Seroepidemiology of Leptospira infection in slaughtered cattle in Gauteng province, South Africa
Dogonyaro BB, van Heerden H, Potts AD, Kolo BF, Lotter C, Katsande C, Fasina FO, Ko AI, Wunder EA, Adesiyun AA. Seroepidemiology of Leptospira infection in slaughtered cattle in Gauteng province, South Africa. Tropical Animal Health And Production 2020, 52: 3789-3798. PMID: 33009586, PMCID: PMC10407966, DOI: 10.1007/s11250-020-02417-0.Peer-Reviewed Original ResearchConceptsSeroprevalence of leptospirosisMicroscopic agglutination testRisk factorsCattle populationSeropositive cattleSerogroup SejroeSouth AfricaCattleCross-sectional studyLeptospira sppPublic health importancePredominant serogroupVaccine serogroupsAbattoirLivestockLeptospira infectionGauteng ProvinceCutoff titerBlood samplesLeptospirosisSejroeDemographic dataHealth importanceAgglutination testSeroprevalenceEscape of TLR5 Recognition by Leptospira spp.: A Rationale for Atypical Endoflagella
Holzapfel M, Bonhomme D, Cagliero J, Vernel-Pauillac F, d’Andon M, Bortolussi S, Fiette L, Goarant C, Wunder EA, Picardeau M, Ko AI, Werling D, Matsui M, Boneca IG, Werts C. Escape of TLR5 Recognition by Leptospira spp.: A Rationale for Atypical Endoflagella. Frontiers In Immunology 2020, 11: 2007. PMID: 32849665, PMCID: PMC7431986, DOI: 10.3389/fimmu.2020.02007.Peer-Reviewed Original ResearchConceptsTLR5 recognitionHuman Toll-like receptorsTLR5-deficient miceToll-like receptorsInnate immune recognitionNOD-like receptorsBacterial cell wall componentsHeat-killed bacteriaInflammatory roleDeficient miceTLR5 activationImmune responseLive leptospiresTLR5Immune recognitionLive strainsStealth pathogenWorldwide zoonosisHost defenseBovine TLR5TLR5 activityLeptospira sppInfectionLeptospiresCentral localization