2024
Illusion of revascularization: does anyone achieve optimal revascularization during percutaneous coronary intervention?
Fezzi S, Ding D, Mahfoud F, Huang J, Lansky A, Tu S, Wijns W. Illusion of revascularization: does anyone achieve optimal revascularization during percutaneous coronary intervention? Nature Reviews Cardiology 2024, 21: 652-662. PMID: 38710772, DOI: 10.1038/s41569-024-01014-0.Peer-Reviewed Original ResearchPercutaneous coronary interventionOptimal revascularizationRisk of periprocedural myocardial infarctionCoronary interventionMyocardial infarctionStent-related eventsEfficacy of percutaneous coronary interventionCoronary artery diseasePeriprocedural myocardial infarctionAcute myocardial infarctionReperfusion of acute myocardial infarctionClinical successRevascularization outcomesArtery diseaseIncreased riskAngiographic guidancePercutaneous revascularizationRevascularizationPatientsIntracoronary imagingLincoffDiagnostic toolPhysiological assessmentAngiographic Characteristics and Clinical Outcomes in Patients With Chronic Kidney Disease Undergoing Impella-Supported High-Risk Percutaneous Coronary Intervention: Insights From the cVAD PROTECT III Study
Bharadwaj A, Abu-Much A, Maini A, Zhou Z, Li Y, Batchelor W, Grines C, Baron S, Redfors B, Lansky A, Basir M, O’Neill W. Angiographic Characteristics and Clinical Outcomes in Patients With Chronic Kidney Disease Undergoing Impella-Supported High-Risk Percutaneous Coronary Intervention: Insights From the cVAD PROTECT III Study. Circulation Cardiovascular Interventions 2024, 17: e013503. PMID: 38708609, PMCID: PMC11239095, DOI: 10.1161/circinterventions.123.013503.Peer-Reviewed Original ResearchChronic kidney diseaseHigh-risk percutaneous coronary interventionPercutaneous coronary interventionAdvanced chronic kidney diseaseIII studiesCerebrovascular eventsAngiographic characteristicsClinical outcomesCoronary calcificationCoronary interventionSevere coronary calcificationCardiac Surgery scoreHigh-risk patientsLong-term outcomesPercutaneous coronary intervention complicationsPCI-related complicationsPrevalence of hypertensionPeripheral arterial diseaseCoronary complicationsBaseline comorbiditiesSurgery scoreArtery diseasePrimary outcomeEGFRKidney diseaseAssociation of Preprocedural SYNTAX Score With Outcomes in Impella-Assisted High-Risk Percutaneous Coronary Intervention
Medranda G, Faraz H, Thompson J, Zhang Y, Bharadwaj A, Osborn E, Abu-Much A, Lansky A, Basir M, Moses J, O’Neill W, Grines C, Baron S. Association of Preprocedural SYNTAX Score With Outcomes in Impella-Assisted High-Risk Percutaneous Coronary Intervention. Journal Of The Society For Cardiovascular Angiography & Interventions 2024, 3: 101981. PMID: 39166169, PMCID: PMC11330901, DOI: 10.1016/j.jscai.2024.101981.Peer-Reviewed Original ResearchSYNTAX I scoreHigh-risk percutaneous coronary interventionPercutaneous coronary interventionCoronary interventionSYNTAX IIII studiesSYNTAX scoreI scoresAssociated with higher ratesComplex coronary artery diseaseCoronary artery diseaseMultivariate regression analysisMechanical circulatory supportInterventionClinical outcomesPoor outcomeCerebrovascular eventsRegression analysisArtery diseasePost-PCIPatientsCirculatory supportProcedural factorsHigher ratesOutcomesTreatment of Acute Myocardial Infarction and Cardiogenic Shock: Outcomes of the RECOVER III Postapproval Study by Society of Cardiovascular Angiography and Interventions Shock Stage
Hanson I, Rusia A, Palomo A, Tawney A, Pow T, Dixon S, Meraj P, Sievers E, Johnson M, Wohns D, Ali O, Kapur N, Grines C, Burkhoff D, Anderson M, Lansky A, Naidu S, Basir M, O'Neill W. Treatment of Acute Myocardial Infarction and Cardiogenic Shock: Outcomes of the RECOVER III Postapproval Study by Society of Cardiovascular Angiography and Interventions Shock Stage. Journal Of The American Heart Association 2024, 13: e031803. PMID: 38293995, PMCID: PMC11056148, DOI: 10.1161/jaha.123.031803.Peer-Reviewed Original ResearchConceptsSociety for Cardiovascular AngiographyCardiovascular AngiographyAcute myocardial infarctionIII studiesCardiogenic shockStage CPercutaneous coronary interventionMyocardial infarctionPostapproval studiesCoronary interventionImpella supportKaplan-Meier survival curve analysisSociety of Cardiovascular AngiographyThirty-day survivalResponse to therapyCohort of patientsStudy of patientsPredictors of mortalitySurvival curve analysisTreatment of acute myocardial infarctionPredictive of mortalitySeverity of shockSingle-armThirty-dayStaging system
