2023
Sampling from different populations: Sociodemographic, clinical, and functional differences between samples of first episode psychosis individuals and clinical high-risk individuals who progressed to psychosis
Hagler M, Ferrara M, Yoviene Sykes L, Li F, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Perkins D, Mathalon D, Seidman L, Tsuang M, Walker E, Powers A, Allen A, Srihari V, Woods S. Sampling from different populations: Sociodemographic, clinical, and functional differences between samples of first episode psychosis individuals and clinical high-risk individuals who progressed to psychosis. Schizophrenia Research 2023, 255: 239-245. PMID: 37028205, PMCID: PMC10207144, DOI: 10.1016/j.schres.2023.03.047.Peer-Reviewed Original ResearchMeSH KeywordsHumansLongitudinal StudiesNorth AmericaProdromal SymptomsProtective FactorsPsychotic DisordersConceptsFirst-episode psychosis servicesClinical high riskClinical high-risk individualsEarly detectionFirst-episode psychosis individualsRecent psychiatric hospitalizationCourse of illnessHigh-risk individualsAttenuated positive symptomsCHR researchGeographic catchmentSyndromal psychosisPsychosis individualsPsychiatric hospitalizationEarly intervention effortsHigh riskPsychosis servicesPositive symptomsGlobal functioningClinical resourcesProtective factorsDifferent populationsFE participantsGeneralizability of findingsFES program
2022
Accelerated cortical thinning precedes and predicts conversion to psychosis: The NAPLS3 longitudinal study of youth at clinical high-risk
Collins M, Ji J, Chung Y, Lympus C, Afriyie-Agyemang Y, Addington J, Goodyear B, Bearden C, Cadenhead K, Mirzakhanian H, Tsuang M, Cornblatt B, Carrión R, Keshavan M, Stone W, Mathalon D, Perkins D, Walker E, Woods S, Powers A, Anticevic A, Cannon T. Accelerated cortical thinning precedes and predicts conversion to psychosis: The NAPLS3 longitudinal study of youth at clinical high-risk. Molecular Psychiatry 2022, 28: 1182-1189. PMID: 36434057, PMCID: PMC10005940, DOI: 10.1038/s41380-022-01870-7.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentCerebral Cortical ThinningEthnicityFemaleHumansLongitudinal StudiesMaleMinority GroupsProdromal SymptomsPsychotic DisordersConceptsCHR-NCPercent thickness changeCortical thinningPsychosis onsetHealth controlsProgressive grey matter lossNorth American Prodrome Longitudinal StudyClinical high-risk individualsGray matter lossHigh-risk individualsLongitudinal studyGreater percent decreaseNovel treatment targetsParietal cortical regionsTargeted early interventionsCortical thicknessCortical areasMRI scansCHR individualsTreatment targetsEarly interventionCortical regionsLeft hemisphere regionsROC analysisHC participants
2019
Predictive validity of conversion from the clinical high risk syndrome to frank psychosis
Yoviene Sykes LA, Ferrara M, Addington J, Bearden CE, Cadenhead KS, Cannon TD, Cornblatt BA, Perkins DO, Mathalon DH, Seidman LJ, Tsuang MT, Walker EF, McGlashan TH, Woodberry KA, Powers AR, Ponce AN, Cahill JD, Pollard JM, Srihari VH, Woods SW. Predictive validity of conversion from the clinical high risk syndrome to frank psychosis. Schizophrenia Research 2019, 216: 184-191. PMID: 31864837, PMCID: PMC7239715, DOI: 10.1016/j.schres.2019.12.002.Peer-Reviewed Original ResearchConceptsFrank psychosisFirst-episode psychosis patientsOne-yearNorth American Prodromal Longitudinal StudySeverity of illnessClinical high-risk syndromeCurrent antipsychotic medicationsHigh-risk syndromePsychosis risk syndromeClinical high riskPredictive validityFEP casesPrescription ratesAntipsychotic medicationPsychosis patientsRisk syndromePsychosis onsetHigh riskLittle investigative attentionDiagnostic stabilityCHR individualsPsychosis paradigmPsychosisLongitudinal studySyndromeDuration of the psychosis prodrome
Powers AR, Addington J, Perkins DO, Bearden CE, Cadenhead KS, Cannon TD, Cornblatt BA, Mathalon DH, Seidman LJ, Tsuang MT, Walker EF, McGlashan TH, Woods SW. Duration of the psychosis prodrome. Schizophrenia Research 2019, 216: 443-449. PMID: 31806523, PMCID: PMC7539292, DOI: 10.1016/j.schres.2019.10.051.Peer-Reviewed Original ResearchConceptsSyndrome onsetPsychosis prodromeNorth American Prodrome Longitudinal StudyCHR-P patientsClinical high-risk syndromeHigh-risk syndromePsychosis risk syndromeMedication exposureProdromal periodFrank psychosisRisk syndromeProdromePsychosisLongitudinal studySyndromeOnsetStructured interviewsDurationFirst descriptionThirdYearsFinal thirdPatientsMonths