2022
Angiographic Lesion Discordance in Women Presenting With Ischemic Heart Disease: Comparison of Visual Assessment, Quantitative Coronary Angiography, and Quantitative Flow Ratio.
Gitto M, Saito Y, Taoutel R, Schneider MD, Papoutsidakis N, Ardito S, Henry G, Cristea E, Lansky AJ, Altin SE. Angiographic Lesion Discordance in Women Presenting With Ischemic Heart Disease: Comparison of Visual Assessment, Quantitative Coronary Angiography, and Quantitative Flow Ratio. Journal Of Invasive Cardiology 2022, 34: e202-e209. PMID: 35089162, DOI: 10.25270/jic/21.00146.Peer-Reviewed Original ResearchConceptsQuantitative coronary angiographyIschemic heart diseaseQuantitative flow ratioStress perfusion imagingDiameter stenosisCoronary angiographyIschemic symptomsCoronary revascularizationHeart diseasePerfusion imagingStenosis severityIndependent core laboratoryCohort of womenVisual assessmentCoronary stenosis severityConsecutive patientsAngiographic severityCoronary stenosisLesion assessmentClinical practiceCore laboratoryLesionsAngiographyWomenBlinded operators
2020
TCT CONNECT-208 Accuracy of Quantitative Coronary Angiography and Visual Assessment for Predicting Functionally Significant Stenoses in Women With Chronic Coronary Syndrome
Gitto M, Taoutel R, Schneider M, Papoutsidakis N, Ardito S, Cristea E, Lansky A, Altin S. TCT CONNECT-208 Accuracy of Quantitative Coronary Angiography and Visual Assessment for Predicting Functionally Significant Stenoses in Women With Chronic Coronary Syndrome. Journal Of The American College Of Cardiology 2020, 76: b88. DOI: 10.1016/j.jacc.2020.09.223.Peer-Reviewed Original ResearchChronic coronary syndromeQuantitative coronary angiographyCoronary syndromeCoronary angiographySignificant stenosisVisual assessmentStenosisAngiographySyndromeWomenShear Stress Estimated by Quantitative Coronary Angiography Predicts Plaques Prone to Progress and Cause Events
Bourantas CV, Zanchin T, Torii R, Serruys PW, Karagiannis A, Ramasamy A, Safi H, Coskun AU, Koning G, Onuma Y, Zanchin C, Krams R, Mathur A, Baumbach A, Mintz G, Windecker S, Lansky A, Maehara A, Stone PH, Raber L, Stone GW. Shear Stress Estimated by Quantitative Coronary Angiography Predicts Plaques Prone to Progress and Cause Events. JACC Cardiovascular Imaging 2020, 13: 2206-2219. PMID: 32417338, DOI: 10.1016/j.jcmg.2020.02.028.Peer-Reviewed Original ResearchConceptsHigh endothelial shear stressEndothelial shear stressLipid-rich plaquesPlaque burdenCardiovascular eventsPlaque characteristicsMajor adverse cardiovascular eventsSmaller minimum lumen areaLow endothelial shear stressHigh-risk anatomyAdverse cardiovascular eventsUseful prognostic informationQuantitative coronary angiographyMinimum lumen areaPrediction of lesionsLipid-rich lesionsESS valuesCoronary angiographyIndependent predictorsMultivariable analysisHemodynamic variablesPrognostic valueVH-IVUSHemodynamic indicesPrognostic informationPredictive value of the QFR in detecting vulnerable plaques in non-flow limiting lesions: a combined analysis of the PROSPECT and IBIS-4 study
Safi H, Bourantas CV, Ramasamy A, Zanchin T, Bär S, Tufaro V, Jin C, Torii R, Karagiannis A, Reiber JHC, Mathur A, Onuma Y, Windecker S, Lansky A, Maehara A, Serruys PW, Stone P, Baumbach A, Stone GW, Räber L. Predictive value of the QFR in detecting vulnerable plaques in non-flow limiting lesions: a combined analysis of the PROSPECT and IBIS-4 study. The International Journal Of Cardiovascular Imaging 2020, 36: 993-1002. PMID: 32152810, DOI: 10.1007/s10554-020-01805-9.Peer-Reviewed Original ResearchMeSH KeywordsAgedCoronary AngiographyCoronary Artery DiseaseCoronary CirculationCoronary VesselsDisease ProgressionFemaleHumansMaleMiddle AgedPlaque, AtheroscleroticPredictive Value of TestsPrognosisRadiographic Image Interpretation, Computer-AssistedRetrospective StudiesRupture, SpontaneousSeverity