2024
Ventral hippocampal parvalbumin interneurons gate the acute anxiolytic action of the serotonergic psychedelic DOI
Tiwari P, Davoudian P, Kapri D, Vuruputuri R, Karaba L, Sharma M, Zanni G, Balakrishnan A, Chaudhari P, Pradhan A, Suryavanshi S, Bath K, Ansorge M, Fernandez-Ruiz A, Kwan A, Vaidya V. Ventral hippocampal parvalbumin interneurons gate the acute anxiolytic action of the serotonergic psychedelic DOI. Neuron 2024 PMID: 39321791, DOI: 10.1016/j.neuron.2024.08.016.Peer-Reviewed Original ResearchAnxiolytic actionVentral hippocampusParvalbumin (PV)-positive interneuronsAnxiety-like behaviorAction of DOIPV-positive interneuronsPsychedelic DOIAnxiolytic responseAnxiolytic effectsSerotonergic psychedelicsFast-spiking cellsParvalbumin interneuronsGABAergic interneuronsVHPCFiring rateDOIHippocampusInterneuronsTherapeutic potentialReceptorsPsychedelicsCellular triggersGenetic approachesElectrophysiology
2023
Timing is key for behavioural benefits of psychedelics
Woodburn S, Kwan A. Timing is key for behavioural benefits of psychedelics. Nature 2023, 618: 677-678. PMID: 37316593, DOI: 10.1038/d41586-023-01869-2.Peer-Reviewed Original ResearchMeSH KeywordsHallucinogens
2022
Psychedelics and Neural Plasticity: Therapeutic Implications
Grieco S, Castrén E, Knudsen G, Kwan A, Olson D, Zuo Y, Holmes T, Xu X. Psychedelics and Neural Plasticity: Therapeutic Implications. Journal Of Neuroscience 2022, 42: 8439-8449. PMID: 36351821, PMCID: PMC9665925, DOI: 10.1523/jneurosci.1121-22.2022.Peer-Reviewed Original ResearchConceptsTherapeutic effectNeural plasticityUnmet clinical needFunctional neural plasticityBrain-wide circuitsPsychedelic drugsClinical trialsBasic neuroscience questionsReceptor binding sitesTherapeutic implicationsBrain disordersClinical researchPsychedelic effectsBrain functionClinical needEffects of psychedelicsDrugsNeural mechanismsFuture studiesPsychedelicsGene expressionNeuroscience questionsClinicTrialsThe neural basis of psychedelic action
Kwan A, Olson D, Preller K, Roth B. The neural basis of psychedelic action. Nature Neuroscience 2022, 25: 1407-1419. PMID: 36280799, PMCID: PMC9641582, DOI: 10.1038/s41593-022-01177-4.Peer-Reviewed Original ResearchConceptsSerotonin 2A receptor agonistThalamocortical functional connectivityDownstream molecular signaling pathwaysDrug discoveryMolecular signaling pathwaysReceptor agonistSerotonin receptorsAssociation cortexPsychedelic actionSustained effectSubcortical regionsBasic neurobiologyFunctional connectivityTranscriptional changesPsychoactive moleculesSignaling pathwaysNeural mechanismsStructural plasticityNeural basisPsychedelic drugsChemistryPsychedelicsEnduring effectMoleculesAgonists
2020
A Dendrite-Focused Framework for Understanding the Actions of Ketamine and Psychedelics
Savalia NK, Shao LX, Kwan AC. A Dendrite-Focused Framework for Understanding the Actions of Ketamine and Psychedelics. Trends In Neurosciences 2020, 44: 260-275. PMID: 33358035, PMCID: PMC7990695, DOI: 10.1016/j.tins.2020.11.008.Books