2016
Impact of TCFA on Unanticipated Ischemic Events in Medically Treated Diabetes Mellitus Insights From the PROSPECT Study
Kedhi E, Kennedy MW, Maehara A, Lansky AJ, McAndrew TC, Marso SP, De Bruyne B, Serruys PW, Stone GW. Impact of TCFA on Unanticipated Ischemic Events in Medically Treated Diabetes Mellitus Insights From the PROSPECT Study. JACC Cardiovascular Imaging 2016, 10: 451-458. PMID: 27372016, DOI: 10.1016/j.jcmg.2015.12.023.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedChi-Square DistributionCoronary AngiographyCoronary Artery DiseaseCoronary VesselsDiabetes MellitusDisease ProgressionFemaleFibrosisHumansMaleMiddle AgedPercutaneous Coronary InterventionPlaque, AtheroscleroticPredictive Value of TestsPropensity ScoreRisk FactorsRupture, SpontaneousTime FactorsTreatment OutcomeUltrasonography, InterventionalConceptsMajor adverse cardiac eventsAcute coronary syndromeThin-cap fibroatheromaNonculprit lesionsDiabetes mellitusACS patientsDM patientsSubsequent major adverse cardiac eventsPresence of DMPROSPECT studyAdverse cardiac eventsPropensity-matched groupsRadiofrequency intravascular ultrasoundHigh rateCoronary syndromeCardiac eventsPlaque compositionIntravascular ultrasoundPatientsPropensity scoreBalanced groupsIschemicMellitusFibroatheromaPrognosis
2014
Relation of C-Reactive Protein Levels to Instability of Untreated Vulnerable Coronary Plaques (from the PROSPECT Study)
Kelly CR, Weisz G, Maehara A, Mintz GS, Mehran R, Lansky AJ, Parise H, de Bruyne B, Serruys PW, Stone GW. Relation of C-Reactive Protein Levels to Instability of Untreated Vulnerable Coronary Plaques (from the PROSPECT Study). The American Journal Of Cardiology 2014, 114: 376-383. PMID: 24931291, DOI: 10.1016/j.amjcard.2014.04.048.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiomarkersCoronary AngiographyCoronary Artery DiseaseC-Reactive ProteinDisease ProgressionFemaleGlobal HealthHumansIncidenceInflammationMaleMiddle AgedPlaque, AtheroscleroticPredictive Value of TestsPrognosisProspective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexSurvival RateTime FactorsConceptsMajor adverse cardiac eventsC-reactive protein levelsNonculprit lesionsElevated CRP levelsCRP levelsVulnerable coronary plaquesIntravascular ultrasoundCoronary plaquesPost-acute coronary syndrome patientsSubsequent major adverse cardiac eventsGray-scale intravascular ultrasoundCoronary Tree (PROSPECT) studyUntreated nonculprit lesionsAdverse cardiac eventsAdverse coronary eventsAcute coronary syndromeCoronary syndrome patientsPercutaneous coronary interventionRadiofrequency intravascular ultrasoundPredictors of eventsProtein levelsMinimal luminal areaHigh rateCoronary eventsCoronary syndrome
2012
Age- and gender-related changes in plaque composition in patients with acute coronary syndrome: the PROSPECT study.
Ruiz-García J, Lerman A, Weisz G, Maehara A, Mintz GS, Fahy M, Xu K, Lansky AJ, Cristea E, Farah TG, Teles R, Botker HE, Templin B, Zhang Z, de Bruyne B, Serruys PW, Stone GW. Age- and gender-related changes in plaque composition in patients with acute coronary syndrome: the PROSPECT study. EuroIntervention 2012, 8: 929-38. PMID: 23253546, DOI: 10.4244/eijv8i8a142.Peer-Reviewed Original ResearchConceptsMajor adverse cardiac eventsAcute coronary syndromeNon-culprit lesionsUntreated non-culprit lesionsCoronary syndromePlaque burdenIncidence of MACEAge groupsObstructive coronary artery diseaseNecrotic coreGreater plaque burdenLarger plaque volumeAdverse cardiac eventsCoronary artery diseaseRadiofrequency intravascular ultrasoundYears of ageSame age groupGender-specific differencesSex-related effectsCardiac eventsArtery diseaseAdverse outcomesAtherosclerosis developmentCoronary plaquesGender-related changesResidual Plaque Burden in Patients With Acute Coronary Syndromes After Successful Percutaneous Coronary Intervention
