2019
The Clinical Utility of a Precision Medicine Blood Test Incorporating Age, Sex, and Gene Expression for Evaluating Women with Stable Symptoms Suggestive of Obstructive Coronary Artery Disease: Analysis from the PRESET Registry
Gul B, Lansky A, Budoff MJ, Sharp D, Maniet B, Herman L, Kuo JZ, Huang L, Monane M, Ladapo JA. The Clinical Utility of a Precision Medicine Blood Test Incorporating Age, Sex, and Gene Expression for Evaluating Women with Stable Symptoms Suggestive of Obstructive Coronary Artery Disease: Analysis from the PRESET Registry. Journal Of Women's Health 2019, 28: 728-735. PMID: 30653377, PMCID: PMC6537117, DOI: 10.1089/jwh.2018.7203.Peer-Reviewed Original ResearchConceptsObstructive coronary artery diseaseCoronary artery diseaseFurther cardiac evaluationCardiac evaluationArtery diseaseClinical utilityStable obstructive coronary artery diseaseMajor adverse cardiac eventsMedian age 57 yearsMedian body mass indexAdverse cardiac eventsAge 57 yearsManagement of womenBody mass indexCommunity-based registryPrimary care practicesPrecision medicine testsGene expression scoreCardiac referralHypertension presentSymptoms SuggestiveCardiac eventsClinical characteristicsMass indexStudy cohort
2013
A composite peripheral blood gene expression score has high sensitivity for obstructive coronary artery disease in a non-invasive imaging population and correlates with plaque burden and morphology by
Voros S, Thomas G, Bateman T, Mcpherson J, Lansky A, Douglas P, Ladapo J, Wingrove J, Elashoff M, Rosenberg S. A composite peripheral blood gene expression score has high sensitivity for obstructive coronary artery disease in a non-invasive imaging population and correlates with plaque burden and morphology by. European Heart Journal 2013, 34: p2413. DOI: 10.1093/eurheartj/eht308.p2413.Peer-Reviewed Original ResearchMyocardial perfusion imagingNon-calcified plaquePlaque burdenInvasive angiogramObstructive coronary artery diseaseQuantitative CTA analysisNon-diabetic patientsCoronary artery diseaseOverall plaque burdenQuantitative coronary angiographyNegative predictive valueGene expression scoreNeutrophil upregulationArtery diseaseCalcium scoreCoronary angiographyInvasive angiographyGES scoresCAD casesBlood samplesCTA analysisPatientsPerfusion imagingReferral pathsPredictive valueA Blood-Based Gene Expression Test for Obstructive Coronary Artery Disease Tested in Symptomatic Nondiabetic Patients Referred for Myocardial Perfusion Imaging The COMPASS Study
Thomas GS, Voros S, McPherson JA, Lansky AJ, Winn ME, Bateman TM, Elashoff MR, Lieu HD, Johnson AM, Daniels SE, Ladapo JA, Phelps CE, Douglas PS, Rosenberg S. A Blood-Based Gene Expression Test for Obstructive Coronary Artery Disease Tested in Symptomatic Nondiabetic Patients Referred for Myocardial Perfusion Imaging The COMPASS Study. Circulation Genomic And Precision Medicine 2013, 6: 154-162. PMID: 23418288, DOI: 10.1161/circgenetics.112.964015.Peer-Reviewed Original ResearchConceptsMyocardial perfusion imagingInvasive coronary angiographyGene expression scoreCoronary angiographyNegative predictive valueNondiabetic patientsSymptomatic patientsClinical factorsPredictive valuePrespecified primary end pointObstructive coronary artery diseaseAbnormal myocardial perfusion imagingBlood-based gene expression testAdverse cardiovascular eventsPrimary end pointCoronary artery diseaseReceiver-operating characteristic curvePeripheral blood samplesReceiver-operating characteristic analysisCoronary artery disease diagnosisMaximum percent stenosisGene expression testReceiver-operating characteristicCardiovascular eventsArtery disease
2012
A gender-specific blood-based gene expression score for assessing obstructive coronary artery disease in nondiabetic patients: Results of the Personalized Risk Evaluation and Diagnosis in the Coronary Tree (PREDICT) Trial
