Semaphorin 3C regulates endothelial cell function by increasing integrin activity
Banu N, Teichman J, Dunlap‐Brown M, Villegas G, Tufro A, Banu N, Teichman J, Dunlap‐Brown M, Villegas G, Tufro A. Semaphorin 3C regulates endothelial cell function by increasing integrin activity. The FASEB Journal 2006, 20: 2150-2152. PMID: 16940438, DOI: 10.1096/fj.05-5698fje.Peer-Reviewed Original ResearchConceptsSema 3CEndothelial cell functionDirectional migrationStarvation-induced apoptosisCell functionCapillary-like network formationCardiovascular patterningClass 3 semaphorinsIntegrin phosphorylationSerine phosphorylationCollagen I gelsVascular morphogenesisEndothelial cellsMouse glomerular endothelial cellsIntegrin activityGuidance proteinsEndothelial cell proliferationIntegrin inhibitionCaspase-3Cell proliferationSitu markerTube formationSemaphorin 3CPhosphorylationGrowth factorAutocrine class 3 semaphorin system regulates slit diaphragm proteins and podocyte survival
Guan F, Villegas G, Teichman J, Mundel P, Tufro A. Autocrine class 3 semaphorin system regulates slit diaphragm proteins and podocyte survival. Kidney International 2006, 69: 1564-1569. PMID: 16541019, DOI: 10.1038/sj.ki.5000313.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsApoptosisAutocrine CommunicationCells, CulturedCytoskeletal ProteinsDown-RegulationIntracellular Signaling Peptides and ProteinsKidney GlomerulusMembrane ProteinsMicePhosphorylationPodocytesProteinsProto-Oncogene Proteins c-aktReceptors, Cell SurfaceReceptors, ImmunologicSemaphorin-3ASemaphorinsConceptsReverse transcriptase-polymerase chain reactionClass 3 semaphorinsPodocyte survivalSlit diaphragm proteinsSema 3APodocyte apoptosisDiaphragm proteinsTranscriptase-polymerase chain reactionDifferentiated podocytesSema 3A.Activity markersAkt survival pathwayDifferentiated mouse podocytesSemaphorin 3ASemaphorin 3BGuidance proteinsMouse podocytesPodocytesMRNA levelsSurvival pathwaysUndetectable levelsChain reactionPlexin-A1SurvivalSemaphorin Regulation