Autocrine class 3 semaphorin system regulates slit diaphragm proteins and podocyte survival
Guan F, Villegas G, Teichman J, Mundel P, Tufro A. Autocrine class 3 semaphorin system regulates slit diaphragm proteins and podocyte survival. Kidney International 2006, 69: 1564-1569. PMID: 16541019, DOI: 10.1038/sj.ki.5000313.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsApoptosisAutocrine CommunicationCells, CulturedCytoskeletal ProteinsDown-RegulationIntracellular Signaling Peptides and ProteinsKidney GlomerulusMembrane ProteinsMicePhosphorylationPodocytesProteinsProto-Oncogene Proteins c-aktReceptors, Cell SurfaceReceptors, ImmunologicSemaphorin-3ASemaphorinsConceptsReverse transcriptase-polymerase chain reactionClass 3 semaphorinsPodocyte survivalSlit diaphragm proteinsSema 3APodocyte apoptosisDiaphragm proteinsTranscriptase-polymerase chain reactionDifferentiated podocytesSema 3A.Activity markersAkt survival pathwayDifferentiated mouse podocytesSemaphorin 3ASemaphorin 3BGuidance proteinsMouse podocytesPodocytesMRNA levelsSurvival pathwaysUndetectable levelsChain reactionPlexin-A1SurvivalSemaphorin Regulation