2023
Global Burden of Cardiovascular Diseases and Risks, 1990-2022
Mensah G, Fuster V, Murray C, Roth G, Collaborators G, Mensah G, Abate Y, Abbasian M, Abd-Allah F, Abdollahi A, Abdollahi M, Abdulah D, Abdullahi A, Abebe A, Abedi A, Abedi A, Abiodun O, Ali H, Abu-Gharbieh E, Abu-Rmeileh N, Aburuz S, Abushouk A, Abu-Zaid A, Adane T, Adderley N, Adebayo O, Aden B, Adeyeoluwa T, Adeyomoye O, Adnani Q, Afrashteh F, Afyouni S, Afzal S, Agasthi P, Agodi A, Arriagada C, Agyemang-Duah W, Ahinkorah B, Ahmad A, Ahmad D, Ahmad F, Ahmad M, Ahmed A, Ahmed H, Ahmed M, Ahmed S, Ajami M, Akinosoglou K, Ala M, AL-Ahdal T, Alalalmeh S, Al-Aly Z, Alam N, Al-amer R, Alashi A, Albashtawy M, AlBataineh M, Alema H, Alemi S, Alemu Y, Al-Gheethi A, Alhabib K, Alhalaiqa F, Ali M, Ali R, pursuing, Ali S, Alicandro G, Alikhani R, Aljunid S, Alla F, Almahmeed W, Al-Marwani S, Alonso J, Al-Raddadi R, Alvi F, Alvis-Guzman N, Alvis-Zakzuk N, Alwafi H, Aly H, Amegbor M, Amin T, Amindarolzarbi A, Amini-Rarani M, Amiri S, Ammirati E, Anand T, Ancuceanu R, Anderlini D, Anil A, Ansari G, Anyanwu P, Anyasodor A, Apostol G, Arabloo J, Arafat M, Aravkin A, Aremu O, Armocida B, Ärnlöv J, Arowosegbe O, Artamonov A, Artanti K, Arulappan J, Aruleba I, Arumugam A, Aryan Z, Asghari-Jafarabadi M, Astell-Burt T, Ataei M, Athar M, Atreya A, Aujayeb A, Awotidebe A, Aynalem A, Azizi Z, Azzam A, Babu A, Badar M, Bader F, Badiye A, Bagga A, Bagherieh S, Asl F, Bai R, Baker J, Bakkannavar S, Bako A, Bakshi R, Balogun S, Baltatu O, Bam K, Banach M, Bandyopadhyay S, Banik B, Banik P, Bansal K, Baradaran H, Barbic F, Barchitta M, Bardhan M, Barker-Collo S, Bärnighausen T, Barone-Adesi F, Barteit S, Barua L, Bashiri A, Bayati M, Bayileyegn N, Behboudi E, Behnoush A, Béjot Y, Belay S, Belete M, Belgaumi U, Bell M, Belo L, Bendak S, Benfor B, Bennett D, Bensenor I, Benziger C, Beran A, Berman A, Bermudez A, Bertolacci G, Beyene H, Beyene K, Bhagavathula A, Bhardwaj N, Bhardwaj P, Bhardwaj P, Bhat V, Bhatti G, Bhatti J, Bikbov B, Bikov A, Birck M, Biswas B, Bitaraf S, Bodunrin A, Bogale E, Bogale K, Boloor A, Hashemi M, Borhany H, Boyko E, Braithwaite D, Brant L, Brauer M, Breitner S, Briko A, Bulto L, Bustanji Y, Butt Z, Calina D, Cao F, Cárdenas R, Carr S, Carreras G, Carrero J, Carvalho M, Castaldelli-Maia J, Castañeda-Orjuela C, Cegolon M, Cerin E, Chahine Y, Chan J, Chan M, Chan R, Charalampous P, Charan J, Chattu V, Chen A, Chen C, Chen H, Chennapragada S, Chew D, Chi G, Ching P, Chitheer A, Cho S, Cho W, Chong B, Chopra H, Choudhary R, Chowdhury E, Chowdhury R, Chu D, Chukwu I, Cicero A, Cindi Z, Cioffi I, Coberly K, Coffey S, Columbus A, Conde J, Conti S, Corso B, Cortés S, Cortesi P, Costa V, Couto R, Cowart E, Criqui M, Cruz J, Dadana S, Dadras O, Dai X, Dai Z, Dalaba M, Damasceno A, Damiani G, D'Amico E, Das S, Das S, Dashti M, Dashtkoohi M, Dastmardi M, Davletov K, Debele A, Debopadhaya S, DeCleene N, Delgado-Enciso I, Delgado-Saborit J, Demessa B, Demetriades A, Deng X, Denova-Gutiérrez E, Dereje N, Derese A, Desai H, Desai R, Devanbu V, Dewan S, Dey S, Dhulipala V, Diaz D, Diaz M, Ding D, Dinis-Oliveira R, Chi T, Phuong T, Doaei S, Dohare S, Dong W, D'Oria M, dos Santos W, Douiri A, Dowou R, Dsouza A, Dsouza H, Dsouza V, Du M, Duraes A, Durojaiye O, Dutta S, Dziedzic A, Ebrahimi A, Efendi D, Efendi F, Effendi D, Eini E, Ekholuenetale M, Ekundayo T, Sayed I, Tantawi M, Elbarazi I, Elgar F, Elgendy I, Elhadi M, El-Huneidi W, Emamverdi M, Emeto T, Erkhembayar R, Eshetie T, Espinosa-Montero J, Etaee F, Fabin N, Fadhil I, Fagbamigbe A, Falzone L, Farinha C, Faris M, Faro A, Faruque M, Farwati M, Fasanmi A, Fatehizadeh A, Fazeli P, Feigin V, Feng X, Fereshtehnejad S, Feroze A, Ferrara P, Ferreira N, Filip I, Fleszar L, Flood D, Folayan M, Fomenkov A, Fonseca D, Fornari C, Foschi M, Franklin R, Fukumoto T, BlimaFux, Gaal P, Gadanya M, Gaidhane