2023
Influence of left ventricular ejection fraction in patients undergoing contemporary pLVAD-supported high-risk PCI
Abu-Much A, Grines C, Batchelor W, Maini A, Zhang Y, Redfors B, Bellumkonda L, Bharadwaj A, Moses J, Truesdell A, Li Y, Baron S, Lansky A, Basir M, Cohen D, O'Neill W. Influence of left ventricular ejection fraction in patients undergoing contemporary pLVAD-supported high-risk PCI. American Heart Journal 2023, 269: 139-148. PMID: 38151142, DOI: 10.1016/j.ahj.2023.12.015.Peer-Reviewed Original ResearchBaseline LV ejection fractionLV ejection fractionPercutaneous coronary interventionPCI-related complicationsLV dysfunctionEjection fractionLV functionLeft main percutaneous coronary interventionHigh-risk percutaneous coronary interventionHigh-risk PCI patientsImmediate percutaneous coronary interventionMain percutaneous coronary interventionModerate LV dysfunctionSevere LV dysfunctionVentricular systolic dysfunctionVentricular ejection fractionCoronary complicationsLVEF groupMACCE rateCerebrovascular eventsPCI patientsSystolic dysfunctionCoronary interventionIII studyMyocardial infarctionTargeted therapy with a localised abluminal groove, low-dose sirolimus-eluting, biodegradable-polymer coronary stent - five-year results of the TARGET All Comers randomised clinical trial.
Lansky A, Xu B, Baumbach A, Kelbæk H, van Royen N, Zheng M, Knaapen P, Slagboom T, Johnson T, Vlachojannis G, Arkenbout K, Holmvang L, Janssens L, Brugaletta S, Naber C, Schmitz T, Anderson R, Rittger H, Berti S, Barbato E, Toth G, Maillard L, Valina C, Buszman P, Thiele H, Schächinger V, Wijns W. Targeted therapy with a localised abluminal groove, low-dose sirolimus-eluting, biodegradable-polymer coronary stent - five-year results of the TARGET All Comers randomised clinical trial. EuroIntervention 2023, 19: e844-e855. PMID: 37860860, PMCID: PMC10687649, DOI: 10.4244/eij-d-23-00409.Peer-Reviewed Original ResearchConceptsTarget lesion failureDP-EES groupPercutaneous coronary interventionBP-SES groupBP-SESPrimary endpointDP-EESRate of TLFBiodegradable polymer sirolimus-eluting stentsST-elevation myocardial infarction (STEMI) presentationMyocardial infarction presentationSirolimus-eluting stentsFive-year resultsLong-term safetyAbluminal grooveLesion failureSecondary endpointsComers populationCoronary interventionMyocardial ischaemiaStent implantationClinical trialsTargeted therapyLandmark analysisStudy outcomesCharacteristics and outcomes of elderly patients undergoing protected percutaneous coronary intervention with impella mechanical circulatory support
Jakob P, Falah B, Abu-Much A, Lansky A, Basir M, Schonning M, Zhou Z, Batchelor W, Grines C, O'neill W, Stahli B. Characteristics and outcomes of elderly patients undergoing protected percutaneous coronary intervention with impella mechanical circulatory support. European Heart Journal 2023, 44: ehad655.2209. DOI: 10.1093/eurheartj/ehad655.2209.Peer-Reviewed Original ResearchHigh-risk percutaneous coronary interventionPercutaneous coronary interventionMechanical circulatory supportYears of ageCirculatory supportMyocardial infarctionCoronary interventionElderly patientsClinical outcomesStroke/transient ischemic attackMain percutaneous coronary interventionMultivariable Cox regression modelsSevere valvular heart diseaseLeft ventricular ejection fractionLower body mass indexBaseline SYNTAX scoreTransient ischemic attackHigh-risk patientsGlomerular filtration ratePrior myocardial infarctionVentricular ejection fractionValvular heart diseaseBody mass indexCox regression modelRisk of mortalityCurrent Landscape and Future Directions of Coronary Revascularization in Ischemic Systolic Heart Failure: A Review
