2012
Use of a Novel Crossing and Re-Entry System in Coronary Chronic Total Occlusions That Have Failed Standard Crossing Techniques Results of the FAST-CTOs (Facilitated Antegrade Steering Technique in Chronic Total Occlusions) Trial
Whitlow PL, Burke MN, Lombardi WL, Wyman RM, Moses JW, Brilakis ES, Heuser RR, Rihal CS, Lansky AJ, Thompson CA, Investigators F. Use of a Novel Crossing and Re-Entry System in Coronary Chronic Total Occlusions That Have Failed Standard Crossing Techniques Results of the FAST-CTOs (Facilitated Antegrade Steering Technique in Chronic Total Occlusions) Trial. JACC Cardiovascular Interventions 2012, 5: 393-401. PMID: 22516395, DOI: 10.1016/j.jcin.2012.01.014.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryCathetersChronic DiseaseCoronary AngiographyCoronary OcclusionDrug-Eluting StentsEquipment DesignFemaleHumansMaleMiddle AgedMyocardial InfarctionPredictive Value of TestsProspective StudiesProsthesis DesignRetreatmentTime FactorsTreatment FailureUnited StatesConceptsCoronary chronic total occlusionsElevation myocardial infarctionPercutaneous coronary interventionChronic total occlusionCrossing catheterTotal occlusionMyocardial infarctionMajor adverse cardiac event ratesST-segment elevation myocardial infarctionAdverse cardiac event ratesSuccessful percutaneous coronary interventionSegment elevation myocardial infarctionCardiac event ratePrimary efficacy endpointRe-entry catheterSingle-arm trialCTO-PCI successMean lesion lengthDistal true lumenCardiac reinterventionEfficacy endpointCoronary interventionEmergency surgeryHemodynamic instabilityPCI success
2011
Initial experience with a dedicated coronary re‐entry device for revascularization of chronic total occlusions
Whitlow PL, Lombardi WL, Araya M, Wyman R, Torres H, Dauvergne C, Tsuchikane E, Lansky A, Thompson CA. Initial experience with a dedicated coronary re‐entry device for revascularization of chronic total occlusions. Catheterization And Cardiovascular Interventions 2011, 80: 807-813. PMID: 22121076, DOI: 10.1002/ccd.23417.Peer-Reviewed Original ResearchConceptsChronic total coronary occlusionsDistal true lumenRe-entry deviceTrue lumenAntegrade guidewireWire entrapmentTIMI 3 flowTotal coronary occlusionChronic total occlusionGuidewire penetrationConsecutive CTO lesionsPrimary endpointProspective registryClinical improvementSuccessful recanalizationCoronary perforationMajor complicationsCTO lesionsCoronary occlusionCTO interventionTotal occlusionLesion characteristicsSubintimal spaceRetrograde techniqueInitial experience
2003
Usefulness of the angiographic pattern of in-stent restenosis in predicting the success of gamma vascular brachytherapy
Costantini CO, Lansky AJ, Mintz GS, Shirai K, Dangas G, Mehran R, Stone GW, Leon MB. Usefulness of the angiographic pattern of in-stent restenosis in predicting the success of gamma vascular brachytherapy. The American Journal Of Cardiology 2003, 92: 1214-1217. PMID: 14609602, DOI: 10.1016/j.amjcard.2003.07.036.Peer-Reviewed Original ResearchConceptsStent restenosisAngiographic patternsVascular brachytherapyMajor adverse cardiac event ratesAdverse cardiac event ratesBinary angiographic restenosis rateAngiographic restenosis rateCardiac event rateStent restenosis patternsRestenosis patternLesion revascularizationPrognostic roleRestenosis rateTotal occlusionClinical trialsProliferative patternEvent ratesRestenosisPooled data setBrachytherapyRevascularizationPatientsAngiogramsBaselineTrials
2002
Balloon‐based radiation therapy for treatment of in‐stent restenosis in human coronary arteries: Results from the BRITE I study
Waksman R, Buchbinder M, Reisman M, Lansky AJ, Trauthen B, Whiting J, Li A. Balloon‐based radiation therapy for treatment of in‐stent restenosis in human coronary arteries: Results from the BRITE I study. Catheterization And Cardiovascular Interventions 2002, 57: 286-294. PMID: 12410499, DOI: 10.1002/ccd.10359.Peer-Reviewed Original ResearchMeSH KeywordsAgedArteriesBlood Vessel ProsthesisCatheterizationCoronary AngiographyCoronary RestenosisDose-Response Relationship, RadiationFemaleFollow-Up StudiesHumansIncidenceMaleMiddle AgedPilot ProjectsProspective StudiesRadiotherapy, Computer-AssistedReoperationRisk FactorsStentsTime FactorsTreatment OutcomeConceptsStent restenosisRadiation therapyMajor adverse cardiac eventsAdverse cardiac eventsIntracoronary radiation therapyStudy eligibility criteriaStent restenosis resultsInstances of deathHuman coronary arteriesBinary restenosisRepeat PTCAPrimary endpointCardiac eventsClinical restenosisEmergency surgeryLate complicationsAngioplasty siteRestenosis rateRecurrence rateTotal occlusionConventional therapyCoronary arteryEligibility criteriaLate thrombosisTarget vesselFive-year clinical and angiographic follow-up after intracoronary iridium-192 radiation therapy
