Colocalization of transforming growth factor-α and a functional epidermal growth factor receptor (EGFR) to the inner cell mass and preferential localization of the EGFR on the basolateral surface of the trophectoderm in the mouse blastocyst
Dardik A, Smith R, Schultz R. Colocalization of transforming growth factor-α and a functional epidermal growth factor receptor (EGFR) to the inner cell mass and preferential localization of the EGFR on the basolateral surface of the trophectoderm in the mouse blastocyst. Developmental Biology 1992, 154: 396-409. PMID: 1426645, DOI: 10.1016/0012-1606(92)90078-u.Peer-Reviewed Original ResearchConceptsEpidermal growth factor receptorFunctional epidermal growth factor receptorTGF-alphaAnti-EGFR antibodiesGrowth factor receptorParacrine roleBasolateral surfaceInner cell massCell massPotential autocrineMouse blastocystsGrowth factorFactor receptorImmunoelectron microscopy studiesReceptorsBlastocyst developmentTE cellsOvernight cultureEGF treatmentPolar trophectodermEGF receptorMouse preimplantation embryosBlastocystsAcid-insoluble materialEGFChanges in camp phosphodiesterase activity and cAMP concentration during mouse preimplantation development
Dardik A, Schultz R. Changes in camp phosphodiesterase activity and cAMP concentration during mouse preimplantation development. Molecular Reproduction And Development 1992, 32: 349-353. PMID: 1323307, DOI: 10.1002/mrd.1080320407.Peer-Reviewed Original ResearchConceptsTGF-alpha/EGFMid-blastocyst stageBlastocoel expansionBlastocyst stageMouse preimplantation developmentMouse preimplantation embryosTGF-alphaPreimplantation developmentCAMP concentrationCell shapePreimplantation embryosElevation of cAMPCell typesPhosphodiesterase activityEmbryo volumeIntracellular volumeEmbryosCAMP levelsEGF