Effects of Accounting for Interval-Censored Antibody Titer Decay on Seroincidence in a Longitudinal Cohort Study of Leptospirosis
Bonner K, Cruz JS, Sacramento GA, de Oliveira D, Nery N, Carvalho M, Costa F, Childs JE, Ko AI, Diggle PJ. Effects of Accounting for Interval-Censored Antibody Titer Decay on Seroincidence in a Longitudinal Cohort Study of Leptospirosis. American Journal Of Epidemiology 2020, 190: 893-899. PMID: 33274738, PMCID: PMC8096484, DOI: 10.1093/aje/kwaa253.Peer-Reviewed Original ResearchConceptsLongitudinal cohort studyCohort studyMicroscopic agglutination test titersAgglutination test titersHigh transmission settingsPoint-source exposureSeroincidence ratesEstimates of infectionRisk factorsTest titersReported casesEpidemiologic implicationsInfection rateMean infection rateSerological samplesSerological assaysLeptospirosis casesInfectionArboviral diseasesTiter dilutionsSeroincidenceSource exposureLeptospirosisSample size estimationInterval