S, Gaipov A, Gakidou E, Galali Y, Gallus S, Gandhi A, Ganesan B, Gautam R, Gebregergis M, Gebrekidan K, Geleijnse J, Gerema U, Ghajar A, Ghamari S, Ghasemi M, Dabaghi G, Ghasemzadeh A, Ghazy R, Gholamalizadeh M, Ghuge A, Gill P, Gill T, Gillum R, Gnedovskaya E, Golchin A, Goleij P, Gorini G, Goulart A, Goyal A, Goyal K, Guan S, Guarducci G, Gudeta M, Guha A, Guicciardi S, Gulisashvili D, Gunawardane D, Guo C, Gupta A, Gupta B, Gupta I, Gupta K, Gupta M, Gupta R, Gupta R, Gupta R, Gupta S, Gupta V, Gupta V, Gupta V, Gurmessa L, Gutiérrez R, Habibzadeh F, Hadei M, Boroojeni H, Halimi A, Haller S, Halwani R, Hamadeh R, Hamdy N, Hamidi S, Han C, Han Q, Hankey G, Hannan A, Hargono A, Haro J, Hasan F, Hasan I, Hasani H, Hashemian M, Hasnain S, Hassan A, Hassan I, Haubold J, Havmoeller R, Hay S, Hayat K, Hbid Y, Hegazi O, Hegena T, Heidari M, Helfer B, Herrera-Serna B, Herteliu C, Hesami H, Hessami K, Heydari K, Hezam K, Hiraike Y, Hoan N, Holla R, Hossain M, Hossain B, Hosseinzadeh H, Hosseinzadeh M, Hostiuc M, Hostiuc S, Hsairi M, Huang J, Hultström M, Huynh H, Hwang B, Ibrahim K, Idowu O, Ilesanmi O, Ilic I, Ilic M, Immurana M, Inbaraj L, Iqhrammullah M, Islam M, Ismail F, Ismail N, Isola G, Iwagami M, J L, Jaafari J, Jacob L, Jafarzadeh A, Jaggi K, Jahrami H, Jain A, Jain N, Jairoun A, Jakovljevic M, Jamora R, Javadi N, Jayapal S, Jayaram S, Jebai R, Jeben R, Jee S, Jha A, Jha R, Jha V, Jiang H, Jin Y, Jobanputra Y, Johnson C, Jokar M, Joo T, Joseph A, Joseph N, Joshua C, Jozwiak J, Jürisson M, Kabir A, Kabir Z, Kadashetti V, Kahe F, Kalani R, Kalankesh L, Kalantar F, Kalkonde Y, Kalra S, Kamath A, Kamath S, Kamireddy A, Kanchan T, Kandel H, Kanmanthareddy A, Kanmodi K, Kansal S, Kapner D, Kar S, Karakasis P, Karki P, Kashoo F, Kasraei H, Kassahun E, Kassebaum N, Katoto P, Kaydi N, Kazemi F, Kazemian S, Kazeminia S, Kerr J, Kesse-Guyot E, Keykhaei M, Khadembashiri M, Khadembashiri M, Khafaie M, Khajuria H, Khalaji A, Khalid N, Khalilian A, Khalilov R, Khan A, Khan E, Khan J, Khan M, Khan M, Khan M, Khan M, Khan Y, suheb M, Khanmohammadi S, Khatab K, Khateri S, Kashani H, Kheirallah K, Khidri F, Kian S, Kifle Z, Kimokoti R, Kisa A, Kisa S, Kolahi A, Kompani F, Koren G, Kotnis A, Koul P, Koyanagi A, Krishan K, Krishna H, Krishnamoorthy V, Krishnamoorthy Y, Kuddus A, Kuddus M, Kulimbet M, Kulkarni V, Kumar A, Kumar A, Kumar N, Kumar N, Kumar R, Kumsa N, Kunle K, Kusuma D, Kyriopoulos I, La Vecchia C, Lacey B, Ladan M, Laflamme L, Lahariya C, Lahiri A, Lai D, Lallukka T, Lan Q, Landires I, Lanfranchi F, Larijani B, Larsson A, Lasrado S, Epidemiology K, Latifinaibin K, Lau J, Lauriola P, Le K, Le L, Le N, Le T, Le T, Le T, Ledda C, Lee M, Lee P, Lee S, Lee W, Lee Y, LeGrand K, Leinsalu M, Leonardi M, Lerango T, Li A, Li M, Li W, Li X, Li Y, Lim L, Lim S, Lin R, Lindstrom M, Linn S, Liu G, Liu S, Liu X, Liu X, Livingstone K, Llanaj E, Lopukhov P, Cand of Sci, Loreche A, Lorenzovici L, Lorkowski S, Lotufo P, Lucchetti G, Lugo A, Feei Z, Madadizadeh F, Maddison R, Gómez J, Magne J, Prasad D, Mahalleh M, Mahmoud M, Mahmoudi E, Mahmoudvand B, Makram O, Rad E, Malekzadeh R, Malhotra K, Malik I, Malik M, Mallhi T, Malta D, Manilal A, Manla Y, Mansoori Y, Mansouri B, Mansouri P, Mansournia M, Marateb H, Marino M, Martini D, Martini S, Maryam S, Marzo R, Masoudi A, Masoudi S, Matei C, Mathangasinghe Y, Mathews E, Mathur M, Mattumpuram J, Maude R, Maugeri A, Mayeli M, Mazidi M, McGrath J, McPhail S, Mechili E, Medina J, Meena J, Mehrabani-Zeinabad K, Mendez-Lopez M, Mendoza W, Menezes R, Mengist B, Meo A, Meresa H, Meretoja A, Meretoja T, Mestrovic T, Mettananda K, Mettananda S, Mhlanga L, Mi T, Jonasson J, Miazgowski T, Michalek I, Miller T, Minh L, Minja N, Sadeghi P, Mirdamadi N, Mirica A, Mirrakhimov E, Mirza M, Mirza-Aghazadeh-Attari M, Mithra P, Moghimi Z, Mohamed J, Mohamed M, Mohamed N, Mohammadi S, Mohammed