Psychedelics and Neural Plasticity: Therapeutic Implications
Grieco S, Castrén E, Knudsen G, Kwan A, Olson D, Zuo Y, Holmes T, Xu X. Psychedelics and Neural Plasticity: Therapeutic Implications. Journal Of Neuroscience 2022, 42: 8439-8449. PMID: 36351821, PMCID: PMC9665925, DOI: 10.1523/jneurosci.1121-22.2022.Peer-Reviewed Original ResearchConceptsTherapeutic effectNeural plasticityUnmet clinical needFunctional neural plasticityBrain-wide circuitsPsychedelic drugsClinical trialsBasic neuroscience questionsReceptor binding sitesTherapeutic implicationsBrain disordersClinical researchPsychedelic effectsBrain functionClinical needEffects of psychedelicsDrugsNeural mechanismsFuture studiesPsychedelicsGene expressionNeuroscience questionsClinicTrialsThe neural basis of psychedelic action
Kwan A, Olson D, Preller K, Roth B. The neural basis of psychedelic action. Nature Neuroscience 2022, 25: 1407-1419. PMID: 36280799, PMCID: PMC9641582, DOI: 10.1038/s41593-022-01177-4.Peer-Reviewed Original ResearchConceptsSerotonin 2A receptor agonistThalamocortical functional connectivityDownstream molecular signaling pathwaysDrug discoveryMolecular signaling pathwaysReceptor agonistSerotonin receptorsAssociation cortexPsychedelic actionSustained effectSubcortical regionsBasic neurobiologyFunctional connectivityTranscriptional changesPsychoactive moleculesSignaling pathwaysNeural mechanismsStructural plasticityNeural basisPsychedelic drugsChemistryPsychedelicsEnduring effectMoleculesAgonists