Condado JA, Waksman R, Saucedo JF, Bhargava B, Lansky AJ, Calderas C, Gurdiel O, Gonzalez J, Fadoul M, Parra B, Iturria I, Amezaga B. Five-year clinical and angiographic follow-up after intracoronary iridium-192 radiation therapy. Cardiovascular Revascularization Medicine 2002, 3: 74-81. PMID: 12699836, DOI: 10.1016/s1522-1865(03)00077-5.Peer-Reviewed Original ResearchConceptsQuantitative coronary analysisIntracoronary gamma radiationBalloon angioplastyRadiation therapyAngiographic complicationsStandard balloon angioplastyBinary restenosis rateIntracoronary radiation therapyIncidence of restenosisNew adverse effectsPrevention of restenosisLesion revascularizationUnstable anginaAngioplasty siteRestenosis rateNontarget vesselsTotal occlusionMyocardial infarctionAngiographic effectsClinical trialsAneurysm formationLate lossNeointimal formationLong-term effectsPatients
2000
Intracoronary brachytherapy not associated with changes in major side branches
Cottin Y, Lansky A, Kim H, Kollum M, Abrahimi A, Mehran R, Bhargava B, Chan R, Waksman R. Intracoronary brachytherapy not associated with changes in major side branches. Catheterization And Cardiovascular Interventions 2000, 51: 154-158. PMID: 11025567, DOI: 10.1002/1522-726x(200010)51:2<154::aid-ccd5>3.0.co;2-v.Peer-Reviewed Original ResearchConceptsSide branch occlusionMajor side branchesIntravascular radiationIntracoronary brachytherapyIrradiated groupSide branchesLate coronary occlusionTreatment of restenosisBaseline patientConsecutive patientsCoronary occlusionPatency ratesTotal occlusionSignificant stenosisLesion characteristicsTarget lesionsControl groupLow dosesPatientsAdverse effectsOcclusionHealing processSignificant decreaseStenosisRestenosisLate total occlusion after intracoronary brachytherapy for patients with in-stent restenosis
Waksman R, Bhargava B, Mintz G, Mehran R, Lansky A, Satler L, Pichard A, Kent K, Leon M. Late total occlusion after intracoronary brachytherapy for patients with in-stent restenosis. Journal Of The American College Of Cardiology 2000, 36: 65-68. PMID: 10898414, DOI: 10.1016/s0735-1097(00)00681-1.Peer-Reviewed Original ResearchConceptsLate total occlusionPlacebo patientsStent restenosisIntracoronary radiationIrradiated groupAntiplatelet therapyTotal occlusionAcute myocardial infarctionEntire study groupUnstable anginaIntracoronary brachytherapyMyocardial infarctionRadiation protocolStudy groupLate thrombosisPatientsRestenosisMultivariate analysisMaximum doseMean timeNew stentTime of radiationVessel wallMonthsOverall rateImportance of lesion length on new device angioplasty of native coronary arteries
Saucedo J, Kennard E, Popma J, Talley D, Lansky A, Leon M, Baim D. Importance of lesion length on new device angioplasty of native coronary arteries. Catheterization And Cardiovascular Interventions 2000, 50: 19-25. PMID: 10816274, DOI: 10.1002/(sici)1522-726x(200005)50:1<19::aid-ccd4>3.0.co;2-h.Peer-Reviewed Original ResearchConceptsTarget lesion revascularizationNew device angioplastyMore target lesion revascularizationLesion revascularizationLong lesionsLesion lengthRight coronary artery diseaseSmaller minimal lumen diameterLong lesion groupMore multivessel diseaseNative coronary arteriesCoronary artery diseaseCoronary Intervention RegistryEarly clinical eventsMinimal lumen diameterLonger lesion lengthMultivessel diseaseAngiographic outcomesIntervention RegistryArtery diseaseClinical outcomesHospital eventsTotal occlusionClinical eventsCoronary arteryEffect of plaque debulking and stenting on short- and long-term outcomes after revascularization of chronic total occlusions
Gruberg L, Mehran R, Dangas G, Hong M, Mintz G, Kornowski R, Lansky A, Kent K, Pichard A, Satler L, Stone G, Leon M. Effect of plaque debulking and stenting on short- and long-term outcomes after revascularization of chronic total occlusions. Journal Of The American College Of Cardiology 2000, 35: 151-156. PMID: 10636273, DOI: 10.1016/s0735-1097(99)00491-x.Peer-Reviewed Original ResearchConceptsLesion revascularization rateChronic total occlusionRevascularization ratesClinical outcomesTotal occlusionCoronary arteryStent deploymentTarget lesion revascularization rateLong-term clinical outcomesCoronary artery locationLate clinical outcomesPrimary success rateNative coronary arteriesGroup of patientsCoronary artery occlusionLong-term outcomesSuccessful stent deploymentNew interventional devicesEffect of plaqueAngioplasty ratesHospital mortalityLesion modificationSuccessful stentingAngiographic characteristicsHospital outcomes
1998
Intracoronary Radiation Post PTCA Prevents Late Arterial Constriction
WAKSMAN R, CONDADO J, SAUCEDO J, LANSKY A, POPMA J, KLEIN J, CROCKER I, WILLIAMS D, KING S. Intracoronary Radiation Post PTCA Prevents Late Arterial Constriction. Journal Of Interventional Cardiology 1998, 11: 535-541. DOI: 10.1111/j.1540-8183.1998.tb00165.x.Peer-Reviewed Original ResearchPost-PTCABalloon angioplastyIntracoronary radiationLate lossLate loss indexLower late lossVascular remodeling effectDe novo lesionsIntracoronary radiation therapyPilot clinical studyMechanism of restenosisNovo lesionsRestenosis rateRadiation trialsPositive remodelingTotal occlusionArterial constrictionClinical studiesVascular remodelingRadiation therapyNeointima formationAnimal modelsPatientsRemodeling effectTrials