Chuy K, Velazquez E, Lansky A, Jamil Y, Ahmad Y. Current Landscape and Future Directions of Coronary Revascularization in Ischemic Systolic Heart Failure: A Review. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 101197. PMID: 39131064, PMCID: PMC11307589, DOI: 10.1016/j.jscai.2023.101197.Peer-Reviewed Original ResearchIschemic systolic heart failureSystolic heart failurePercutaneous coronary interventionHeart failureMedical therapyCoronary revascularizationBenefits of PCITrials of PCILeft ventricular systolic dysfunctionPrevalence of HFBenefit of CABGContemporary medical therapyIschemic ventricular dysfunctionCoronary artery bypassVentricular systolic dysfunctionCoronary artery diseaseIschemic heart diseaseAcute cardiac careComparative clinical effectivenessUnmet clinical needRecent revascularizationArtery bypassSystolic dysfunctionVentricular dysfunctionCoronary interventionImpact and Implications of Neurocognitive Dysfunction in the Management of Ischemic Heart Failure
Tirziu D, Kołodziejczak M, Grubman D, Carrión C, Driskell L, Ahmad Y, Petrie M, Omerovic E, Redfors B, Fremes S, Browndyke J, Lansky A. Impact and Implications of Neurocognitive Dysfunction in the Management of Ischemic Heart Failure. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 101198. PMID: 39131066, PMCID: PMC11308118, DOI: 10.1016/j.jscai.2023.101198.Peer-Reviewed Original ResearchIschemic heart failureHeart failureNeurocognitive dysfunctionCognitive impairmentCoronary Artery Bypass GraftingArtery Bypass GraftingChronic cerebral hypoperfusionCoronary artery bypassPercutaneous coronary interventionPoor cognitive functionArtery bypassBypass GraftingCardiovascular outcomesCerebral hypoperfusionCoronary revascularizationCerebral hypoxiaCoronary interventionNeurologic injuryCardiac outputWorse outcomesBrain damageBrain injuryPatient outcomesInvasive approachPatient managementTCT-641 Intravascular Imaging-Guided Versus Angiography-Guided Percutaneous Coronary Intervention: A Meta-Analysis of Randomized Trials
Sreenivasan J, Reddy R, Jamil Y, Malik A, Chamie D, Howard J, Nanna M, Mintz G, Maehara A, Ali Z, Moses J, Chen S, Chieffo A, Colombo A, Leon M, Lansky A, Ahmad Y. TCT-641 Intravascular Imaging-Guided Versus Angiography-Guided Percutaneous Coronary Intervention: A Meta-Analysis of Randomized Trials. Journal Of The American College Of Cardiology 2023, 82: b258. DOI: 10.1016/j.jacc.2023.09.652.Peer-Reviewed Original ResearchTCT-219 Performance of Existing Risk Models in Impella-Supported High-Risk Percutaneous Coronary Intervention
Shah T, Lemor A, Thompson J, Protty M, Mamas M, Kinnaird T, Bharadwaj A, Truesdell A, Zhang Y, Hussain Y, Falah B, Cohen D, Redfors B, Baron S, Witzke C, Dixon S, Lansky A, Basir B, O’Neill W. TCT-219 Performance of Existing Risk Models in Impella-Supported High-Risk Percutaneous Coronary Intervention. Journal Of The American College Of Cardiology 2023, 82: b85. DOI: 10.1016/j.jacc.2023.09.226.Peer-Reviewed Original ResearchTCT-240 A-SMART-EF: A Novel Score to Predict Mortality in Patients Undergoing Impella-Assisted Percutaneous Coronary Intervention
Lemor A, Shah T, Thompson J, Protty M, Mamas M, Kinnaird T, Bharadwaj A, Truesdell A, Zhang Y, Cohen D, Falah B, Redfors B, Baron S, Witzke C, Dixon S, Lansky A, Basir B, O’Neill W. TCT-240 A-SMART-EF: A Novel Score to Predict Mortality in Patients Undergoing Impella-Assisted Percutaneous Coronary Intervention. Journal Of The American College Of Cardiology 2023, 82: b93-b94. DOI: 10.1016/j.jacc.2023.09.247.Peer-Reviewed Original ResearchTCT-214 Right Ventricular Function in Patients Undergoing Impella-Assisted High-Risk Percutaneous Coronary Intervention: Insights From the cVAD PROTECT III Study
Rommel K, Bonnet G, Bellumkonda L, Zhang Y, Lansky A, Redfors B, Granada J, Bharadwaj A, Basir B, Patel R, O’Neill W, Burkhoff D. TCT-214 Right Ventricular Function in Patients Undergoing Impella-Assisted High-Risk Percutaneous Coronary Intervention: Insights From the cVAD PROTECT III Study. Journal Of The American College Of Cardiology 2023, 82: b82-b83. DOI: 10.1016/j.jacc.2023.09.221.Peer-Reviewed Original ResearchTCT-216 Defining High-Risk Percutaneous Coronary Intervention: Characteristics of Patients Undergoing Contemporary Percutaneous Coronary Intervention With Axial-Flow Mechanical Support
