2021
Heterogeneous development of children with Congenital Zika Syndrome-associated microcephaly
Ticona J, Nery N, Doss-Gollin S, Gambrah C, Lessa M, Rastely-Júnior V, Matos A, de Paula Freitas B, Borja A, Wunder EA, Ballalai V, Vieira C, Cruz JS, de Oliveira D, Araujo DB, Oliveira DB, Maeda D, Mendes EA, Soares C, Durigon EL, de Souza Ferreira LC, Belfort R, Almeida A, Oliveira-Filho J, Reis MG, Ko AI, Costa F. Heterogeneous development of children with Congenital Zika Syndrome-associated microcephaly. PLOS ONE 2021, 16: e0256444. PMID: 34525107, PMCID: PMC8443077, DOI: 10.1371/journal.pone.0256444.Peer-Reviewed Original ResearchConceptsCongenital Zika syndromeHammersmith Infant Neurological ExaminationHINE scoresZika syndromeHead circumferenceBayley-IIILong-term outcomesGreater head circumferenceSevere developmental delayYears of ageSevere neurodevelopmental delayToddler neurodevelopmentNeurological evaluationMedian ageNeurodevelopmental outcomesNeurological examinationMultivariable analysisNeurodevelopmental assessmentOutpatient clinicNeurodevelopmental evaluationNeurodevelopmental delayBayley ScalesNeurodevelopmental profileSevere microcephalyMild delayDevelopmental outcomes in children exposed to Zika virus in utero from a Brazilian urban slum cohort study
Ticona J, Nery N, Ladines-Lim JB, Gambrah C, Sacramento G, de Paula Freitas B, Bouzon J, Oliveira-Filho J, Borja A, Adhikarla H, Montoya M, Chin A, Wunder EA, Ballalai V, Vieira C, Belfort R, Almeida A, Reis MG, Harris E, Ko AI, Costa F. Developmental outcomes in children exposed to Zika virus in utero from a Brazilian urban slum cohort study. PLOS Neglected Tropical Diseases 2021, 15: e0009162. PMID: 33544730, PMCID: PMC7891708, DOI: 10.1371/journal.pntd.0009162.Peer-Reviewed Original ResearchConceptsPopulation attributable fractionZIKV exposureMonths of ageMild cognitive delayZika virus exposureZIKV-exposed childrenPopulation-based cohortCognitive delayDevelopmental alterationsMonoclonal antibody blockadeMonths of lifeGross birth defectsAppropriate control groupsProspective serosurveyCohort studyNeurodevelopmental outcomesAntibody blockadeNeurodevelopmental evaluationVirus exposureAttributable fractionBehavioral abnormalitiesControl groupRest of womenZika virusCohort
2019
Seroprevalence, Risk Factors, and Rodent Reservoirs of Leptospirosis in an Urban Community of Puerto Rico, 2015
Briskin EA, Casanovas-Massana A, Ryff KR, Morales-Estrada S, Hamond C, Perez-Rodriguez NM, Benavidez KM, Weinberger DM, Castro-Arellano I, Wunder EA, Sharp TM, Rivera-Garcia B, Ko AI. Seroprevalence, Risk Factors, and Rodent Reservoirs of Leptospirosis in an Urban Community of Puerto Rico, 2015. The Journal Of Infectious Diseases 2019, 220: 1489-1497. PMID: 31342075, PMCID: PMC6761939, DOI: 10.1093/infdis/jiz339.Peer-Reviewed Original ResearchConceptsRisk factorsAnti-Leptospira antibodiesBurden of leptospirosisRisk of infectionMicroscopic agglutination testCross-sectional surveyQuantitative polymerase chain reactionSeropositive individualsPrevious infectionPolymerase chain reactionLeptospira infectionLeptospira carriageSerogroup IcterohaemorrhagiaeHigh titersStudy participantsAgglutination testLeptospira exposurePathogenic LeptospiraInfectionRodent reservoirsChain reactionAntibodiesRodent trappingSeroprevalenceCommunity sites
2000
Clonally Related Penicillin-Nonsusceptible Streptococcus pneumoniae Serotype 14 from Cases of Meningitis in Salvador, Brazil
Ko A, Reis J, Coppola S, Gouveia E, Cordeiro S, Lôbo T, Pinheiro R, Salgado K, Dourado C, Tavares-Neto J, Rocha H, Reis M, Johnson W, Riley L. Clonally Related Penicillin-Nonsusceptible Streptococcus pneumoniae Serotype 14 from Cases of Meningitis in Salvador, Brazil. Clinical Infectious Diseases 2000, 30: 78-86. PMID: 10619737, DOI: 10.1086/313619.Peer-Reviewed Original ResearchConceptsPenicillin-nonsusceptible isolatesSerotype 14 isolatesSerotype 14Pneumococcal meningitisActive hospital-based surveillanceCases of meningitisHospital-based surveillancePrevious antibiotic useIntermediate-level resistanceSerotype 14 strainsPolymerase chain reaction analysisAntibiotic useChain reaction analysisPrevalent serotypesMeningitisUnrelated patternsPCR patternsCity of SalvadorPatientsStreptococcus pneumoniae serotype 14Reaction analysisIsolatesLarge proportionGeographic areasInfection