of Illness IndexTime FactorsUltrasonography, InterventionalConceptsVirtual histology intravascular ultrasoundQuantitative flow ratioMinimum lumen diameterMinimum lumen areaCoronary angiographyPlaque burdenIBIS-4 studyPrognostic informationVulnerable plaquesSmaller minimum lumen areaMajor adverse cardiac eventsVulnerable phenotypeAdverse cardiac eventsGreater plaque burdenPredictors of MACENon-culprit lesionsAdditional prognostic informationSmaller minimum lumen diameterUseful prognostic informationQuantitative coronary angiographyAdditive valueCardiac eventsPlaque characteristicsLesion severityAngiographic dataQUANTITATIVE FLOW RATIO ACCORDING TO THREE-DIMENSIONAL QUANTITATIVE CORONARY ANGIOGRAPHY DEFINED SEVERITY OF STENOSIS IN A COHORT OF WOMEN WITH STABLE CORONARY ARTERY DISEASE
Gitto M, Saito Y, Schneider M, Papoutsidakis N, Ardito S, McCarthy M, Cristea E, Lansky A, Altin S. QUANTITATIVE FLOW RATIO ACCORDING TO THREE-DIMENSIONAL QUANTITATIVE CORONARY ANGIOGRAPHY DEFINED SEVERITY OF STENOSIS IN A COHORT OF WOMEN WITH STABLE CORONARY ARTERY DISEASE. Journal Of The American College Of Cardiology 2020, 75: 177. DOI: 10.1016/s0735-1097(20)30804-4.Peer-Reviewed Original ResearchDISCREPANCY BETWEEN VISUALLY ASSESSED AND QUANTITATIVE CORONARY ANGIOGRAPHY DERIVED DIAMETER STENOSIS IN A COHORT OF WOMEN WITH STABLE CORONARY ARTERY DISEASE
Gitto M, Saito Y, Schneider M, Papoutsidakis N, Ardito S, McCarthy M, Cristea E, Lansky A, Altin S. DISCREPANCY BETWEEN VISUALLY ASSESSED AND QUANTITATIVE CORONARY ANGIOGRAPHY DERIVED DIAMETER STENOSIS IN A COHORT OF WOMEN WITH STABLE CORONARY ARTERY DISEASE. Journal Of The American College Of Cardiology 2020, 75: 178. DOI: 10.1016/s0735-1097(20)30805-6.Peer-Reviewed Original Research
2019
P869Predictive value of the endothelial shear stress distribution in three-dimensional quantitative coronary angiography models in detecting vulnerable plaques
Zanchin T, Bourantas C, Torii R, Serruys P, Karagiannis A, Ramasamy A, Onuma Y, Mathur A, Baumbach A, Windecker S, Lansky A, Maehara A, Stone P, Raeber L, Stone G. P869Predictive value of the endothelial shear stress distribution in three-dimensional quantitative coronary angiography models in detecting vulnerable plaques. European Heart Journal 2019, 40: ehz747.0466. DOI: 10.1093/eurheartj/ehz747.0466.Peer-Reviewed Original ResearchHigh endothelial shear stressEndothelial shear stressLow endothelial shear stressQuantitative coronary angiographyMinimum lumen areaPd/PaVulnerable plaquesPlaque burdenSmaller minimum lumen areaMajor adverse cardiac eventsLarge-scale prospective studiesBaseline plaque characteristicsHigh-risk anatomyAdverse cardiac eventsNon-culprit lesionsOnly independent predictorUseful prognostic informationHigh-risk plaquesESS valuesNC-MACECardiac eventsCoronary atherosclerosisCoronary angiographyIndependent predictorsMultivariable analysis
2018
Comparison of Physician Visual Assessment With Quantitative Coronary Angiography in Assessment of Stenosis Severity in China
Zhang H, Mu L, Hu S, Nallamothu BK, Lansky AJ, Xu B, Bouras G, Cohen DJ, Spertus JA, Masoudi FA, Curtis JP, Gao R, Ge J, Yang Y, Li J, Li X, Zheng X, Li Y, Krumholz HM, Jiang L. Comparison of Physician Visual Assessment With Quantitative Coronary Angiography in Assessment of Stenosis Severity in China. JAMA Internal Medicine 2018, 178: 239-247. PMID: 29340571, PMCID: PMC5838612, DOI: 10.1001/jamainternmed.2017.7821.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overChinaCoronary AngiographyCoronary StenosisCoronary VesselsCross-Sectional StudiesFemaleFollow-Up StudiesHumansIncidenceMaleMiddle AgedPercutaneous Coronary InterventionPractice Patterns, Physicians'Predictive Value of TestsProspective StudiesRisk AssessmentSeverity of Illness IndexTime FactorsConceptsPhysician visual assessmentPercutaneous coronary interventionAcute myocardial infarctionQuantitative coronary angiographyStenosis severityCoronary angiographyMean agePCI studiesMean percent diameter stenosisIndependent core laboratoryPercent diameter stenosisCross-sectional studyNon-AMI patientsStandard clinical practiceFractional flow reserveSubset of participantsQCA assessmentCoronary revascularizationMore stenosisCoronary interventionCoronary lesionsChina PatientCoronary angiogramDiameter stenosisMyocardial infarction
