Differential responses of epithelial cells from urinary and biliary tract to eggs of Schistosoma haematobium and S. mansoni
Nacif-Pimenta R, da Silva Orfanó A, Mosley IA, Karinshak SE, Ishida K, Mann VH, Coelho PMZ, da Costa JMC, Hsieh MH, Brindley PJ, Rinaldi G. Differential responses of epithelial cells from urinary and biliary tract to eggs of Schistosoma haematobium and S. mansoni. Scientific Reports 2019, 9: 10731. PMID: 31341177, PMCID: PMC6656753, DOI: 10.1038/s41598-019-46917-y.Peer-Reviewed Original ResearchConceptsSchistosome eggsEpithelial cellsS. haematobiumS. mansoniUrothelial cellsS. mansoni eggsS. haematobium eggsSquamous cell carcinomaCell proliferative responsesGroup 1 carcinogenHepatointestinal schistosomiasisPeriportal fibrosisBiliary tractMansoni eggsCell carcinomaChronic infectionUrogenital schistosomiasisEstrogen receptorProliferative responseDefinitive causeSchistosoma haematobiumNormal urotheliumHuman epithelial cellsMesenchymal transitionS. japonicum