2023
Treatment of intramedullary spinal cord tumors: a modified Delphi technique of the North American Spine Society Section of Spine Oncology.
Hersh A, Pennington Z, Lubelski D, Elsamadicy A, Dea N, Desai A, Gokaslan Z, Goodwin C, Hsu W, Jallo G, Krishnaney A, Laufer I, Lo S, Macki M, Mehta A, Ozturk A, Shin J, Soliman H, Sciubba D. Treatment of intramedullary spinal cord tumors: a modified Delphi technique of the North American Spine Society Section of Spine Oncology. Journal Of Neurosurgery Spine 2023, 40: 1-10. PMID: 37856379, DOI: 10.3171/2023.8.spine23190.Peer-Reviewed Original ResearchConceptsIntramedullary spinal cord tumorsSpinal cord tumorsTumor-specific characteristicsOperative candidacyCord tumorsResection strategyNew neurological deficitsGross total resectionT2 signal changeSet of patientsAreas of controversyIMSCT resectionFrail patientsChronic myelopathyChronic paraplegiaNeurological deficitsPreoperative symptomsTranscranial motorDelphi techniqueSurgical managementMild numbnessOperative managementSurgical interventionFurther resectionRare tumor
2021
Hypermutated phenotype in gliosarcoma of the spinal cord
Hong CS, Kuzmik GA, Kundishora AJ, Elsamadicy AA, Koo AB, McGuone D, Blondin NA, DiLuna ML, Erson-Omay EZ. Hypermutated phenotype in gliosarcoma of the spinal cord. Npj Precision Oncology 2021, 5: 8. PMID: 33580181, PMCID: PMC7881101, DOI: 10.1038/s41698-021-00143-w.Peer-Reviewed Original ResearchSpinal cordWhole-exome sequencingLow-grade brain gliomasVariant of glioblastomaLow-grade gliomasTumor anteriorAdjuvant radiationNeurological deficitsSomatic single nucleotide variationsPoor prognosisGrade gliomasTemozolomide treatmentBrain gliomasGliosarcomaMicrosatellite stabilityCordSomatic mutationsHypermutator phenotypeGliomasComprehensive genetic characterizationGenomic mechanismsSingle nucleotide variationsPhenotypeFirst reportPathway genes
2017
Leptomeningeal disease: current diagnostic and therapeutic strategies
Nayar G, Ejikeme T, Chongsathidkiet P, Elsamadicy AA, Blackwell KL, Clarke JM, Lad SP, Fecci PE. Leptomeningeal disease: current diagnostic and therapeutic strategies. Oncotarget 2017, 5: 73312-73328. PMID: 29069871, PMCID: PMC5641214, DOI: 10.18632/oncotarget.20272.Peer-Reviewed Original ResearchLeptomeningeal diseaseT1-weighted magnetic resonance imagingCerebrospinal fluid cytologyLate-stage complicationsNovel therapeutic interventionsMagnetic resonance imagingLeptomeningeal spreadMedian survivalNeurological deficitsPrimary malignancyObstructive hydrocephalusSystemic diseaseCancer patientsLung cancerTreatment modalitiesFluid cytologyBreast cancerRadiation therapyTherapeutic strategiesTherapeutic interventionsMalignant cellsResonance imagingYounger ageEarly detectionDisease