2016
Diagnostic Accuracy of Fast Computational Approaches to Derive Fractional Flow Reserve From Diagnostic Coronary Angiography The International Multicenter FAVOR Pilot Study
Tu S, Westra J, Yang J, von Birgelen C, Ferrara A, Pellicano M, Nef H, Tebaldi M, Murasato Y, Lansky A, Barbato E, van der Heijden LC, Reiber JH, Holm NR, Wijns W, Group F. Diagnostic Accuracy of Fast Computational Approaches to Derive Fractional Flow Reserve From Diagnostic Coronary Angiography The International Multicenter FAVOR Pilot Study. JACC Cardiovascular Interventions 2016, 9: 2024-2035. PMID: 27712739, DOI: 10.1016/j.jcin.2016.07.013.Peer-Reviewed Original ResearchMeSH KeywordsAdenosineAdministration, IntravenousAgedArea Under CurveBlood Flow VelocityCardiac CatheterizationChinaComputer SimulationCoronary AngiographyCoronary StenosisCoronary VesselsEuropeFeasibility StudiesFemaleFractional Flow Reserve, MyocardialHumansHyperemiaJapanMaleMiddle AgedModels, CardiovascularMyocardial Perfusion ImagingPilot ProjectsPredictive Value of TestsPrognosisProspective StudiesRadiographic Image Interpretation, Computer-AssistedRegional Blood FlowReproducibility of ResultsROC CurveSeverity of Illness IndexTime FactorsUnited StatesVasodilator AgentsWorkflowConceptsQuantitative flow ratioHyperemic flow velocityReceiver-operating characteristic curveCoronary angiographyDiagnostic accuracyAngiographic percent diameter stenosisDiagnostic coronary angiographyProspective multicenter studyIndependent core laboratoryAdenosine-induced hyperemiaPercent diameter stenosisQuantitative coronary angiographyIntermediate coronary lesionsCharacteristic curveFractional flow reservePositive likelihood ratioOverall diagnostic accuracyNegative likelihood ratioDrug-induced hyperemiaLikelihood ratioCoronary lesionsMulticenter studyDiameter stenosisMaximal hyperemiaFlow reserve
2015
Bioabsorbable polymer‐coated sirolimus‐eluting stent implantation preserves coronary vasomotion: A DESSOLVE II trial sub‐study
Rusinaru D, Vrolix M, Verheye S, Chowdhary S, Schoors D, Di Mario C, Desmet W, Donohoe DJ, Ormiston JA, Knape C, Bezerra H, Lansky A, Wijns W, Investigators O. Bioabsorbable polymer‐coated sirolimus‐eluting stent implantation preserves coronary vasomotion: A DESSOLVE II trial sub‐study. Catheterization And Cardiovascular Interventions 2015, 86: 1141-1150. PMID: 25044635, DOI: 10.1002/ccd.25610.Peer-Reviewed Original ResearchMeSH KeywordsAbsorbable ImplantsAgedCardiac Pacing, ArtificialCardiovascular AgentsCoronary AngiographyCoronary Artery DiseaseCoronary VesselsDrug-Eluting StentsEuropeFemaleHistorically Controlled StudyHumansMaleMiddle AgedNew ZealandPercutaneous Coronary InterventionPolymersProspective StudiesSingle-Blind MethodSirolimusTime FactorsTreatment OutcomeVasoconstrictionVasodilationConceptsZotarolimus-eluting stentsDrug-eluting stentsCoronary vasomotionII trialVasomotor dysfunctionFirst-generation drug-eluting stentsEndeavor zotarolimus-eluting stentsGeneration drug-eluting stentsCoronary vasomotor dysfunctionSirolimus-eluting stentsQuantitative coronary angiographyVessel diameterMaximal pacingCoronary angiographyZES groupCoronary arteryVasomotor responsesHistorical groupStent edgeNormal vasomotionPatientsPercent changeReference segmentsVasomotionSES groupRandomised study of a bioabsorbable polymer-coated sirolimus-eluting stent: results of the DESSOLVE II trial.
