolic lesionsClinical studiesNeurocognitive impairmentNeurocognitive functionMemory lossVessel ostiumStrokeBrain circulationImplantationEmbolizationOstiumLesionsIncidenceSafety and performance of a novel embolic deflection device in patients undergoing transcatheter aortic valve replacement: results from the DEFLECT I study.
Baumbach A, Mullen M, Brickman AM, Aggarwal SK, Pietras CG, Forrest JK, Hildick-Smith D, Meller SM, Gambone L, den Heijer P, Margolis P, Voros S, Lansky AJ. Safety and performance of a novel embolic deflection device in patients undergoing transcatheter aortic valve replacement: results from the DEFLECT I study. EuroIntervention 2015, 11: 75-84. PMID: 25868876, DOI: 10.4244/eijy15m04_01.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAlloysAortic ValveAortic Valve StenosisBrain IschemiaBrazilCardiac CatheterizationCognitionCognition DisordersDiffusion Magnetic Resonance ImagingEmbolic Protection DevicesEuropeFemaleHeart Valve ProsthesisHeart Valve Prosthesis ImplantationHumansIntracranial EmbolismMalePredictive Value of TestsProspective StudiesProsthesis DesignRisk FactorsSeverity of Illness IndexStrokeTime FactorsTreatment OutcomeUltrasonography, Doppler, TranscranialConceptsTranscatheter aortic valve replacementAortic valve replacementValve replacementNew cerebral ischemic lesionsCerebral diffusion-weighted magnetic resonance imagingCerebral ischemic lesionsDays post procedurePrimary safety endpointDiffusion-weighted magnetic resonance imagingMajor cerebral arteriesTotal lesion volumeMagnetic resonance imagingSafety endpointIschemic lesionsTAVR proceduresCerebral arteryCerebral circulationConsecutive subjectsPost procedureAortic archHistorical controlsLesion volumeResonance imagingDW-MRIPatients
2013
Clinical implications for diffusion‐weighted MRI brain lesions associated with transcatheter aortic valve replacement
Meller SM, Baumbach A, Brickman AM, Lansky AJ. Clinical implications for diffusion‐weighted MRI brain lesions associated with transcatheter aortic valve replacement. Catheterization And Cardiovascular Interventions 2013, 83: 502-508. PMID: 23460315, DOI: 10.1002/ccd.24904.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementAortic valve replacementSilent strokeValve replacementCerebral embolic protection devicesDiffusion-weighted magnetic resonance imagingEmbolic protection devicesCerebral protection devicesMRI brain lesionsPotential therapeutic optionQuality of lifeLong-term cognitive consequencesMagnetic resonance imagingNeurological complicationsAortic stenosisImproved survivalNew lesionsEmbolic lesionsTherapeutic optionsBrain lesionsRisk candidatesCognitive declineResonance imagingClinical implicationsLesions