H, Mohammed M, Mohammed S, Mohammed S, Moka N, Mokdad A, Vardanjani H, Momtazmanesh S, Monasta L, Montazeri F, Ghalibaf A, Moradi Y, Moraga P, Morawska L, Morovatdar N, Morrison S, Morze J, Mostafavi E, Mostofinejad A, Mougin V, Mousavi P, Mousavi S, Mozaffarian D, Msherghi A, Muccioli L, Mueller U, Mukherjee S, Munjal K, Murillo-Zamora E, Mustafa G, Muthu S, Mwita J, Myung W, Nagarajan A, Nagaraju S, Naik G, Naik G, Nair T, Najafi M, Ansari N, Nangia V, Swamy S, Nargus S, Nascimento B, Nascimento G, Nasoori H, Natto Z, Nauman J, Naveed M, Nayak B, Nayak V, Negash H, Negoi I, Negoi R, Abadi R, Nejadghaderi S, Nejjari C, Nematollahi M, Nepal S, Ng N, Nguyen D, Nguyen P, Nguyen V, Niazi R, Nijjar S, Nizam M, Noman E, Nomura S, Noreen M, Norrving B, Noubiap J, Nri-Ezedi C, Ntsekhe M, Nurrika D, Nzoputam C, Nzoputam O, Obamiro K, O'Donnell M, Oghenetega O, Oguntade A, Oguta J, Okeke S, Okekunle A, Okidi L, Okonji O, Okwute P, Olagunju A, Olaiya M, Olana M, Olatubi M, Oliveira G, Olorukooba A, Olufadewa I, Oluwafemi Y, Oluwatunase G, Omer G, Ommati M, Ong K, Ong S, Onyedibe K, Ordak M, Ortega-Altamirano D, Ortiz A, Ortiz-Prado E, Osman W, Osuagwu U, Otoiu A, Otstavnov S, Owolabi M, A M, Padron-Monedero A, Padubidri J, Varnosfaderani M, Palicz T, Palladino R, Pan F, Pan H, Pandi-Perumal S, Papadopoulou P, Park S, Passera R, Patel J, Patil S, Patoulias D, Patthipati V, Pawar S, Peden A, Pedersini P, Peng M, Pepito V, Peprah E, Pereira M, Pereira M, Peres M, Perianayagam A, Perico N, Petermann-Rocha F, Pham H, Philip A, Pigott D, Pilgrim T, Piradov M, Plotnikov E, Poddighe D, Polibin R, Poluru R, Pourali G, Pourshams A, Pradhan P, Prasad M, Prates E, Purohit B, Puvvula J, Qattea I, Qian G, Qureshi M, rad M, Radfar A, Alavi S, Rafique I, Raggi A, Rahim F, Rahim J, Rahimi M, Rahman M, Rahman M, Rahmani A, Rahmani B, Rahmani S, Rahmanian V, Rai P, Rajaa S, Rajabpour-Sanati A, Rajput P, Ram P, Ram P, Ramalingam S, Ramasamy S, Ramazanu S, Ramesh P, Rana J, Rana K, Ranabhat C, Rancic N, Rane A, Ranjan S, Ranta A, Rao I, Rao M, Rao S, Rashedi S, Rashedi V, Rashid A, Rasul A, Ratan Z, Babu G, Ravikumar N, Rawaf S, Razeghian-Jahromi I, Razo C, Reddy M, Redwan E, Remuzzi G, Reyes L, Rezaei N, Rezaeian M, Ribeiro A, Ribeiro D, Rikhtegar R, Roever L, Romadlon D, Ronfani L, Rout H, Roy N, Roy P, Rynkiewicz A, Saad A, Saadatian Z, Sabour S, Sacco S, Sachdeva R, Saddik B, Sadeghi E, Saeed U, Safaeinejad F, Sharif-Askari F, Sharif-Askari N, Sahebkar A, Sahoo S, Sajedi S, Sajid M, Sakshaug J, Salam N, Salami A, Saleh M, Salehi S, Salem M, Salem M, Samadzadeh S, Samargandy S, Samuel V, Samy A, Sanabria J, Sanjeev R, Santric-Milicevic M, Saqib M, Sarasmita M, Saravanan A, Sarikhani Y, Sarkar T, Sarmiento-Suárez R, Sarode G, Sarode S, Sathish T, Sathyanarayan A, Sawhney M, Sayyah M, Scarmeas N, Schaarschmidt B, Schuermans A, Schumacher A, Schutte A, Schwebel D, Sedighi M, Seidu A, Semnani F, Senapati S, Sengupta P, Senthilkumaran S, Sepanlou S, Sethi Y, Seyedi S, Seylani A, Shabany M, Shafeghat M, Shafie M, Shah P, Shahbandi A, Shahid I, Shahid S, Shahid W, Shahwan M, Shaikh M, Sham S, Shamim M, Shanawaz M, Sharfaei S, Sharifan A, Sharifi-Rad J, Sharma P, Sharma S, Sharma U, Sharma V, Sheikh A, Shiferaw D, Shigematsu M, Shin M, Shiri R, Shishani K, Shittu A, Shiue I, Shivakumar K, Shrestha S, Shuval K, Sibhat M, Sigfusdottir I, Simpson C, Singh A, Singh A, Singh A, Singh J, Singh P, Singh R, Singh S, Siraj S, Skryabin V, Skryabina A, Sleet D, Soleimani H, Solikhah S, Soliman S, Son J, Song S, Song Y, Soriano J, Spartalis M, Sreeramareddy C, Stafford L, Stark B, Steiropoulos P, Stortecky S, Abdulkader R, Sultana A, Sundström J, Swain C, Damavandi P, Tabatabaei S, Malazy O, Tabatabaeizadeh S, Tabatabai S, Tabb K, Tabish M, Tabuchi T, Tadese F, Abkenar Y, Taiba J, Talaat I, Tampa M, Tamuzi J, Tan K, Tang H, Tarkang E, Tat