Wijns W, Vrolix M, Verheye S, Schoors D, Slagboom T, Gosselink M, Benit E, Donohoe D, Knape C, Attizzani GF, Lansky AJ, Ormiston J. Randomised study of a bioabsorbable polymer-coated sirolimus-eluting stent: results of the DESSOLVE II trial. EuroIntervention 2015, 10: 1383-90. PMID: 24801119, DOI: 10.4244/eijy14m05_03.Peer-Reviewed Original ResearchConceptsZotarolimus-eluting stentsLate lumen lossStent late lumen lossOptical coherence tomographyII trialMajor adverse cardiac eventsMean late lumen lossClinical safety endpointPrimary efficacy hypothesisAdverse cardiac eventsPrimary efficacy endpointStent thrombosis ratesMean neointimal thicknessSirolimus-eluting stentsQuantitative coronary angiographyZES patientsEfficacy endpointPrimary endpointSafety endpointVolume obstructionCardiac eventsCoronary angiographyThrombosis rateZES groupStrut coverage
2013
Response to Letters Regarding Article, “Comparison of Clinical Interpretation With Visual Assessment and Quantitative Coronary Angiography in Patients Undergoing Percutaneous Coronary Intervention in Contemporary Practice
Nallamothu BK, Spertus JA, Lansky AJ, Cohen DJ, Jones PG, Kureshi F, Dehmer GJ, Drozda JP, Walsh MN, Brush JE, Koenig GC, Waites TF, Gantt DS, Kichura G, Chazal RA, O’Brien P, Valentine CM, Rumsfeld JS, Reiber JH, Elmore JG, Krumholz RA, Weaver WD, Krumholz HM. Response to Letters Regarding Article, “Comparison of Clinical Interpretation With Visual Assessment and Quantitative Coronary Angiography in Patients Undergoing Percutaneous Coronary Intervention in Contemporary Practice. Circulation 2013, 128: e463-e464. PMID: 24344070, PMCID: PMC8698215, DOI: 10.1161/circulationaha.113.005507.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionQuantitative coronary angiographyCoronary interventionCoronary angiographyClinical interpretationVisual assessmentPatientsAngiographyA composite peripheral blood gene expression score has high sensitivity for obstructive coronary artery disease in a non-invasive imaging population and correlates with plaque burden and morphology by
Voros S, Thomas G, Bateman T, Mcpherson J, Lansky A, Douglas P, Ladapo J, Wingrove J, Elashoff M, Rosenberg S. A composite peripheral blood gene expression score has high sensitivity for obstructive coronary artery disease in a non-invasive imaging population and correlates with plaque burden and morphology by. European Heart Journal 2013, 34: p2413. DOI: 10.1093/eurheartj/eht308.p2413.Peer-Reviewed Original ResearchMyocardial perfusion imagingNon-calcified plaquePlaque burdenInvasive angiogramObstructive coronary artery diseaseQuantitative CTA analysisNon-diabetic patientsCoronary artery diseaseOverall plaque burdenQuantitative coronary angiographyNegative predictive valueGene expression scoreNeutrophil upregulationArtery diseaseCalcium scoreCoronary angiographyInvasive angiographyGES scoresCAD casesBlood samplesCTA analysisPatientsPerfusion imagingReferral pathsPredictive valueComparison of Clinical Interpretation With Visual Assessment and Quantitative Coronary Angiography in Patients Undergoing Percutaneous Coronary Intervention in Contemporary Practice
