2021
Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo
Shao LX, Liao C, Gregg I, Davoudian PA, Savalia NK, Delagarza K, Kwan AC. Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo. Neuron 2021, 109: 2535-2544.e4. PMID: 34228959, PMCID: PMC8376772, DOI: 10.1016/j.neuron.2021.06.008.Peer-Reviewed Original ResearchConceptsFrontal cortexDendritic spinesMouse medial frontal cortexLayer 5 pyramidal neuronsSpine formation ratesApical dendritic spinesMedial frontal cortexUntapped therapeutic potentialPyramidal neuronsSingle doseExcitatory neurotransmissionBehavioral deficitsBeneficial actionsStructural remodelingSynaptic rewiringMammalian brainTherapeutic potentialNeural adaptationUse of psychedelicsSerotonergic psychedelicsSpine sizeTwo-photon microscopyCortexPsilocybinSpine
2020
Ketamine disinhibits dendrites and enhances calcium signals in prefrontal dendritic spines
Ali F, Gerhard DM, Sweasy K, Pothula S, Pittenger C, Duman RS, Kwan AC. Ketamine disinhibits dendrites and enhances calcium signals in prefrontal dendritic spines. Nature Communications 2020, 11: 72. PMID: 31911591, PMCID: PMC6946708, DOI: 10.1038/s41467-019-13809-8.Peer-Reviewed Original ResearchConceptsDendritic spinesN-methyl-D-aspartate receptor antagonistPrefrontal cortexPrefrontal dendritic spinesApical dendritic spinesSomatostatin-expressing (SST) interneuronsCortico-cortical connectivityElevated calcium levelsMedial prefrontal cortexKetamine actsAntidepressant effectsGABAergic neuronsSST interneuronsKetamine actionPyramidal neuronsNMDAR antagonismReceptor antagonistSubanesthetic ketamineSubanesthetic doseDendritic inhibitionAwake miceCortical interneuronsSynaptic inputsCalcium levelsCalcium transients