N, Tavangar S, Tehrani H, Teimoori M, Temsah M, Temsah R, Teramoto M, Thangaraju P, Thankappan K, Thapa R, Thapar R, Thavamani A, Thayakaran R, Thomas N, Tian J, Tichopad A, Tillawi T, Tonelli M, Topor-Madry R, Touvier M, Tovani-Palone M, Tran J, Tran N, Van Tran P, Trihandini I, Tripathi A, Tromans S, Truong V, Truyen T, Tsatsakis A, Tsegay G, Tsermpini E, Tumurkhuu M, Tung K, Ubah C, Udoakang A, Udoh A, Ullah A, Ullah S, Umair M, Umar T, Unim B, Unnikrishnan B, Upadhyay E, Usman J, Vahabi S, Vaithinathan A, Valizadeh R, Van den Eynde J, Varga O, Varma S, Vart P, Varthya S, Vasankari T, Vellingiri B, Vervoort D, Villafañe J, Violante F, Viskadourou M, Volovat S, Vos T, Vujcic I, Wafa H, Wahab F, Wang C, Wang F, Wang N, Wang S, Wang Y, Wang Y, Wei M, Werdecker A, Wickramasinghe N, Wijeratne T, Wilandika A, Wilson S, Wolfe C, Wongsin U, Wu Z, Xiao H, Xu S, Xu X, Yadav L, Yano Y, Yaribeygi H, Yasufuku Y, Nia I, Ye P, Yesuf S, Yezli S, Yiğit A, Yiğit V, Yilma M, Yon D, Yonemoto N, Yousefi Z, Yperzeele L, Yu C, Yunusa I, Zafari N, Tajrishi F, Zakham F, Zastrozhin M, Zeineddine M, Zemedikun D, Zeng Y, Zhai C, Zhang C, Zhang H, Zhang H, Zhang L, Zhang N, Zhang Y, Zhao H, Zheng P, Zhong C, Zhou S, Zhu B, Zhu L, Zielińska M, Zikarg Y, Zmaili M, Zoeckler L, Zou Z, Zumla A, Zweck E, Zyoud S, Fuster V, Murray C, Roth G. Global Burden of Cardiovascular Diseases and Risks, 1990-2022. Journal Of The American College Of Cardiology 2023, 82: 2350-2473. PMID: 38092509, PMCID: PMC7615984, DOI: 10.1016/j.jacc.2023.11.007.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsThe Potential Role of PET in the Management of Peripheral Artery Disease
Alashi A, Vermillion B, Sinusas A. The Potential Role of PET in the Management of Peripheral Artery Disease. Current Cardiology Reports 2023, 25: 831-839. PMID: 37314651, DOI: 10.1007/s11886-023-01904-8.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseArtery diseaseLower extremitiesManagement of PADSetting of PADEarly detectionLarge vessel diseaseManagement of patientsNon-invasive testsPositron emission tomography (PET) imagingEmission Tomography ImagingNon-invasive toolVascular inflammationVessel diseaseMicrovascular perfusionRoutine screeningBlood flowClinical researchPatientsDiseaseTomography imagingPET imagingSkeletal musclePotential roleSummaryThe purpose
2022
Prognostic value of age-sex adjusted NT-proBNP ratio in obstructive hypertrophic cardiomyopathy
Hutt E, Mentias A, Alashi A, Wadhwa R, Fava A, Lever HM, Thamilarasan M, Popovic ZB, Smedira NG, Desai MY. Prognostic value of age-sex adjusted NT-proBNP ratio in obstructive hypertrophic cardiomyopathy. Progress In Cardiovascular Diseases 2022, 74: 11-18. PMID: 35952727, DOI: 10.1016/j.pcad.2022.08.002.Peer-Reviewed Original ResearchConceptsSeptal reduction therapyBNP ratioNT-proBNP ratioPrimary outcomeAsymptomatic patientsPrognostic valueObstructive hypertrophic cardiomyopathy patientsIncremental prognostic valueNormal NT-proBNPNT-pro BNPObstructive hypertrophic cardiomyopathyLong-term outcomesHypertrophic cardiomyopathy patientsCardiac transplantationNT-proBNPPrimary endpointCardiomyopathy patientsHypertrophic cardiomyopathyReduction therapyHigh riskPatientsDefibrillator dischargeSpline analysisOutcomesBNPThe Enhanced Cardiac Outcome of Conjugated SGLT2 Inhibitors and GLP-1RA Therapy in Diabetic Patients
Fadah K, Alashi A, Deoker A. The Enhanced Cardiac Outcome of Conjugated SGLT2 Inhibitors and GLP-1RA Therapy in Diabetic Patients. Current Cardiology Reports 2022, 24: 17-22. PMID: 35000149, DOI: 10.1007/s11886-021-01619-8.Peer-Reviewed Original ResearchConceptsDiabetic populationDiabetic patientsSGLT2 inhibitorsGlucagon-like peptide-1 receptor agonistsSodium-glucose cotransporter 2 inhibitorsMajor adverse cardiovascular eventsReal-world cohort studyPeptide-1 receptor agonistsAdditional cardiovascular benefitsGLP-1RA therapyAdverse cardiovascular eventsCotransporter 2 inhibitorsMechanism of actionGLP-1RAsAntihyperglycemic therapyCardiac complicationsCardiac mortalityCardiovascular eventsCardiac outcomesCardiovascular benefitsCohort studyDrug therapyReceptor agonistCardioprotective processesReviewCardiovascular disease
