2019
Effects of Aging on Human Toll-Like Receptor Function
Shaw A. Effects of Aging on Human Toll-Like Receptor Function. 2019, 981-992. DOI: 10.1007/978-3-319-99375-1_98.Peer-Reviewed Original ResearchInnate immune pattern recognition receptorsPattern recognition receptorsImmune pattern recognition receptorsToll-like receptorsTLR functionAdaptive immunityImmune systemEndogenous ligandAge-related chronic inflammationToll-like receptor functionT cell responsesInnate immune primingInnate immune systemAge-associated alterationsCombination of alterationsAge-related changesEffect of ageDendritic cellsInflammatory dysregulationChronic inflammationImmune primingRecognition receptorsCell responsesReceptor functionOlder adults
2018
Effects of Aging on Human Toll-Like Receptor Function
Shaw A. Effects of Aging on Human Toll-Like Receptor Function. 2018, 1-12. DOI: 10.1007/978-3-319-64597-1_98-1.Peer-Reviewed Original ResearchInnate immune pattern recognition receptorsPattern recognition receptorsImmune pattern recognition receptorsToll-like receptorsTLR functionAdaptive immunityImmune systemEndogenous ligandAge-related chronic inflammationToll-like receptor functionT cell responsesInnate immune primingInnate immune systemAge-associated alterationsCombination of alterationsAge-related changesEffect of ageDendritic cellsInflammatory dysregulationChronic inflammationImmune primingRecognition receptorsReceptor functionOlder adultsYoung adultsImpact of Aging and HIV Infection on the Function of the C-Type Lectin Receptor MINCLE in Monocytes
Zapata HJ, Van Ness PH, Avey S, Siconolfi B, Allore HG, Tsang S, Wilson J, Barakat L, Mohanty S, Shaw AC. Impact of Aging and HIV Infection on the Function of the C-Type Lectin Receptor MINCLE in Monocytes. The Journals Of Gerontology Series A 2018, 74: 794-801. PMID: 30239628, PMCID: PMC6521921, DOI: 10.1093/gerona/gly209.Peer-Reviewed Original ResearchConceptsPro-inflammatory environmentHIV infectionInnate immune pattern recognition receptorsPeripheral blood mononuclear cellsImmune pattern recognition receptorsCohort of HIVC-type lectin receptorsBlood mononuclear cellsMulticolor flow cytometryC-type lectin receptor MinclePattern recognition receptorsIL-10IL-12Cytokine productionIL-6Mononuclear cellsImmune responseHost responseCord factorFlow cytometryM. tuberculosisLectin receptorsMycobacterium tuberculosisOlder adultsImpact of aging
2013
Age-dependent dysregulation of innate immunity
Shaw AC, Goldstein DR, Montgomery RR. Age-dependent dysregulation of innate immunity. Nature Reviews Immunology 2013, 13: 875-887. PMID: 24157572, PMCID: PMC4096436, DOI: 10.1038/nri3547.Peer-Reviewed Original ResearchConceptsMetabolic syndromeIntracellular killingInnate immunityToll-like receptor functionNeutrophil extracellular trap formationBasal cytokine productionInnate immune dysregulationDendritic cell populationsMonocyte-derived DCsChronic viral infectionsMyeloid cells-1Pro-inflammatory milieuChronic inflammatory conditionsInnate immune activationVirus-infected macrophagesExtracellular trap formationAge-dependent dysregulationInnate immune systemPattern recognition receptorsAge-associated alterationsMacrophage colony-stimulating factorGranulocyte/macrophage colony-stimulating factorColony-stimulating factorTLR expressionImmune dysregulation