2015
Effect of Ischemia Duration and Door-to-Balloon Time on Myocardial Perfusion in ST-Segment Elevation Myocardial Infarction An Analysis From HORIZONS-AMI Trial (Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction)
Prasad A, Gersh BJ, Mehran R, Brodie BR, Brener SJ, Dizon JM, Lansky AJ, Witzenbichler B, Kornowski R, Guagliumi G, Dudek D, Stone GW. Effect of Ischemia Duration and Door-to-Balloon Time on Myocardial Perfusion in ST-Segment Elevation Myocardial Infarction An Analysis From HORIZONS-AMI Trial (Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction). JACC Cardiovascular Interventions 2015, 8: 1966-1974. PMID: 26738667, DOI: 10.1016/j.jcin.2015.08.031.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCoronary CirculationDrug-Eluting StentsFemaleHumansMaleMetalsMicrocirculationMiddle AgedMyocardial InfarctionMyocardial Perfusion ImagingPercutaneous Coronary InterventionProspective StudiesProsthesis DesignRisk AssessmentRisk FactorsStentsTime FactorsTime-to-TreatmentTreatment OutcomeConceptsPrimary percutaneous coronary interventionMyocardial blush gradePrimary PCIHORIZONS-AMI trialMBG 0/1Balloon timeIndependent predictorsAnterior infarctionMyocardial perfusionST-segment elevation myocardial infarction (STEMI) patientsST-segment elevation myocardial infarctionHigher clinical risk profileElevation myocardial infarction patientsMyocardial Infarction (TIMI) risk scoreClinical risk profileMechanical reperfusion therapyReference vessel diameterElevation myocardial infarctionPercutaneous coronary interventionST-segment elevationEpicardial blood flowMinimum lumen diameterMyocardial infarction patientsMicrovascular reperfusionBlush grade
2007
Impact of Time to Treatment on Myocardial Reperfusion and Infarct Size With Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction (from the EMERALD Trial)
Brodie BR, Webb J, Cox DA, Qureshi M, Kalynych A, Turco M, Schultheiss HP, Dulas D, Rutherford B, Antoniucci D, Stuckey T, Krucoff M, Gibbons R, Lansky A, Na Y, Mehran R, Stone GW, Investigators E. Impact of Time to Treatment on Myocardial Reperfusion and Infarct Size With Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction (from the EMERALD Trial). The American Journal Of Cardiology 2007, 99: 1680-1686. PMID: 17560875, DOI: 10.1016/j.amjcard.2007.01.047.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionPrimary PCIPercutaneous coronary interventionSmaller infarct sizeInfarct sizeNonanterior infarctionDistal protectionCoronary interventionMyocardial infarctionST-elevation myocardial infarctionHigh-risk patientsTriage of patientsAcute myocardial infarctionEMERALD trialImpact of timeControl patientsEarly reperfusionMyocardial reperfusionClinical outcomesAnterior infarctionMyocardial blushReperfusionInfarctionMortality ratePatients
2006
Relationship between infarct artery location, epicardial flow, and myocardial perfusion after primary percutaneous revascularization in acute myocardial infarction
Kandzari DE, Tcheng JE, Gersh BJ, Cox DA, Stuckey T, Turco M, Mehran R, Garcia E, Zimetbaum P, McGlaughlin MG, Lansky AJ, Costantini CO, Grines CL, Stone GW, Investigators F. Relationship between infarct artery location, epicardial flow, and myocardial perfusion after primary percutaneous revascularization in acute myocardial infarction. American Heart Journal 2006, 151: 1288-1295. PMID: 16781238, DOI: 10.1016/j.ahj.2005.08.017.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionAcute myocardial infarctionPrimary PCIST-segment resolutionMyocardial infarctionReperfusion successVentricular functionClinical outcomesCollateral flowAnterior infarctionMyocardial perfusionArtery locationFinal TIMI 3 flowIschemic target vessel revascularizationMajor adverse cardiac eventsReduced left ventricular functionRight coronary artery distributionPrimary percutaneous revascularizationAdverse cardiac eventsBaseline clinical characteristicsTarget vessel revascularizationTIMI 3 flowMyocardial blush gradePowerful independent predictorPercutaneous coronary intervention