2021
Outcomes in Patients With Obstructive Hypertrophic Cardiomyopathy and Concomitant Aortic Stenosis Undergoing Surgical Myectomy and Aortic Valve Replacement
Desai MY, Alashi A, Popovic ZB, Wierup P, Griffin BP, Thamilarasan M, Johnston D, Svensson LG, Lever HM, Smedira NG. Outcomes in Patients With Obstructive Hypertrophic Cardiomyopathy and Concomitant Aortic Stenosis Undergoing Surgical Myectomy and Aortic Valve Replacement. Journal Of The American Heart Association 2021, 10: e018435. PMID: 34533040, PMCID: PMC8649531, DOI: 10.1161/jaha.120.018435.Peer-Reviewed Original ResearchConceptsObstructive hypertrophic cardiomyopathySevere aortic stenosisAortic valve replacementVentricular outflow tract gradientOutflow tract gradientAortic stenosisHypertrophic cardiomyopathySurgical myectomyValve replacementTract gradientRisk factorsAV areaDynamic left ventricular outflow tract gradientDynamic left ventricular outflow tract obstructionLeft ventricular outflow tract gradientLeft ventricular outflow tract obstructionUS populationRight ventricular systolic pressureSevere obstructive hypertrophic cardiomyopathySudden death risk factorsVentricular outflow tract obstructionMultivariate Cox survival analysisLeft ventricular outflow tractBackground Hypertrophic cardiomyopathyBasal septal thicknessDepressed right ventricular systolic function in heart failure due to constrictive pericarditis
Raizada V, Sato K, Alashi A, Kumar A, Kwon D, Ramchand J, Dillenbeck A, Zumwalt RE, Vangala AS, Earley TD, Klein A. Depressed right ventricular systolic function in heart failure due to constrictive pericarditis. ESC Heart Failure 2021, 8: 3119-3129. PMID: 34137193, PMCID: PMC8318427, DOI: 10.1002/ehf2.13418.Peer-Reviewed Original ResearchConceptsClinical heart failureConstrictive pericarditisHeart failureRight ventricularMyocardial infiltrationDiastolic fillingSystolic functionPericardial diseaseRight ventricular systolic functionBiventricular systolic functionPulmonary artery pressureVentricular systolic functionStudy of patientsProgression of fibrosisBiventricular myocardiumArtery pressureCardiac histopathologyCardiac catheterizationRV myocardiumAutopsied heartsHistopathologic examinationPericardial thicknessEcho indicesVentricular myocardiumHealthy adultsCharacteristics and Outcomes of Elderly Patients With Hypertrophic Cardiomyopathy
Alashi A, Smedira NG, Popovic ZB, Fava A, Thamilarasan M, Kapadia SR, Wierup P, Lever HM, Desai MY. Characteristics and Outcomes of Elderly Patients With Hypertrophic Cardiomyopathy. Journal Of The American Heart Association 2021, 10: e018527. PMID: 33506683, PMCID: PMC7955450, DOI: 10.1161/jaha.120.018527.Peer-Reviewed Original ResearchConceptsLeft ventricular outflow tract gradientVentricular outflow tract gradientOutflow tract gradientElderly patientsHypertrophic cardiomyopathyTract gradientObstructive subgroupRisk factorsDynamic left ventricular outflow tract obstructionSudden cardiac death risk factorsLeft ventricular outflow tract obstructionAppropriate internal defibrillator dischargeVentricular outflow tract obstructionBasal septal thicknessConclusion Elderly patientsDeath risk factorsSeptal reduction therapyThoracic Surgeons scoreConsecutive elderly patientsOutflow tract obstructionVentricular mass indexBasal septal hypertrophyLong-term outcomesHospital deathTract obstruction
2020
Outcomes in Guideline‐Based Class I Indication Versus Earlier Referral for Surgical Myectomy in Hypertrophic Obstructive Cardiomyopathy
