2016
FAT1 mutations cause a glomerulotubular nephropathy
Gee HY, Sadowski CE, Aggarwal PK, Porath JD, Yakulov TA, Schueler M, Lovric S, Ashraf S, Braun DA, Halbritter J, Fang H, Airik R, Vega-Warner V, Cho KJ, Chan TA, Morris LG, ffrench-Constant C, Allen N, McNeill H, Büscher R, Kyrieleis H, Wallot M, Gaspert A, Kistler T, Milford DV, Saleem MA, Keng WT, Alexander SI, Valentini RP, Licht C, Teh JC, Bogdanovic R, Koziell A, Bierzynska A, Soliman NA, Otto EA, Lifton RP, Holzman LB, Sibinga NE, Walz G, Tufro A, Hildebrandt F. FAT1 mutations cause a glomerulotubular nephropathy. Nature Communications 2016, 7: 10822. PMID: 26905694, PMCID: PMC4770090, DOI: 10.1038/ncomms10822.Peer-Reviewed Original ResearchConceptsSteroid-resistant nephrotic syndromeChronic kidney diseaseKnockdown of Fat1Podocyte foot process effacementTubular cell functionRenal tubular cellsFoot process effacementNephrotic syndromeNeurological involvementKidney diseaseFAT1 mutationsDisease entityPodocyte-specific deletionTubular cellsTubular ectasiaProcess effacementCell functionDecreased migrationRac1/Cdc42PathogenesisFAT1Barrier developmentKnockdownRecessive mutationsHaematuria
2006
Semaphorin 3C regulates endothelial cell function by increasing integrin activity
Banu N, Teichman J, Dunlap‐Brown M, Villegas G, Tufro A, Banu N, Teichman J, Dunlap‐Brown M, Villegas G, Tufro A. Semaphorin 3C regulates endothelial cell function by increasing integrin activity. The FASEB Journal 2006, 20: 2150-2152. PMID: 16940438, DOI: 10.1096/fj.05-5698fje.Peer-Reviewed Original ResearchConceptsSema 3CEndothelial cell functionDirectional migrationStarvation-induced apoptosisCell functionCapillary-like network formationCardiovascular patterningClass 3 semaphorinsIntegrin phosphorylationSerine phosphorylationCollagen I gelsVascular morphogenesisEndothelial cellsMouse glomerular endothelial cellsIntegrin activityGuidance proteinsEndothelial cell proliferationIntegrin inhibitionCaspase-3Cell proliferationSitu markerTube formationSemaphorin 3CPhosphorylationGrowth factor