2024
Abstract 3143: Computational Modeling Of Non-homeostatic Changes Within An Arterial-venous Fistula System Using In Vivo Validation To Understand Mechanical Causes Of Fistula Failure
Varsanik M, Thaxton C, Li W, Dardik A, Pocivavsek L. Abstract 3143: Computational Modeling Of Non-homeostatic Changes Within An Arterial-venous Fistula System Using In Vivo Validation To Understand Mechanical Causes Of Fistula Failure. Arteriosclerosis Thrombosis And Vascular Biology 2024, 44 DOI: 10.1161/atvb.44.suppl_1.3143.Peer-Reviewed Original ResearchArteriovenous fistulaFistula failureNeointimal hyperplasiaLong-term dialysis accessFistula systemClinical problemEnd stage renal patientsPresence of arteriovenous fistulaStatic pressureArteriovenous fistula failureCT angiography scansMurine AVF modelStenotic veinsVenous stenosisAngiography scansStatic pressure peakDialysis accessFistulaAnesthetized miceRenal patientsVenous velocityFistula modelIn vivo validationHigh static pressureNative veins
2022
Endothelial Cell TGF-β (Transforming Growth Factor-Beta) Signaling Regulates Venous Adaptive Remodeling to Improve Arteriovenous Fistula Patency
Taniguchi R, Ohashi Y, Lee JS, Hu H, Gonzalez L, Zhang W, Langford J, Matsubara Y, Yatsula B, Tellides G, Fahmy TM, Hoshina K, Dardik A. Endothelial Cell TGF-β (Transforming Growth Factor-Beta) Signaling Regulates Venous Adaptive Remodeling to Improve Arteriovenous Fistula Patency. Arteriosclerosis Thrombosis And Vascular Biology 2022, 42: 868-883. PMID: 35510552, PMCID: PMC9233042, DOI: 10.1161/atvbaha.122.317676.Peer-Reviewed Original ResearchConceptsArteriovenous fistulaSMC proliferationAVF patencyCollagen densityMouse aortocaval fistula modelTGF-β receptor IArteriovenous fistula patencyAortocaval fistula modelInhibition of TGFPredetermined time pointsTGF-β inhibitionTGF-β signalingTGF-β receptorDisruption of TGFFistula patencyAVF failureWall thicknessVascular accessVenous remodelingSuccessful hemodialysisDoppler ultrasoundFistula modelReceptor IPatencyTGF
2020
Artery to vein configuration of arteriovenous fistula improves hemodynamics to increase maturation and patency
Bai H, Sadaghianloo N, Gorecka J, Liu S, Ono S, Ramachandra AB, Bonnet S, Mazure NM, Declemy S, Humphrey JD, Dardik A. Artery to vein configuration of arteriovenous fistula improves hemodynamics to increase maturation and patency. Science Translational Medicine 2020, 12 PMID: 32817365, PMCID: PMC7705473, DOI: 10.1126/scitranslmed.aax7613.Peer-Reviewed Original ResearchConceptsArteriovenous fistulaHemodialysis accessNeointimal hyperplasiaEndothelial nitric oxide synthaseDurable surgical optionUremic male ratsRadial-cephalic arteriovenous fistulaKruppel-like factor 2Nitric oxide synthasePeak systolic velocityLong-term patencyReintervention rateSecondary patencyImproved hemodynamicsFemale patientsReimplantation techniqueSurgical optionsSystolic velocityMale ratsOxide synthaseFistula modelPatencyHemodynamicsDifferent hemodynamicsFemale animals