Nallamothu BK, Spertus JA, Lansky AJ, Cohen DJ, Jones PG, Kureshi F, Dehmer GJ, Drozda JP, Walsh MN, Brush JE, Koenig GC, Waites TF, Gantt DS, Kichura G, Chazal RA, O’Brien P, Valentine CM, Rumsfeld JS, Reiber JH, Elmore JG, Krumholz RA, Weaver WD, Krumholz HM. Comparison of Clinical Interpretation With Visual Assessment and Quantitative Coronary Angiography in Patients Undergoing Percutaneous Coronary Intervention in Contemporary Practice. Circulation 2013, 127: 1793-1800. PMID: 23470859, PMCID: PMC3908681, DOI: 10.1161/circulationaha.113.001952.Peer-Reviewed Original ResearchConceptsQuantitative coronary angiographyPercent diameter stenosisPercutaneous coronary interventionDiameter stenosisCoronary interventionCoronary angiographyCoronary lesionsClinical interpretationAngiographic interpretationStenosis severityHigher percent diameter stenosisMedian percent diameter stenosisElective percutaneous coronary interventionMean differenceCoronary stenosis severityIntermediate lesionsUS hospitalsStenosisLesionsAngiographyPatientsInterventionSeverityVisual assessmentSuch findings
2012
Long-Term Prognosis of Patients Presenting With ST-Segment Elevation Myocardial Infarction With No Significant Coronary Artery Disease (from The HORIZONS-AMI Trial)
Larsen AI, Nilsen DW, Yu J, Mehran R, Nikolsky E, Lansky AJ, Caixeta A, Parise H, Fahy M, Cristea E, Witzenbichler B, Guagliumi G, Peruga JZ, Brodie BR, Dudek D, Stone GW. Long-Term Prognosis of Patients Presenting With ST-Segment Elevation Myocardial Infarction With No Significant Coronary Artery Disease (from The HORIZONS-AMI Trial). The American Journal Of Cardiology 2012, 111: 643-648. PMID: 23261001, DOI: 10.1016/j.amjcard.2012.11.011.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionSignificant coronary artery diseaseCoronary artery diseaseElevation myocardial infarctionArtery diseaseMyocardial infarctionGreater left ventricular ejection fractionMajor adverse cardiovascular eventsNet adverse clinical eventsAcute Myocardial Infarction trialObstructive coronary artery diseaseLeft ventricular ejection fractionLower body mass indexBaseline coronary angiogramAdverse cardiovascular eventsCoronary artery bypassMyocardial Infarction trialNormal coronary arteriesOutcomes of patientsAdverse clinical eventsPrognosis of patientsVentricular ejection fractionBody mass indexQuantitative coronary angiographyRate of deathA gender-specific blood-based gene expression score for assessing obstructive coronary artery disease in nondiabetic patients: Results of the Personalized Risk Evaluation and Diagnosis in the Coronary Tree (PREDICT) Trial
Lansky A, Elashoff MR, Ng V, McPherson J, Lazar D, Kraus WE, Voros S, Schwartz RS, Topol EJ. A gender-specific blood-based gene expression score for assessing obstructive coronary artery disease in nondiabetic patients: Results of the Personalized Risk Evaluation and Diagnosis in the Coronary Tree (PREDICT) Trial. American Heart Journal 2012, 164: 320-326. PMID: 22980297, DOI: 10.1016/j.ahj.2012.05.012.Peer-Reviewed Original ResearchConceptsObstructive coronary artery diseaseCoronary artery diseaseMyocardial perfusion imagingGene expression scoreQuantitative coronary angiographyExpression scoreNondiabetic patientsArtery diseaseCardiac catheterizationCoronary angiographyBurden of CADSeverity of CADNoninvasive myocardial perfusion imagingProspective multicenter observational studyUnknown coronary artery diseaseSignificant coronary artery diseaseDiagnostic approachUnnecessary cardiac catheterizationMulticenter observational studyChest pain symptomsDiagnostic cardiac catheterizationAvailable noninvasive testsNoninvasive test resultsPositive predictive valueReliable diagnostic approachUsefulness of Noninvasive Fractional Flow Reserve Computed from Coronary Computed Tomographic Angiograms for Intermediate Stenoses Confirmed by Quantitative Coronary Angiography