Alashi A, Smedira NG, Hodges K, Popovic ZB, Thamilarasan M, Wierup P, Lever HM, Desai MY. Outcomes in Guideline‐Based Class I Indication Versus Earlier Referral for Surgical Myectomy in Hypertrophic Obstructive Cardiomyopathy. Journal Of The American Heart Association 2020, 10: e016210. PMID: 33342243, PMCID: PMC7955478, DOI: 10.1161/jaha.120.016210.Peer-Reviewed Original ResearchMeSH KeywordsCardiac Surgical ProceduresCardiomyopathy, HypertrophicDissectionEarly Medical InterventionEchocardiography, StressExercise TestFemaleHumansMaleMiddle AgedOutcome and Process Assessment, Health CarePatient SelectionPractice Guidelines as TopicSeverity of Illness IndexSurvival AnalysisUnited StatesConceptsVentricular outflow tract gradientObstructive coronary artery diseaseBetter long-term survivalSurgical myectomyOutflow tract gradientObstructive hypertrophic cardiomyopathyCoronary artery diseaseLong-term survivalClass ITract gradientEarly surgeryArtery diseaseHypertrophic cardiomyopathyLeft ventricular outflow tract gradientAppropriate internal defibrillator dischargePrimary composite end pointBasal septal thicknessClass I indicationsPrimary composite eventsHypertrophic obstructive cardiomyopathyComposite end pointLong-term outcomesComposite eventsEarly referralObstructive cardiomyopathyImpact of Temporal Changes in Left Ventricular Systolic Function on Outcomes in Takotsubo Cardiomyopathy
Isaza N, Alashi A, Faulx J, Popovic ZB, Menon V, Ellis SG, Faulx M, Kapadia SR, Griffin BP, Desai MY. Impact of Temporal Changes in Left Ventricular Systolic Function on Outcomes in Takotsubo Cardiomyopathy. JACC Cardiovascular Imaging 2020, 14: 1273-1274. PMID: 33341418, DOI: 10.1016/j.jcmg.2020.10.021.Peer-Reviewed Original ResearchCharacteristics and Longer-Term Outcomes of Contemporary Patients <18 Years of Age With Hypertrophic Cardiomyopathy
Alashi A, Svensson L, Klein J, Zahka K, Smedira NG, Najm H, Lever HM, Aziz P, Desai MY. Characteristics and Longer-Term Outcomes of Contemporary Patients <18 Years of Age With Hypertrophic Cardiomyopathy. The American Journal Of Cardiology 2020, 140: 110-117. PMID: 33159906, DOI: 10.1016/j.amjcard.2020.10.060.Peer-Reviewed Original ResearchConceptsOrthotopic heart transplantPrimary composite eventsSudden cardiac deathPresence of symptomsZ-scoreFractional shorteningAppropriate internal defibrillator dischargeVentricular outflow tract gradientLeft ventricular wall thicknessLV septal thicknessOutflow tract gradientPrimary composite outcomeAppropriate ICD dischargeComposite primary endpointLV fractional shorteningVentricular wall thicknessHypertrophic cardiomyopathy patientsYears of ageComposite eventsTract gradientHospital deathPrimary endpointComposite outcomeExperienced centersPHC patientsLong-Term Outcomes of Patients With Mediastinal Radiation–Associated Coronary Artery Disease Undergoing Coronary Revascularization With Percutaneous Coronary Intervention and Coronary Artery Bypass Grafting
Dunn AN, Donnellan E, Johnston DR, Alashi A, Reed GW, Jellis C, Krishnaswamy A, Gillinov AM, Svensson LG, Ellis S, Griffin BP, Kapadia SR, Pettersson GB, Desai MY. Long-Term Outcomes of Patients With Mediastinal Radiation–Associated Coronary Artery Disease Undergoing Coronary Revascularization With Percutaneous Coronary Intervention and Coronary Artery Bypass Grafting. Circulation 2020, 142: 1399-1401. PMID: 33017210, DOI: 10.1161/circulationaha.120.046575.Peer-Reviewed Original ResearchCharacteristics and Outcomes of Patients With Takotsubo Syndrome: Incremental Prognostic Value of Baseline Left Ventricular Systolic Function