McPherson JA, Maehara A, Weisz G, Mintz GS, Cristea E, Mehran R, Foster M, Verheye S, Rabbani L, Xu K, Fahy M, Templin B, Zhang Z, Lansky AJ, de Bruyne B, Serruys PW, Stone GW. Residual Plaque Burden in Patients With Acute Coronary Syndromes After Successful Percutaneous Coronary Intervention. JACC Cardiovascular Imaging 2012, 5: s76-s85. PMID: 22421234, DOI: 10.1016/j.jcmg.2012.01.005.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryChi-Square DistributionCoronary AngiographyCoronary Artery DiseaseCoronary StenosisEuropeFemaleHumansKaplan-Meier EstimateLogistic ModelsMaleMiddle AgedNecrosisPlaque, AtheroscleroticPredictive Value of TestsProportional Hazards ModelsProspective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexTime FactorsTreatment OutcomeUltrasonography, InterventionalUnited StatesVascular CalcificationConceptsMajor adverse cardiovascular eventsSuccessful percutaneous coronary interventionPercutaneous coronary interventionAcute coronary syndromePlaque burdenThin-cap fibroatheromaNonculprit lesionsIntravascular ultrasoundCardiovascular eventsCoronary syndromeCoronary interventionAtherosclerotic diseaseSignificant lesionsFuture major adverse cardiovascular eventsPrior percutaneous coronary interventionMean diameter stenosisMean plaque burdenPercent plaque volumeResidual plaque burdenUntreated nonculprit lesionsAdverse cardiovascular eventsFuture cardiovascular eventsCoronary artery diseaseRadiofrequency intravascular ultrasoundAtherosclerotic burdenDefinitions and Methodology for the Grayscale and Radiofrequency Intravascular Ultrasound and Coronary Angiographic Analyses
Maehara A, Cristea E, Mintz GS, Lansky AJ, Dressler O, Biro S, Templin B, Virmani R, de Bruyne B, Serruys PW, Stone GW. Definitions and Methodology for the Grayscale and Radiofrequency Intravascular Ultrasound and Coronary Angiographic Analyses. JACC Cardiovascular Imaging 2012, 5: s1-s9. PMID: 22421222, DOI: 10.1016/j.jcmg.2011.11.019.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryCoronary AngiographyCoronary Artery DiseaseCoronary StenosisDisease ProgressionEuropeFemaleFibrosisHumansImage Processing, Computer-AssistedMaleMiddle AgedMultivariate AnalysisNeointimaPredictive Value of TestsProspective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexTerminology as TopicTime FactorsTreatment OutcomeUltrasonography, InterventionalUnited StatesVascular CalcificationConceptsThin-cap fibroatheromaAdverse cardiovascular eventsRadiofrequency intravascular ultrasoundNatural history studiesNonculprit lesionsPlaque burdenCardiovascular eventsLuminal areaIntravascular ultrasoundVH thin-cap fibroatheromaMajor adverse cardiovascular eventsFuture adverse cardiovascular eventsCoronary angiographic analysisCoronary artery ostiumThick-cap fibroatheromaLarger plaque burdenVirtual histologyMinimal luminal areaPathological intimal thickeningSmall luminal areaCoronary artery imagingHistory studiesSide branchesCoronary atherosclerosisCulprit lesionCoronary Plaque Composition, Morphology, and Outcomes in Patients With and Without Chronic Kidney Disease Presenting With Acute Coronary Syndromes
Baber U, Stone GW, Weisz G, Moreno P, Dangas G, Maehara A, Mintz GS, Cristea E, Fahy M, Xu K, Lansky AJ, Wennerblom B, Mathey DG, Templin B, Zhang Z, Serruys PW, Mehran R. Coronary Plaque Composition, Morphology, and Outcomes in Patients With and Without Chronic Kidney Disease Presenting With Acute Coronary Syndromes. JACC Cardiovascular Imaging 2012, 5: s53-s61. PMID: 22421231, DOI: 10.1016/j.jcmg.2011.12.008.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAngina, UnstableAngioplasty, Balloon, CoronaryChronic DiseaseCoronary AngiographyCoronary Artery DiseaseEuropeFemaleFibrosisHeart ArrestHumansKaplan-Meier EstimateKidney DiseasesMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionNecrosisPlaque, AtheroscleroticPredictive Value of TestsProspective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexTime FactorsTreatment OutcomeUltrasonography, InterventionalUnited StatesVascular CalcificationConceptsAcute coronary syndromeChronic kidney diseasePercutaneous coronary interventionCoronary plaque compositionNonculprit lesionsPlaque compositionCoronary syndromeAdverse eventsCoronary interventionCardiac deathKidney diseaseMyocardial infarctionNecrotic coreFibrous tissueGreater necrotic coreUntreated nonculprit lesionsRadiofrequency intravascular ultrasoundCoronary atherosclerotic plaque compositionMinimal luminal areaPercentage of plaqueLesion-level analysisIntravascular ultrasound parametersAtherosclerotic plaque compositionCKD patientsCulprit lesion