Min JK, Koo BK, Erglis A, Doh JH, Daniels DV, Jegere S, Kim HS, Dunning AM, DeFrance T, Lansky A, Leipsic J. Usefulness of Noninvasive Fractional Flow Reserve Computed from Coronary Computed Tomographic Angiograms for Intermediate Stenoses Confirmed by Quantitative Coronary Angiography. The American Journal Of Cardiology 2012, 110: 971-976. PMID: 22749390, DOI: 10.1016/j.amjcard.2012.05.033.Peer-Reviewed Original ResearchConceptsLesion-specific ischemiaFractional flow reserveCoronary lesionsIntermediate stenosisFlow reservePredictive valueNoninvasive methodComputed Tomographic AngiogramsCoronary computed tomographyNoninvasive fractional flow reserveQuantitative coronary angiographyReceiver operator characteristic curveIntermediate stenosis severityNegative predictive valuePositive predictive valueOperator characteristic curveCoronary angiographyInvasive angiographyMean ageTomographic angiogramBland-Altman analysisStudy groupIschemiaComputed tomographyNovel noninvasive methodBifurcation Quantitative Coronary Angiography
Ng V, Lansky A. Bifurcation Quantitative Coronary Angiography. 2012, 121-135. DOI: 10.1002/9781444347005.ch13.Peer-Reviewed Original ResearchFirst report of a novel abluminal groove filled biodegradable polymer rapamycin-eluting stent in de novo coronary artery disease: results of the first in man FIREHAWK trial.
Qian J, Xu B, Lansky AJ, Yang YJ, Qiao SB, Wu YJ, Chen J, Hu FH, Yang WX, Mintz GS, Leon MB, Gao RL. First report of a novel abluminal groove filled biodegradable polymer rapamycin-eluting stent in de novo coronary artery disease: results of the first in man FIREHAWK trial. Chinese Medical Journal 2012, 125: 970-6. PMID: 22613516.Peer-Reviewed Original ResearchConceptsMajor adverse cardiac eventsQuantitative coronary angiographyDrug-eluting stentsAbluminal grooveMyocardial infarctionDe novo coronary artery diseaseDe novo native coronary stenosisIschemia-driven target lesion revascularizationNovo coronary artery diseaseStent late lumen lossFirst-generation drug-eluting stentsComplete strut coverageAdverse cardiac eventsTarget lesion revascularizationTarget vessel revascularizationClinical success rateCoronary artery diseaseLate lumen lossNative coronary stenosisPrior myocardial infarctionStent late lossLate DES thrombosisLong-term restenosisLesion revascularizationPrimary endpointPlaque Composition and Clinical Outcomes in Acute Coronary Syndrome Patients With Metabolic Syndrome or Diabetes
Marso SP, Mercado N, Maehara A, Weisz G, Mintz GS, McPherson J, Schiele F, Dudek D, Fahy M, Xu K, Lansky A, Templin B, Zhang Z, de Bruyne B, Serruys PW, Stone GW. Plaque Composition and Clinical Outcomes in Acute Coronary Syndrome Patients With Metabolic Syndrome or Diabetes. JACC Cardiovascular Imaging 2012, 5: s42-s52. PMID: 22421230, DOI: 10.1016/j.jcmg.2012.01.008.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAngina, UnstableAngioplasty, Balloon, CoronaryChi-Square DistributionCoronary AngiographyCoronary Artery DiseaseCoronary StenosisDiabetes MellitusEuropeFemaleHeart ArrestHumansKaplan-Meier EstimateMaleMetabolic SyndromeMiddle AgedMultivariate AnalysisMyocardial InfarctionNecrosisPlaque, AtheroscleroticPredictive Value of TestsProportional Hazards ModelsProspective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexTime FactorsTomography, X-Ray ComputedTreatment OutcomeUltrasonography, InterventionalUnited StatesVascular CalcificationConceptsMajor adverse cardiac eventsGreater necrotic coreUntreated nonculprit lesionsAcute coronary syndromeMet SynNonculprit lesionsPercutaneous coronary interventionSYN patientsNecrotic coreMACE rateMetabolic syndromePlaque burdenFuture major adverse cardiac eventsSubsequent major adverse cardiac eventsAcute coronary syndrome patientsSuccessful percutaneous coronary interventionGreater plaque burdenAdverse cardiac eventsCoronary syndrome patientsHigh-risk groupQuantitative coronary angiographySmaller lumen areaACS patientsCoronary syndromeACS population