Bharadwaj A, Truesdell A, Lemor A, Thompson J, Abu-Much A, Zhang Y, Schonning M, Redfors B, Cohen D, Witzke C, Matthews R, Dixon S, Lansky A, O’Neill W. TCT-216 Defining High-Risk Percutaneous Coronary Intervention: Characteristics of Patients Undergoing Contemporary Percutaneous Coronary Intervention With Axial-Flow Mechanical Support. Journal Of The American College Of Cardiology 2023, 82: b83-b84. DOI: 10.1016/j.jacc.2023.09.223.Peer-Reviewed Original ResearchImpella Utilization in High-Risk Percutaneous Coronary Intervention Mitigates the Risks of Procedural and Clinical Adverse Events Independent of Left Ventricular Ejection Fraction: The Protect III Study
Abu-Much A, Maini A, Grines C, Bharadwaj A, Moses J, Zhang Y, Redfors B, Bellumkonda L, Li Y, Truesdell A, Baron S, Lansky A, Basir M, O'Neill W. Impella Utilization in High-Risk Percutaneous Coronary Intervention Mitigates the Risks of Procedural and Clinical Adverse Events Independent of Left Ventricular Ejection Fraction: The Protect III Study. Cardiovascular Revascularization Medicine 2023, 53: s126. DOI: 10.1016/j.carrev.2023.05.290.Peer-Reviewed Original ResearchShort-Term Outcomes Among Aortic Valve Stenosis Patients Undergoing Impella-Supported High-Risk Percutaneous Coronary Intervention
Velagapudi P, Abu-Much A, Bellumkonda L, Maini A, Redfors B, Lansky A, Li Y, Grines C, Batchelor W, O'Neill W, Cohen D. Short-Term Outcomes Among Aortic Valve Stenosis Patients Undergoing Impella-Supported High-Risk Percutaneous Coronary Intervention. Cardiovascular Revascularization Medicine 2023, 53: s110. DOI: 10.1016/j.carrev.2023.05.253.Peer-Reviewed Original ResearchEffect of Race on Clinical Outcomes Following Hemodynamically Supported High-Risk Percutaneous Coronary Intervention
Fuller B, Basir M, Grines C, Voeltz M, Batchelor W, Lansky A, O’Neill W. Effect of Race on Clinical Outcomes Following Hemodynamically Supported High-Risk Percutaneous Coronary Intervention. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 100588. PMID: 39129816, PMCID: PMC11307497, DOI: 10.1016/j.jscai.2023.100588.Peer-Reviewed Original ResearchAntiplatelet Strategies Following PCI: A Review of Trials Informing Current and Future Therapies
Thomas A, Gitto M, Shah S, Saito Y, Tirziu D, Chieffo A, Stefanini G, Lansky A. Antiplatelet Strategies Following PCI: A Review of Trials Informing Current and Future Therapies. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 100607. PMID: 39130709, PMCID: PMC11307978, DOI: 10.1016/j.jscai.2023.100607.Peer-Reviewed Original ResearchDual antiplatelet therapyAntiplatelet regimensPatient-specific risk profileShorter DAPT durationDuration of therapyPercutaneous coronary interventionDAPT strategyIschemic riskAntiplatelet therapyDAPT durationAntiplatelet strategiesCoronary interventionOngoing trialsMajor trialsRecent trialsPractice guidelinesFuture therapiesRisk profileTherapyStent technologyTrialsRegimensNumber of trialsSignificant reductionSignificant changesCRT-700.34 Short-Term Outcomes Among Aortic Valve Stenosis Patients Undergoing Impella-Supported High-Risk Percutaneous Coronary Intervention
Velagapudi P, Abu-Much A, Bellumkonda L, Maini A, Redfors B, Lansky A, Li Y, Grines C, Batchelor W, O'Neill W, Cohen D. CRT-700.34 Short-Term Outcomes Among Aortic Valve Stenosis Patients Undergoing Impella-Supported High-Risk Percutaneous Coronary Intervention. JACC Cardiovascular Interventions 2023, 16: s92-s93. DOI: 10.1016/j.jcin.2023.01.291.Peer-Reviewed Original ResearchCRT-700.05 Impella Utilization in High-Risk Percutaneous Coronary Intervention Mitigates the Risks of Procedural and Clinical Adverse Events Independent of Left Ventricular Ejection Fraction: The Protect III Study
Abu-Much A, Maini A, Grines C, Bharadwaj A, Moses J, Zhang Y, Redfors B, Bellumkonda L, Li Y, Truesdell A, Baron S, Lansky A, Basir M, O'Neill W. CRT-700.05 Impella Utilization in High-Risk Percutaneous Coronary Intervention Mitigates the Risks of Procedural and Clinical Adverse Events Independent of Left Ventricular Ejection Fraction: The Protect III Study. JACC Cardiovascular Interventions 2023, 16: s107. DOI: 10.1016/j.jcin.2023.01.337.Peer-Reviewed Original Research