Alashi A, Isaza N, Faulx J, Popovic ZB, Menon V, Ellis SG, Faulx M, Kapadia SR, Griffin BP, Desai MY. Characteristics and Outcomes of Patients With Takotsubo Syndrome: Incremental Prognostic Value of Baseline Left Ventricular Systolic Function. Journal Of The American Heart Association 2020, 9: e016537. PMID: 32755253, PMCID: PMC7660826, DOI: 10.1161/jaha.120.016537.Peer-Reviewed Original ResearchConceptsBaseline LV ejection fractionLV ejection fractionIncremental prognostic valueLV-GLSTakotsubo syndromePrognostic valueLower baseline LV ejection fractionObstructive coronary artery diseaseVentricular global longitudinal strainMultivariate Cox survival analysisMean LV ejection fractionWorse LV-GLSOutcomes of patientsPrimary end pointVentricular systolic functionCoronary artery diseaseGlobal longitudinal strainLong-term outcomesCox survival analysisPhysical triggersPrognostic cutoffCause mortalityApical ballooningConclusions PatientsSystolic functionLV Global Function Index Provides Incremental Prognostic Value Over LGE and LV GLS in HCM
Desai MY, Mentias A, Alashi A, Flamm SD, Thamilarasan M, Lever HM, Popovic ZB. LV Global Function Index Provides Incremental Prognostic Value Over LGE and LV GLS in HCM. JACC Cardiovascular Imaging 2020, 13: 2052-2054. PMID: 32563635, DOI: 10.1016/j.jcmg.2020.03.023.Peer-Reviewed Original ResearchExaggerated blood pressure response on exercise treadmill testing and longer term outcomes in primary prevention
Riaz H, Alashi A, Lang R, Seballos R, Feinleib S, Sukol R, Cho L, Cremer P, Jaber W, Griffin BP, Desai MY. Exaggerated blood pressure response on exercise treadmill testing and longer term outcomes in primary prevention. European Heart Journal - Quality Of Care And Clinical Outcomes 2020, 6: 343-344. PMID: 32514546, DOI: 10.1093/ehjqcco/qcaa043.Peer-Reviewed Original ResearchGlobal, Regional, and National Burden of Calcific Aortic Valve and Degenerative Mitral Valve Diseases, 1990-2017
Yadgir S, Johnson CO, Aboyans V, Adebayo OM, Adedoyin RA, Afarideh M, Alahdab F, Alashi A, Alipour V, Arabloo J, Azari S, Barthelemy CM, Benziger CP, Berman AE, Bijani A, Carrero JJ, Carvalho F, Daryani A, Durães AR, Esteghamati A, Farid TA, Farzadfar F, Fernandes E, Filip I, Gad MM, Hamidi S, Hay SI, Ilesanmi OS, Irvani S, Jürisson M, Kasaeian A, Kengne AP, Khan AR, Kisa A, Kisa S, Kolte D, Manafi N, Manafi A, Mensah GA, Mirrakhimov EM, Mohammad Y, Mokdad AH, Negoi RI, Nguyen H, Nguyen TH, Nixon MR, Otto CM, Patel S, Pilgrim T, Radfar A, Rawaf DL, Rawaf S, Rawasia WF, Rezapour A, Roever L, Saad AM, Saadatagah S, Senthilkumaran S, Sliwa K, Tesfay BE, Tran BX, Ullah I, Vaduganathan M, Vasankari TJ, Wolfe CDA, Yonemoto N, Roth GA. Global, Regional, and National Burden of Calcific Aortic Valve and Degenerative Mitral Valve Diseases, 1990-2017. Circulation 2020, 141: 1670-1680. PMID: 32223336, DOI: 10.1161/circulationaha.119.043391.Peer-Reviewed Original ResearchMeSH KeywordsAge DistributionAortic ValveAortic Valve InsufficiencyAortic Valve StenosisCalcinosisCost of IllnessFemaleGlobal HealthHealth Status DisparitiesHealthcare DisparitiesHumansMaleMitral Valve InsufficiencyMitral Valve ProlapsePrevalenceQuality of LifeRisk AssessmentRisk FactorsTime FactorsConceptsCalcific aortic valve diseaseDegenerative mitral valve diseaseMitral valve diseaseValve diseaseValvular diseaseNational burdenDisease burdenGlobal burdenAge-standardized DALY ratesHigher age-standardized DALY ratesModifiable risk factorsAortic valve diseaseCalcific aortic valvesDisease Study 2017Number of DALYsAdministrative hospital dataHealth-related burdenEpidemiologic survey dataDALY ratesValve repairTreatable diseaseAortic valveRisk factorsOverall burdenPrevalent cases
2019
Outcomes of Patients With Mediastinal Radiation-Associated Mitral Valve Disease Undergoing Cardiac Surgery
Donnellan E, Alashi A, Johnston DR, Gillinov AM, Pettersson GB, Svensson LG, Griffin BP, Desai MY. Outcomes of Patients With Mediastinal Radiation-Associated Mitral Valve Disease Undergoing Cardiac Surgery. Circulation 2019, 140: 1288-1290. PMID: 31589484, DOI: 10.1161/circulationaha.119.040546.Peer-Reviewed Original ResearchA novel machine learning-derived radiotranscriptomic signature of perivascular fat improves cardiac risk prediction using coronary CT angiography