Lansky A, Elashoff MR, Ng V, McPherson J, Lazar D, Kraus WE, Voros S, Schwartz RS, Topol EJ. A gender-specific blood-based gene expression score for assessing obstructive coronary artery disease in nondiabetic patients: Results of the Personalized Risk Evaluation and Diagnosis in the Coronary Tree (PREDICT) Trial. American Heart Journal 2012, 164: 320-326. PMID: 22980297, DOI: 10.1016/j.ahj.2012.05.012.Peer-Reviewed Original ResearchConceptsObstructive coronary artery diseaseCoronary artery diseaseMyocardial perfusion imagingGene expression scoreQuantitative coronary angiographyExpression scoreNondiabetic patientsArtery diseaseCardiac catheterizationCoronary angiographyBurden of CADSeverity of CADNoninvasive myocardial perfusion imagingProspective multicenter observational studyUnknown coronary artery diseaseSignificant coronary artery diseaseDiagnostic approachUnnecessary cardiac catheterizationMulticenter observational studyChest pain symptomsDiagnostic cardiac catheterizationAvailable noninvasive testsNoninvasive test resultsPositive predictive valueReliable diagnostic approachWhole Blood Gene Expression Testing for Coronary Artery Disease in Nondiabetic Patients: Major Adverse Cardiovascular Events and Interventions in the PREDICT Trial
Rosenberg S, Elashoff MR, Lieu HD, Brown BO, Kraus WE, Schwartz RS, Voros S, Ellis SG, Waksman R, McPherson JA, Lansky AJ, Topol EJ, for the PREDICT Investigators. Whole Blood Gene Expression Testing for Coronary Artery Disease in Nondiabetic Patients: Major Adverse Cardiovascular Events and Interventions in the PREDICT Trial. Journal Of Cardiovascular Translational Research 2012, 5: 366-374. PMID: 22396313, PMCID: PMC3349850, DOI: 10.1007/s12265-012-9353-z.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAngioplasty, Balloon, CoronaryCoronary AngiographyCoronary Artery BypassCoronary Artery DiseaseFemaleGene Expression RegulationGenetic Predisposition to DiseaseGenetic TestingHumansIschemic Attack, TransientLogistic ModelsMaleMiddle AgedMyocardial InfarctionOdds RatioPhenotypePredictive Value of TestsPrognosisProspective StudiesReproducibility of ResultsRisk AssessmentRisk FactorsStrokeTime FactorsUnited StatesConceptsMajor adverse cardiovascular eventsCoronary artery diseaseObstructive coronary artery diseaseGene expression scoreAdverse cardiovascular eventsCardiovascular eventsArtery diseaseClinical risk scoreGroup of patientsNegative predictive valueGene expression testingNondiabetic patientsPREDICT trialAngiography patientsGES groupPREDICT studyRisk scorePatientsPredictive valueExpression scoreRevascularizationEvent ratesDiseaseMonthsExpression testingA PREVIOUSLY VALIDATED PERIPHERAL GENE EXPRESSION SCORE IS MOSTLY DETERMINED BY NON-CALCIFIED PLAQUE AND LUMINAL STENOSIS AS ASSESSED BY QUANTITATIVE, 3-DIMENSIONAL MEASUREMENTS BY CT ANGIOGRAPHY IN THE MULTI-CENTER, PROSPECTIVE COMPASS STUDY
Voros S, Thomas G, Lansky A, McPherson J, Elashoff M, Rinehart S, Johnson A, Rosenberg S. A PREVIOUSLY VALIDATED PERIPHERAL GENE EXPRESSION SCORE IS MOSTLY DETERMINED BY NON-CALCIFIED PLAQUE AND LUMINAL STENOSIS AS ASSESSED BY QUANTITATIVE, 3-DIMENSIONAL MEASUREMENTS BY CT ANGIOGRAPHY IN THE MULTI-CENTER, PROSPECTIVE COMPASS STUDY. Journal Of The American College Of Cardiology 2012, 59: e1370. DOI: 10.1016/s0735-1097(12)61371-0.Peer-Reviewed Original ResearchA PERIPHERAL BLOOD GENE EXPRESSION SCORE FOR CORONARY ARTERY DISEASE IN NON-DIABETIC PATIENTS IDENTIFIES PATIENTS AT LOW RISK FOR MAJOR CARDIOVASCULAR EVENTS AND INTERVENTIONAL PROCEDURES IN THE NEXT 12 MONTHS
Kraus W, Voros S, Schwartz R, Ellis S, Waksman R, Tahirkheli N, Lieu H, Elashoff M, Rosenberg S, McPherson J, Lansky A, Topol E. A PERIPHERAL BLOOD GENE EXPRESSION SCORE FOR CORONARY ARTERY DISEASE IN NON-DIABETIC PATIENTS IDENTIFIES PATIENTS AT LOW RISK FOR MAJOR CARDIOVASCULAR EVENTS AND INTERVENTIONAL PROCEDURES IN THE NEXT 12 MONTHS. Journal Of The American College Of Cardiology 2012, 59: e1383. DOI: 10.1016/s0735-1097(12)61384-9.Peer-Reviewed Original Research