2021
PD-L1 (Programmed Death Ligand 1) Regulates T-Cell Differentiation to Control Adaptive Venous Remodeling
Matsubara Y, Gonzalez L, Kiwan G, Liu J, Langford J, Gao M, Gao X, Taniguchi R, Yatsula B, Furuyama T, Matsumoto T, Komori K, Mori M, Dardik A. PD-L1 (Programmed Death Ligand 1) Regulates T-Cell Differentiation to Control Adaptive Venous Remodeling. Arteriosclerosis Thrombosis And Vascular Biology 2021, 41: 2909-2922. PMID: 34670406, PMCID: PMC8664128, DOI: 10.1161/atvbaha.121.316380.Peer-Reviewed Original ResearchConceptsPD-L1AVF maturationPD-L1 activityVenous remodelingT cellsL1 antibodyArteriovenous fistulaNude miceMouse aortocaval fistula modelEnd-stage renal diseaseT helper type 2 cellsT helper type 1 (Th1) cellsPrimary success rateSmooth muscle cell proliferationRegulatory T cellsT cell activityT-cell transferAortocaval fistula modelPreferred vascular accessVascular wall thickeningM1-type macrophagesM2-type macrophagesPotential therapeutic targetMuscle cell proliferationType 1 cells
1999
Neutralizing TGF-β1 antibody infusion in neonatal rat delays in vivo glomerular capillary formation 1 1 See Editorial by Abrahamson, p. 1597
Liu A, Dardik A, Ballermann B. Neutralizing TGF-β1 antibody infusion in neonatal rat delays in vivo glomerular capillary formation 1 1 See Editorial by Abrahamson, p. 1597. Kidney International 1999, 56: 1334-1348. PMID: 10504486, DOI: 10.1046/j.1523-1755.1999.00661.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBinding, CompetitiveCapillariesCell DifferentiationEndothelial Growth FactorsEndothelium, VascularFemaleImmunoglobulin GInjections, Intra-ArterialIodine RadioisotopesKidney GlomerulusLymphokinesMicroinjectionsMicroscopy, ElectronNephronsNeutralization TestsPregnancyRatsRats, Sprague-DawleyTime FactorsTransforming Growth Factor betaVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsVon Willebrand Factor