2023
Barriers and solutions to the adoption of translational tools for computational psychiatry
Benrimoh D, Fisher V, Mourgues C, Sheldon A, Smith R, Powers A. Barriers and solutions to the adoption of translational tools for computational psychiatry. Molecular Psychiatry 2023, 28: 2189-2196. PMID: 37280282, PMCID: PMC10611570, DOI: 10.1038/s41380-023-02114-y.Peer-Reviewed Original ResearchConceptsMainstream research directionIntegration of tasksComputational psychiatryComputational tasksComputational expertiseGame platformFormal modelDevelopment of tasksTaskLimited ecological validityResearch directionsEcological validityComputational methodsTest-retest reliabilityMore positive impactsInformation processingLarge-scale research projectProcessingHuman brainResearch project
2022
Conditioned Hallucinations and Prior Overweighting Are State-Sensitive Markers of Hallucination Susceptibility
Kafadar E, Fisher VL, Quagan B, Hammer A, Jaeger H, Mourgues C, Thomas R, Chen L, Imtiaz A, Sibarium E, Negreira AM, Sarisik E, Polisetty V, Benrimoh D, Sheldon AD, Lim C, Mathys C, Powers AR. Conditioned Hallucinations and Prior Overweighting Are State-Sensitive Markers of Hallucination Susceptibility. Biological Psychiatry 2022, 92: 772-780. PMID: 35843743, PMCID: PMC10575690, DOI: 10.1016/j.biopsych.2022.05.007.Peer-Reviewed Original ResearchConceptsCH rateIncoming sensory evidenceSensory evidencePerceptual statesTask performanceComputational psychiatrySubset of participantsPrior expectationsHallucination severityBehavioral dataSymptom severityPast experienceStable measureHallucinationsPsychotic symptomsHallucination frequencyTaskSymptom expressionBayesian modelState markerHallucinatorsNonhallucinatorsOverweightingPerceptionSymptom riskRelating Glutamate, Conditioned, and Clinical Hallucinations via 1H-MR Spectroscopy
Leptourgos P, Bansal S, Dutterer J, Culbreth A, Powers A, Suthaharan P, Kenney J, Erickson M, Waltz J, Wijtenburg SA, Gaston F, Rowland LM, Gold J, Corlett P. Relating Glutamate, Conditioned, and Clinical Hallucinations via 1H-MR Spectroscopy. Schizophrenia Bulletin 2022, 48: 912-920. PMID: 35199836, PMCID: PMC9212089, DOI: 10.1093/schbul/sbac006.Peer-Reviewed Original ResearchConceptsGlutamate levelsAnterior insulaPrior beliefsCognitive modelPathophysiological theoriesAuditory cortexClinical hallucinationsAnterior cingulateComputational psychiatryNew treatmentsDorsolateral prefrontalVisual cuesPrior expectationsSame participantsHallucinationsInsulaNegative relationshipCurrent experienceMagnetic resonance spectroscopyBeliefsComputational modelingTone