2020
The utility and limitations of B- and T-cell gene rearrangement studies in evaluating lymphoproliferative disorders
Mendoza H, Tormey CA, Rinder HM, Howe JG, Siddon AJ. The utility and limitations of B- and T-cell gene rearrangement studies in evaluating lymphoproliferative disorders. Pathology 2020, 53: 157-165. PMID: 33358756, DOI: 10.1016/j.pathol.2020.09.024.Peer-Reviewed Original ResearchConceptsTCR gene rearrangement analysisGene rearrangement analysisPolymerase chain reactionRearrangement analysisLymphocyte populationsLymphoid malignanciesT-cell receptor gene rearrangement analysisT-cell gene rearrangement studiesTCR gene rearrangement patternsT cell populationsGene rearrangement studiesNext-generation sequencingGene rearrangement patternsLymphoproliferative disorders
2018
False-Positive Light Chain Clonal Restriction by Flow Cytometry in Patients Treated With Alemtuzumab
Chen PP, Tormey CA, Eisenbarth SC, Torres R, Richardson SS, Rinder HM, Smith BR, Siddon AJ. False-Positive Light Chain Clonal Restriction by Flow Cytometry in Patients Treated With Alemtuzumab. American Journal Of Clinical Pathology 2018, 151: 154-163. PMID: 30307483, DOI: 10.1093/ajcp/aqy129.Peer-Reviewed Original ResearchConceptsHealthy donor bloodAlemtuzumab treatmentDonor bloodBone marrowFlow cytometryLight chain restrictionT-cell prolymphocytic leukemiaB-cell neoplasmsLight chain clonalityFlow cytometry analysisAutoimmune diseasesHematologic malignanciesImmunophenotypic analysisChain restrictionAlemtuzumabT cellsB cellsProlymphocytic leukemiaImmunoglobulin G1PatientsMonoclonal antibodiesCytometry analysisSimilar findingsBloodClonal restriction