2024
Psilocybin Facilitates Fear Extinction: Importance of Dose, Context, and Serotonin Receptors
Woodburn S, Levitt C, Koester A, Kwan A. Psilocybin Facilitates Fear Extinction: Importance of Dose, Context, and Serotonin Receptors. ACS Chemical Neuroscience 2024, 15: 3034-3043. PMID: 39087917, DOI: 10.1021/acschemneuro.4c00279.Peer-Reviewed Original ResearchPost-traumatic stress disorderFear extinctionFear renewalExtinction retentionSerotonin receptorsPsilocybin effectsEffects of psilocybinExtinction-based therapiesProlonged exposure therapyFear conditioning paradigmAnalysis of sex differencesEnhanced fear extinctionFear learning paradigmAdministration of psilocybinConditioning paradigmExposure therapyFear learningStress disorderClassic psychedelicsPsilocybinSex differencesExtinction experimentsReceptor antagonismDrug effectsSerotonin
2021
Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo
Shao LX, Liao C, Gregg I, Davoudian PA, Savalia NK, Delagarza K, Kwan AC. Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo. Neuron 2021, 109: 2535-2544.e4. PMID: 34228959, PMCID: PMC8376772, DOI: 10.1016/j.neuron.2021.06.008.Peer-Reviewed Original ResearchConceptsFrontal cortexDendritic spinesMouse medial frontal cortexLayer 5 pyramidal neuronsSpine formation ratesApical dendritic spinesMedial frontal cortexUntapped therapeutic potentialPyramidal neuronsSingle doseExcitatory neurotransmissionBehavioral deficitsBeneficial actionsStructural remodelingSynaptic rewiringMammalian brainTherapeutic potentialNeural adaptationUse of psychedelicsSerotonergic psychedelicsSpine sizeTwo-photon microscopyCortexPsilocybinSpine