Oikonomou EK, Williams MC, Kotanidis CP, Desai MY, Marwan M, Antonopoulos AS, Thomas KE, Thomas S, Akoumianakis I, Fan LM, Kesavan S, Herdman L, Alashi A, Centeno EH, Lyasheva M, Griffin BP, Flamm SD, Shirodaria C, Sabharwal N, Kelion A, Dweck MR, Van Beek EJR, Deanfield J, Hopewell JC, Neubauer S, Channon KM, Achenbach S, Newby DE, Antoniades C. A novel machine learning-derived radiotranscriptomic signature of perivascular fat improves cardiac risk prediction using coronary CT angiography. European Heart Journal 2019, 40: 3529-3543. PMID: 31504423, PMCID: PMC6855141, DOI: 10.1093/eurheartj/ehz592.Peer-Reviewed Original ResearchConceptsPerivascular adipose tissueFat attenuation indexCoronary CT angiographyCardiac risk predictionCoronary perivascular adipose tissueMajor adverse cardiac eventsCT angiographyRisk predictionHigh-risk plaque featuresPerivascular fat attenuation indexRadiomic featuresAdverse cardiac eventsConsecutive eligible participantsSCOT-HEART trialTraditional risk stratificationCoronary artery diseaseCoronary calcium scoreStandard coronary CT angiographyAcute myocardial infarctionCoronary inflammationCardiac eventsArtery diseaseCalcium scoreCardiac surgeryMACE predictionDifferent Histopathologic Diagnoses in Patients With Clinically Diagnosed Hypertrophic Cardiomyopathy After Surgical Myectomy
Alashi A, Desai RM, Khullar T, Hodges K, Rodriguez ER, Tan C, Popovic ZB, Thamilarasan M, Wierup P, Lever HM, Smedira NG, Desai MY. Different Histopathologic Diagnoses in Patients With Clinically Diagnosed Hypertrophic Cardiomyopathy After Surgical Myectomy. Circulation 2019, 140: 344-346. PMID: 31329486, DOI: 10.1161/circulationaha.119.040129.Peer-Reviewed Original ResearchCharacteristics and Outcomes in a Contemporary Group of Patients With Suspected Significant Mitral Stenosis Undergoing Treadmill Stress Echocardiography
Gentry JL, Parikh PK, Alashi A, Gillinov AM, Pettersson GB, Rodriguez LL, Popovic ZB, Sato K, Grimm RA, Kapadia SR, Tuzcu EM, Svensson LG, Griffin BP, Desai MY. Characteristics and Outcomes in a Contemporary Group of Patients With Suspected Significant Mitral Stenosis Undergoing Treadmill Stress Echocardiography. Circulation Cardiovascular Imaging 2019, 12: e009062. PMID: 31203672, DOI: 10.1161/circimaging.119.009062.Peer-Reviewed Original ResearchConceptsRight ventricular systolic pressureTreadmill stress echocardiographyVentricular systolic pressureStress echocardiographySystolic pressureMetabolic equivalentsMV gradientMitral proceduresHigh mortalityThoracic Surgeons scoreLong-term survivalAsymptomatic patientsCause mortalityPrimary outcomeSurgeons scoreConsecutive patientsImproved survivalContemporary patientsMV proceduresPatientsEchocardiographySignificant MSSurvival analysisModerate MSMortalityIncremental Prognostic Value of Exercise Stress Testing in Primary Prevention
Alashi A, Riaz H, Lang R, Seballos R, Feinleib S, Sukol R, Cho L, Cremer P, Jaber W, Griffin BP, Desai MY. Incremental Prognostic Value of Exercise Stress Testing in Primary Prevention. The American Journal Of Cardiology 2019, 124: 216-223. PMID: 31104779, DOI: 10.1016/j.amjcard.2019.04.021.Peer-Reviewed Original ResearchConceptsHeart rate recoveryIncremental prognostic valueC-reactive proteinPrimary preventionPrognostic valueLong-term eventsCV diseaseDerivation groupFamily historyValidation groupStandard risk factor assessmentProspective observational cohort studyContinuous net reclassification improvementConsecutive asymptomatic adultsPremature CV diseaseSuperior risk stratificationTreadmill stress testingFuture cardiovascular eventsObservational cohort studyExercise stress testingMultivariable survival analysisRisk factor assessmentNet reclassification improvementBeats/minStress testing